Sialolithiasis is associated with nephrolithiasis: a case-control study

Wu, Chuan Chang; Hung, Shih‐Han; Lin, Herng Ching; Lee, Cha Ze; Lee, Hsin Chien; Chung, Shiu-Dong

doi:10.3109/00016489.2015.1129068

Cited by 22 publications

(26 citation statements)

References 11 publications

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“…Smoking and alcohol consumption were the most commonly performed social habits in patients with sialolithiasis. The association of sialolithiasis with smoking has been reported in several previous studies [1,9,10,12,13]. However, we could not find any study evaluating the correlation between alcohol consumption and sialolithiasis.…”

Section: Introductionmentioning

confidence: 55%

Increased risk of sialolithiasis in smokers: A nested case-control study using a national health screening

Jin¹,

Han²,

Choi³

2020

Preprint

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ObjectivesThe purpose of this study was to evaluate the relationships among tobacco smoking, drinking alcohol, obesity and sialolithiasis in a Korean population.MethodsThe Korean National Health Insurance Service-Health Screening Cohort, which includes patients ≥ 40 years old, was assessed from 2002 to 2013. 947 sialolithiasis participants were matched with 3,788 control subjects at a ratio of 1:4 with respect to age group, sex, income group, region of residence, hypertension, diabetes, and dyslipidemia. We analyzed participants’ previous histories of smoking (current or past smokers compared to nonsmokers) and alcohol consumption (≥ 1 time per week compared to < 1 time per week) in the sialolithiasis and control groups. Obesity was measured using body mass index (BMI, kg/m2), which was categorized as < 18.5 (underweight), ≥ 18.5 and < 23 (normal), ≥ 23 and < 25 (overweight), ≥ 25 and < 30 (obese I), and ≥ 30 (obese II). Crude and adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression analyses.ResultsThe rate of smoking was higher in the sialolithiasis group (32.4% [307/947]) than in the control group (29.1% [1,103/3,788], P = 0.047). The adjusted OR of smoking for sialolithiasis was 1.31 (95% CI = 1.08-1.59, P = 0.006). Alcohol consumption and obesity were not statistically significantly related to sialolithiasis.ConclusionThe odds of smoking were increased in sialolithiasis patients compared with the control subjects in ≥ 40 years old population.

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Section: Introductionmentioning

confidence: 55%

Increased risk of sialolithiasis in smokers: A nested case-control study using a national health screening

Jin¹,

Han²,

Choi³

2020

Preprint

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“…These results indicate 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 that a reduced salivary citrate concentration and increased pH could increase calcium deposition by way of the same mechanisms seen in renal stone formation. In support of the hypothesis of a connection between renal and salivary stone formation, a recent large case-control study of 3,864 patients in Taipei by Wu et al 26 reported a strong association of sialolithiasis with a history of nephrolithiasis, with an adjusted odds ratio of 4.74. If excess calcium from the oral environment assists in the formation of sialoliths, perhaps our patient's daily oral intake of calcium carbonate (1,000 mg) in a chewable form might have played a role in her salivary gland stone development.…”

Section: Discussionmentioning

confidence: 90%

“…First, she had no other known risk factors for sialolithiasis, including no history of diabetes, chronic renal disease, tobacco use, hypoparathyroidism, dehydration, poor oral hygiene, gout, or previous trauma to the salivary glands. 26 Second, the patient presented with cloudy urine with precipitate, suggesting decreased calcium solubility in excreted fluids. This change to the patient's urine occurred shortly after the initiation of the drug and reversed on its discontinuation.…”

Section: Discussionmentioning

confidence: 99%

Possible Drug-Associated Sialolithiasis From the Bicarbonate Anhydrase Inhibitor Topiramate: A Case Report and Literature Review

Buhler

Huynh

Low

et al. 2016

Journal of Oral and Maxillofacial Surgery

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“…Our previous studies have demonstrated associations between sialolithiasis and cholelithiasis as well as nephrolithiasis . Interestingly, it has long been reported that nephrolithiasis is associated with osteoporosis .…”

Section: Introductionmentioning

confidence: 96%

“…Our previous studies have demonstrated associations between sialolithiasis and cholelithiasis as well as nephrolithiasis. 7,8 Interestingly, it has long been reported that nephrolithiasis is associated with osteoporosis. [9][10][11][12][13][14] Little is known about the contribution of systemic predisposing factors to the development of sialolithiasis in the context of systemic calcium metabolism disorders, such as osteoporosis.…”

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confidence: 99%

A case‐control study of the association between sialolithiasis and osteoporosis

Hung

Xirasagar

Lin

2019

Clinical Otolaryngology

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Objective The purpose of this study was to evaluate the association between osteoporosis and salivary gland stone using a population‐based claims database. Design A case‐control design. Setting Taiwan. Participants We retrieved the sample for this case‐control study from the Taiwan “Longitudinal Health Insurance Database 2005.” All 557 patients aged 40 years or older with a diagnosis of sialolithiasis were cases, and 1671 matched controls (without sialolithiasis) were selected. Subjects and Methods We used the chi‐square test to explore differences between cases and controls on socio‐demographic characteristics. Furthermore, conditional logistic regressions were used to examine the association of sialolithiasis with previously diagnosed osteoporosis. Results Of 2228 sampled patients, 171 (7.68%) had ever been previously diagnosed with osteoporosis; 58 (10.41%) among cases and 113 (6.76%) among controls (P = 0.005). Conditional logistic regression analysis found that the odds ratio (OR) of prior osteoporosis for cases was 1.79 (95% confidence interval [CI]: 1.24‐2.59, P = 0.002) relative to controls after adjusting for urbanisation and the selected medical co‐morbidities. Furthermore, we found that among patients aged ≥65 years, the adjusted OR of prior osteoporosis for cases was 1.89 (95% CI = 1.02‐3.51). No significant relationship was observed among patients aged <65 years old. Conclusion This study demonstrates an association between sialolithiasis and osteoporosis. Although the finding warrants further investigation, the results call for more awareness of the possible concurrence of osteoporosis among physicians and patients with salivary gland stones.

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Sialolithiasis is associated with nephrolithiasis: a case-control study

Cited by 22 publications

References 11 publications

Increased risk of sialolithiasis in smokers: A nested case-control study using a national health screening

Increased risk of sialolithiasis in smokers: A nested case-control study using a national health screening

Possible Drug-Associated Sialolithiasis From the Bicarbonate Anhydrase Inhibitor Topiramate: A Case Report and Literature Review

A case‐control study of the association between sialolithiasis and osteoporosis

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