Sialoblastoma in the parotid gland: A case report

Ersöz, Şafak; Turgutalp, Havvanur; Çobanoğlu, Ümi̇t; Bektaş, Devrim; Yarış, Nilgün

doi:10.1111/j.1442-200x.2010.03108.x

Cited by 8 publications

(9 citation statements)

References 10 publications

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“…The immunohistochemical results in our case were compatible with previous reports. In addition, our case was also immunohistologically and serologically positive for AFP ( 11 , 13 ). Moreover, immunohistochemical investigation demonstrated positivity for Hep Par-1 in a considerable number of tumor cells.…”

Section: Discussionsupporting

confidence: 55%

“…Microscopically, sialoblastomas exhibit the primitive embryonic histological characteristics of salivary gland tissue, together with basaloid epithelial components and a variable amount of stroma ( 1 , 10 ). This tumor consists of variably arranged, tight clusters or clumps of basaloid-like cells in a background of dispersed epithelial and myoepithelial cells, and partially formed ductal and pseudo-ductal spaces separated by thin fibrous bands ( 8 , 11 ). These microscopic characteristics reflect the pre-acinar stage of salivary gland morphogenesis, together with primitive cell masses, forming ducts and pseudo-ductular spaces, without acinar differentiation ( 3 , 11 ).…”

Section: Discussionmentioning

confidence: 99%

“…Immunohistochemical studies have reported that sialoblastoma stains positive for cytokeratin in the ductal cells and for vimentin, smooth muscle actin and S100 in the outer ductal parts ( 5 , 11 ). Solid nests of basaloid cells are focally positive for S100 and vimentin ( 11 ). The immunohistochemical results in our case were compatible with previous reports.…”

Section: Discussionmentioning

confidence: 99%

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Sialoblastoma of the cheek: A case report and review of the literature

Sitthichaiyakul

Somran

Oilmungmool

et al. 2016

Molecular and Clinical Oncology

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Sialoblastoma is a rare salivary gland tumor that recapitulates the primitive salivary gland anlage. The authors herein report a case of sialoblastoma of a minor salivary gland, clinically presenting with progressive enlargement of a mass in the cheek of a 1-year-old female infant. Histopathologically, the mass consisted of tight clusters of basaloid cells and partially formed ductal and pseudo-ductal spaces separated by thin fibrous bands. Immunohistchemical studies demonstrated the presence of cytokeratin AE1/AE3, p63, CD99, α-fetoprotein (AFP) and Hep Par-1 expression in a considerable number of tumor cells. The clinical and pathological characteristics are presented and relevant literature is reviewed. Early complete surgical excision is recommended for the treatment of sialoblastoma. Radiation may be considered in cases with incomplete resection of the tumor. Chemotherapy may play a vital role in extensive, metastatic, or relapsed cases, or in cases with inadequate excision. The follow-up treatment should be frequent and prolonged. To the best of our knowledge, this is the first reported case of sialoblastoma of the cheek with immunoreactivity for AFP and Hep Par-1, which may be associated with the embryonic origin of the tumor. AFP may be a useful marker of tumor response in patient with sialoblastoma.

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Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Sialoblastoma of the cheek: A case report and review of the literature

Sitthichaiyakul

Somran

Oilmungmool

et al. 2016

Molecular and Clinical Oncology

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“…Ersoz et al describe a patient still receiving chemotherapy for pulmonary relapse at the time of the report. 6 Likewise, Prigent et al described a patient with sialoblastoma and pulmonary metastases who was in remission one year following neoadjuvant chemotherapy and resection. 12 A novel approach to tumor recurrence was recently reported by Shan et al In an effort to preserve facial nerve function and avoid a second extensive resection, brachytherapy with a 125I seed implant was utilized, which lead to a complete clinical response after two months.…”

Section: Discussionmentioning

confidence: 99%

“…However, increasing experience, including reports of distant metastasis, has lead to the reclassification of sialoblastomas as malignant. 6,7 Although the mainstay of treatment is surgical resection with adequate margins, 8 there are reported patients who have received alternative treatments such as neoadjuvant chemotherapy, radiation therapy, and even brachytherapy. We have previously reported a young child who presented with a parotid sialoblastoma at the age of 3.5 months.…”

Section: Introductionmentioning

confidence: 99%

Sialoblastoma- long-term follow-up and remission for a rare salivary malignancy

et al. 2011

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Sialoblastoma is a rare salivary neoplasm which presents either congenitally or during early infancy. It was originally considered a benign neoplasm, however a number of reported cases have documented locoregional recurrence and distant metastases. Currently, there is no consensus on the appropriate treatment for this neoplasm. We report on long term follow-up of a patient with metastatic sialoblastoma, and a brief discussion of the possible treatment modalities currently being considered.

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Clinicopathological study and survival outcomes of sialoblastoma: A systematic review

et al. 2023

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Sialoblastoma is a rare malignant salivary gland tumor. The aim of this study was to review the available published data on sialoblastoma in a comprehensive analysis of its clinicopathologic characteristics, treatment, and outcomes. An unrestricted electronic search was performed in the following databases: MEDLINE/PubMed, EMBASE, Scopus, Web of science, and gray literature databases. Eligibility criteria included publications with sufficient clinical, imaging, and histopathological information to confirm the diagnosis of sialoblastoma. Data were evaluated descriptively and analytically. A total of 52 studies met the eligibility criteria. In total, 62 patients were evaluated. There was no gender predilection, with the parotid being the most affected primary site (n = 28; 45.2%). In the log‐rank test, there was a significant increase in disease‐associated survival in patients younger than 1 year of age (82.8% vs. 44.4%; p = 0.003), individuals with lesions in major salivary glands (79.4% vs. 38.5%; p = 0.005), patients without metastases (77.8% vs. 14.3%; p = 0.011), encapsulated lesions (85.7% vs. 0%; p < 0.0001), congenital lesions (83.3% vs. 25.0%; p < 0.0001), and lesions that do not show perineural invasion (89.5% vs. 40%; p = 0.035). Kaplan–Meier curves estimated overall survival and disease‐free survival at 5 years of 95.5% and 68.1%, respectively. In the multivariate Cox regression model, only the presence of metastasis was identified as an independent prognostic factor (hazard ratio [HR] = 9.81; p = 0.010). Although sialoblastoma presents good prognosis, the tumor has a high recurrence rate.

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Sialoblastoma in the parotid gland: A case report

Cited by 8 publications

References 10 publications

Sialoblastoma of the cheek: A case report and review of the literature

Sialoblastoma of the cheek: A case report and review of the literature

Sialoblastoma- long-term follow-up and remission for a rare salivary malignancy

Clinicopathological study and survival outcomes of sialoblastoma: A systematic review

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