Sialoadenectomy enhances hepatic injury induced by lipopolysaccharide/galactosamine in mice

Sánchez, Olga; Almagro, Albert; Viladrich, M. C.; Ramı́rez, Ignasi; Soley, Maria

doi:10.1111/j.1478-3231.2008.01713.x

Cited by 4 publications

(5 citation statements)

References 44 publications

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“…Differential expression of keratins of tongue coating might be closely related to the changes in functional substances caused by hepatitis B disease. Epidermal growth factor (EGF) in saliva was overexpressed,42, 43 while liver injury which might be caused by hepatitis B disease 24. The increased level of EGF might be associated with the differential expression of keratins in tongue coating.…”

Section: Resultsmentioning

confidence: 99%

Studies of keratins in tongue coating samples of hepatitis B patients by mass spectrometry

Fang

Liu

Wang

et al. 2009

Rapid Comm Mass Spectrometry

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Pooled tongue coating samples from 64 hepatitis B patients and 24 healthy adults were studied and a major band of differential proteins was found by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). The differential proteins in this band were identified and proved to be keratins by liquid chromatography/tandem mass spectrometry (LC/MS/MS) and Western blot analysis. Furthermore, relative quantification of the identified keratins was performed via using stable isotopic labeling and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), showing the higher expression level of these keratins in tongue coating samples of hepatitis B patients than healthy adults. These results provided additional information to understand the medical diagnosis depending on the tongue coating.

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Section: Resultsmentioning

confidence: 99%

Studies of keratins in tongue coating samples of hepatitis B patients by mass spectrometry

Fang

Liu

Wang

et al. 2009

Rapid Comm Mass Spectrometry

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“…We have previously reported that sialoadenectomy induces mild liver injury in young mice [5,56] and that this results in increased sensitivity to the hepatotoxic effect of bacterial lipopolysaccharides [49]. Several stressors also induce mild liver injury in young adult mice [13,48], and it is known that stress exacerbates the damaging effect of several toxins [7,41,43].…”

Section: Consequences On Life Spanmentioning

confidence: 98%

“…This leads to a reduction in the number of remaining hepatocytes, accompanied by an increase in their size [5]. These alterations render the liver more sensitive to bacterial toxins [49].…”

Section: Introductionmentioning

confidence: 99%

Submandibular salivary glands: influence on growth rate and life span in mice

Ramı́rez

Soley

2010

J Physiol Biochem

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Submandibular glands accumulate a variety of growth factors, especially in male mice. Surgical excision of these glands (sialoadenectomy) results in alterations in several organs and systems including the liver, skin and reproductive system. We studied the life-long consequences of sialoadenectomy in male mice. Animals were operated at the age of 10 weeks. Thereafter, body weight and food and water intake were controlled until death. Few weeks after surgery, body weight was lower in sialoadenectomized than in control mice. The difference remained stable until the age of 80 weeks. In spite of the lower body weight, food intake was higher in sialoadenectomized mice than in controls. The first death of sialoadenectomized mice occurred 10 weeks earlier than that of the first control, and the initial death rate in sialoadenectomized mice was almost twice the rate in controls. After 100 weeks of life, the death rate increased in control mice, but suddenly decreased in sialoadenectomized mice. The consequence was that the mean life span of the last 25% surviving animals was 10 weeks longer in sialoadenectomized than in control mice. Autopsy examination suggests that the effect of sialoadenectomy on death rate may be the consequence of a contrasting effect on tumour growth. Our results indicate that submandibular glands, or rather the factors derived from these glands, have contrasting roles in tumour growth. At early ages they may be survival factors and protect tissues, whereas at later ages they may stimulate the growth of transformed cells.

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“…Host hormones also play important roles in liver diseases (110–113). Females are generally considered to be more susceptible to alcohol‐induced liver injury than males.…”

Section: Crosstalk With Other Physiological and Pathophysiological Mementioning

confidence: 99%

Acute liver failure: mechanisms of immune-mediated liver injury

Han

Chen

et al. 2010

Liver International

234

164

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Acute liver failure (ALF) is a syndrome of diverse aetiology, including hepatic encephalopathy, renal, cardiac and pulmonary failures, which result in a rapid loss of hepatic function. The mechanisms of liver injury contributing to ALF can be summarized into two categories: direct damage and immune-mediated liver injury. This review summarizes current concepts of immune-mediated liver injury from both clinical studies and animal models. We highlight immune responses of ALF from the liver injury perspective, which combines a variety of molecular and cellular mechanisms, particularly, the contribution of cytokines and the innate immune system. Hepatic and circulating inflammatory cytokines play a significant role in the pathophysiology of ALF including hepatocyte necrosis, extrahepatic complications and hepatocyte regeneration. Overproduction of cytokines, if unchecked, is hazardous to the host and may cause severe outcomes. Measuring pro-inflammatory cytokines in ALF may be of value for predictors of outcome. Innate and adaptive immune systems both involved in ALF contribute to immune-mediated liver injury. The innate immune response is activated much more rapidly compared with adaptive immunity, particularly in acute liver injury where the host has little time to trigger an effective adaptive immune response. From this point of view, the innate immune system may make a more profound contribution than the adaptive immune system. Furthermore, immune responses crosstalk with other physiological or pathophysiological factors, for example, coagulation factors which in turn determine the outcome of ALF and these are discussed.Acute liver failure (ALF) is a syndrome of diverse aetiologies in which patients without liver disease recognized previously sustain a liver injury that results in a rapid loss of hepatic function. The period between the initial symptoms and the manifestations of hepatic encephalopathy is crucial for the prognosis of these patients. Therefore, several groups have included the time window between the appearance of symptoms and the onset of encephalopathy in their definitions. The most recent definition uses the term ALF as hyperacute, acute and subacute liver failure; fulminant or sub-fulminant liver failure. APASL consensus and Chinese consensus suggest that liver failure can develop as ALF (in the absence of any pre-existing liver disease), acuteon-chronic liver failure (ACLF) (an acute deterioration of known or unknown chronic liver disease) or a chronic decompensation of an end-stage liver disease (1, 2).The aetiology of ALF is the most important determinant of outcomes. Differences in aetiology, outcomes and management are well understood. In the East and the developing world, ALF is mainly because of viral infections, primarily hepatitis B, but also A and especially in developing countries, E, as well as other non-hepatotropic viruses. In principle, four different mechanisms are primarily responsible: infectious (mainly viral), drugs/ toxins/chemicals, cardiovascular and metabolic (3...

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Sialoadenectomy enhances hepatic injury induced by lipopolysaccharide/galactosamine in mice

Abstract: Our results suggest that the effect of sialoadenectomy on LPS/GalN-induced liver toxicity may be the consequence of an altered cytokine production by the liver and a reduced CS release from adrenal glands.

Cited by 4 publications

References 44 publications

Studies of keratins in tongue coating samples of hepatitis B patients by mass spectrometry

Studies of keratins in tongue coating samples of hepatitis B patients by mass spectrometry

Submandibular salivary glands: influence on growth rate and life span in mice

Acute liver failure: mechanisms of immune-mediated liver injury

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