Sialic acid levels in serum and tissue from colorectal cancer patients

Feijoo, C.; Cadena, Marı́a Páez de la; Rodrı́guez-Berrocal, Francisco Javier; Martínez-Zorzano, Vicenta S.

doi:10.1016/s0304-3835(96)04564-8

Cited by 33 publications

(31 citation statements)

References 17 publications

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“…We found that breast cancer patients had significantly higher levels of different ~rms of sialic acid as compared to the controls. The results on serum sialic acid levels in present study were in accordance with the reports from our laboratory as well as of other workers (6,30,31). Previous reports on sialic acid in cancer have mostly compared the levels with healthy individuals.…”

Section: Discussionsupporting

confidence: 94%

“…Therefore, the patients with BBD served as pathological controls in the current study. Current study also revealed that serum sialic acid have significant positive correlation with stage of the malignant disease which is in accordance with previous reports (6,30,32).…”

Section: Discussionsupporting

confidence: 92%

“…The study revealed significantly higher concentrations of sialic acid in tissue homogenates of malignant tumours as compared to that of surrounding normal tissues. Significantly higher levels of sialic acid in tumour tissue have also been reported by various-workers (6,46). Similar observations for abnormal levels of glycoprotein constituents have been documented in tissue extracts of liver cancer (34,47).…”

Section: -71supporting

confidence: 77%

“…Altered glycosylation of glycoconjugates is one of the important molecular changes that accompany malignant transformation (5,3). Sialic acid, the end moieties of the carbohydrate chain of glycoconjugates are reported to be elevated during malignancy (6,7). Increased levels of sialic acid in cancer patients can be explained by spontaneous release (shedding) of aberrant sialic acid rich glycoproteins and glycolipids (8,9,4).…”

Section: Indian Journal Of C/inical Biochemistry 2004mentioning

confidence: 99%

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Clinical usefulness of alterations in sialic acid, sialyl transferase and sialoproteins in breast cancer

Raval

Parekh

Patel

et al. 2004

Indian J Clin Biochem

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Sialic acid, the end moieties of the carbohydrate chains are biologically important and essential for functions of glycoconjugates and are reported to be altered in cancer patients. Two hundred and twenty five breast cancer (BC) patients, 100 patients with benign breast disease (BBD) and 100 healthy females (controls) were enrolled for the study. Eight hundred and twenty four f011ow-up samples of 225 breast carcinoma patients were also evaluated. The association of static acid forms, sialyltransferase and ~-2-6 sialoproteins levels with presence and extent as well as prognosis of breast carcinoma was studie~. Serum sialic acid forms and sialyltransferase revealed significantly elevated levels among untreated breast cancer patients as compared to the controls, patients with BBD as well as cancer patients in remission. Non-responders showed comparable levels of the markers with those found in breast cancer patients at the time of diagnosis. Higher levels of sialic acid forms at diagnosis were associated with poor prognosis. A positive correlation between serum levels of different forms of sialic acids and extent of malignant disease was observed. The changes in serum proteins with terminal a-2-6 sialic acid correlated well with alterations in the levels of sialic acid forms and sialyltransferase. Malignant tissues showed elevated levels of sialic acid and sialyltransferase as compared to surrounding normal tissues.The results suggested potential utility of these markers in evaluation of clinical outcome.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 92%

Section: -71supporting

confidence: 77%

Section: Indian Journal Of C/inical Biochemistry 2004mentioning

confidence: 99%

See 2 more Smart Citations

Clinical usefulness of alterations in sialic acid, sialyl transferase and sialoproteins in breast cancer

Raval

Parekh

Patel

et al. 2004

Indian J Clin Biochem

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“…A number of studies demonstrated the feasibility of determining sialic acids for the diagnosis of colorectal cancer [7], thyroid cancer [8], prostate cancer [9], ovary cancer [10], and oral cavity cancer [11]. However, the diagnostic value of sialic acids as a marker of LC was never explored.…”

Section: Introductionmentioning

confidence: 99%

Sialic Acids of Saliva in Primary and Differential Diagnosis of Lung Cancer

Bel’skaya¹,

Kosenok²,

Массард³

2018

Sovrem Tehnol Med

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The aim of the study was to explore the option of using sialic acid of saliva as a marker for primary and differential diagnosis of lung cancer.Materials and Methods. The study included 1903 subjects divided as follows: the main group (lung cancer, n=337, and nonmalignant lung diseases, n=108), the comparison group (other types of oncological diseases, n=1033), and the control group (generally healthy, n=425). All participants filled the medical questionnaires and presented the histological verification of their diagnoses; then they underwent biochemical examination of their saliva samples. The level of sialic acids and the content of mucin in the saliva were determined spectrophotometrically.Results. We found that the average level of sialic acids in the control group (0.270±0.037 mmol/L) was significantly higher than that in lung cancer (0.138±0.006 mmol/L) or non-tumor diseases of the lungs (0.148±0.003 mmol/L). The saliva content of sialic acids did not significantly differ between various histological types of lung cancer (0.175±0.027 and 0.166±0.024 mmol/L for squamous cell lung cancer and adenocarcinoma, respectively). We also noted that in patients with metastatic lung cancer, the level of sialic acids in the saliva was the lowest as compared with the generally healthy subjects.Conclusion. The level of sialic acids in the saliva decreases both in patients with lung cancer and in patients with non-malignant lung diseases. These results rationalize the option of using this parameter for the primary diagnosis of lung disorders as a whole; however, for the differential diagnosis of various lung diseases, the level of saliva sialic acids is of little value.

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Evaluation of glycoprotein constituents in head and neck cancer patients undergoing radiotherapy

Rawal

Patel

et al. 1999

Head Neck

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Sialic acid levels in serum and tissue from colorectal cancer patients

Cited by 33 publications

References 17 publications

Clinical usefulness of alterations in sialic acid, sialyl transferase and sialoproteins in breast cancer

Clinical usefulness of alterations in sialic acid, sialyl transferase and sialoproteins in breast cancer

Sialic Acids of Saliva in Primary and Differential Diagnosis of Lung Cancer

Evaluation of glycoprotein constituents in head and neck cancer patients undergoing radiotherapy

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