Sialic acid receptors: focus on their role in influenza infection

Ayora-Talavera, Guadalupe

doi:10.2147/jrlcr.s140624

Cited by 21 publications

(19 citation statements)

References 91 publications

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“…Circulating avian H9N2 viruses were reported to be the origin of the H7N4 internal segments, unlike both the human H5N1 and H7N9 viruses that had H9N2 backbones. The major concern is that genetic reassortment and adaptive mutation of avian influenza virus give rise to human influenza virus strain H7N4 ( Jiao et al, 2012 ; Ayora-Talavera, 2018 ; Karen, 2018 ; Li et al, 2020 ). The WHO has also warned about the pandemic on human flu resulting from genetic reassortment of avian influenza ( Qu et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

“…It is gradually evolving from the low pathogenic form to the high pathogenic form and observed to overcome species barrier with interspecies genetic assortment ( Kumar et al, 2018 ; Richard et al, 2002b ; Gillim-Ross et al, 2008 ; FAO, 2019 ) and every possibility to evolve as a pandemic for human. Reports are available depicting human influenza virus arising due to genetic reassortment of avian influenza in China ( Jiao et al, 2012 ; Ayora-Talavera, 2018 ; Karen, 2018 ; Li et al, 2020 ). These findings highlight the growing importance of the study in the current era, when the world is suffering from a pandemic.…”

Section: Discussionmentioning

confidence: 99%

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RIGI, TLR7, and TLR3 Genes Were Predicted to Have Immune Response Against Avian Influenza in Indigenous Ducks

Pal

Baviskar

2021

Front. Mol. Biosci.

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Avian influenza is a disease with every possibility to evolve as a human-to-human pandemic arising out of frequent mutations and genetic reassortment or recombination of avian influenza (AI) virus. The greatest concern is that till date, no satisfactory medicine or vaccines are available, leading to massive culling of poultry birds, causing huge economic loss and ban on export of chicken products, which emphasizes the need to develop an alternative strategy for control of AI. In the current study, we attempt to explore the molecular mechanism of innate immune potential of ducks against avian influenza. In the present study, we have characterized immune response molecules such as duck TLR3, TLR7, and RIGI that are predicted to have potent antiviral activities against the identified strain of avian influenza through in silico studies (molecular docking) followed by experimental validation with differential mRNA expression analysis. Future exploitation may include immunomodulation with the recombinant protein, and transgenic or gene-edited chicken resistant to bird flu.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

RIGI, TLR7, and TLR3 Genes Were Predicted to Have Immune Response Against Avian Influenza in Indigenous Ducks

Pal

Baviskar

2021

Front. Mol. Biosci.

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“…The importance of sialic acid residues as a target for attachment of Influenza is well known [36,37]. However, human coronaviruses OC43 and HKU1 also bind to 9- O -acetylated sialic acids via a conserved receptor-binding site in spike protein domain A [38].…”

Section: Discussionmentioning

confidence: 99%

Direct detection of humoral marker corelates of COVID-19, glycated HSA and hyperglycosylated IgG3, by MALDI-ToF mass spectrometry

Iles

Zmuidinaite

et al. 2021

Preprint

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The prefusion Spike protein of SARS-CoV2 binds advanced glycation end product (AGE) glycated human serum albumin (HSA) and a higher mass, hyperglycosylated/glycated, IgG3, as determined by matrix assisted laser desorption mass spectrometry (MALDI-ToF MS). We set out to investigate if the total blood plasma of patients who had recovered from acute respiratory distress as a result of COVID-19, contained more glycated HSA and higher mass (glycosylated/glycated) IgG3 than those with only clinically mild or asymptomatic infections. A direct dilution and disulphide bond reduction method was development and applied to plasma samples from SARS-CoV2 seronegative (N = 30) and seropositive (N = 31) healthcare workers and 38 convalescent plasma samples from patients who had been admitted with acute respiratory distress syndrome (ARDS) associated with COVID-19.Patients recovering from COVID-19 ARDS had significantly higher mass, AGE-glycated HSA and higher mass IgG3 levels. This would indicate that increased levels and/or ratios of hyper-glycosylation (probably terminal sialic acid) IgG3 and AGE glycated HSA may be predisposition markers for development of ARDS as a result of COVID-19 infection. Furthermore, rapid direct analysis of plasma samples by MALDI-ToF MS for such humoral immune correlates of COVID-19 presents a feasible screening technology for the most at risk; regardless of age or known health conditions.Abstract Figure

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“…During the first step of IAV infection of the host cell, attachment, HA binds to the target cell via sialic acid linkages on host glycoproteins [ 68 , 69 ]. The sialic acid binding specificity of HA is one of the major determinants for viral tropism and host specificity; changes in key HA amino acids that control its binding specificity have been identified to contribute to the spillover of avian viruses to humans, leading to new influenza epidemics [ 70 , 71 , 72 , 73 ].…”

Section: The Infection Cycle Of Iavmentioning

confidence: 99%

How Influenza Virus Uses Host Cell Pathways during Uncoating

Moreira

Yamauchi

Matthias

2021

Cells

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Influenza is a zoonotic respiratory disease of major public health interest due to its pandemic potential, and a threat to animals and the human population. The influenza A virus genome consists of eight single-stranded RNA segments sequestered within a protein capsid and a lipid bilayer envelope. During host cell entry, cellular cues contribute to viral conformational changes that promote critical events such as fusion with late endosomes, capsid uncoating and viral genome release into the cytosol. In this focused review, we concisely describe the virus infection cycle and highlight the recent findings of host cell pathways and cytosolic proteins that assist influenza uncoating during host cell entry.

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Sialic acid receptors: focus on their role in influenza infection

Cited by 21 publications

References 91 publications

RIGI, TLR7, and TLR3 Genes Were Predicted to Have Immune Response Against Avian Influenza in Indigenous Ducks

RIGI, TLR7, and TLR3 Genes Were Predicted to Have Immune Response Against Avian Influenza in Indigenous Ducks

Direct detection of humoral marker corelates of COVID-19, glycated HSA and hyperglycosylated IgG3, by MALDI-ToF mass spectrometry

How Influenza Virus Uses Host Cell Pathways during Uncoating

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