Sibling adaptation to childhood cancer collaborative study: Health outcomes of siblings of children with cancer

Zeltzer, Lonnie K.; Dolgin, Michael J.; Sahler, Olle Jane Z.; Roghmann, Klaus J.; Barbarin, Oscar A.; Carpenter, Paul J.; Copeland, Donna R.; Mulhern, Raymond K.; Sargent, Janice R.

doi:10.1002/(sici)1096-911x(199608)27:2<98::aid-mpo6>3.0.co;2-o

Cited by 74 publications

(54 citation statements)

References 15 publications

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“…TACQOL motor skills difficulties refer to problems in the areas of walking, standing, running, walking stairs, balance, playing, speed and stamina. Parallel to these findings, a higher incidence of somatic problems on the Child Behaviour Checklist (CBCL) was found in siblings of children with cancer in an US study (Zeltzer et al . 1996).…”

Section: Discussionmentioning

confidence: 73%

One month after diagnosis: quality of life, coping and previous functioning in siblings of children with cancer¹

Houtzager

Grootenhuis

Hoekstra-Weebers³

2005

Child

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During the first 2 months after the diagnosis of cancer in a brother or sister, siblings have relatively lower QoL than peers. Health problems that existed before diagnosis may be a predictor of later adjustment problems. Positive expectations about the course of the illness appear to protect siblings from distress. Information about the illness is a delicate issue that requires parental guidance.

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Section: Discussionmentioning

confidence: 73%

One month after diagnosis: quality of life, coping and previous functioning in siblings of children with cancer¹

Houtzager

Grootenhuis

Hoekstra-Weebers³

2005

Child

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“…Regarding control groups, siblings may represent a better control group than population norms due to both genetic and family-of-origin similarities. 39 However, it is possible that siblings are at an elevated risk of pain outcomes due to their experience of having a sibling with cancer. These factors may underestimate the difference between survivors and non-sibling controls.…”

Section: Ta B L E 1 (Continued)mentioning

confidence: 99%

A systematic review of self‐reported pain in childhood cancer survivors

Reinfjell

Zeltzer

2019

Acta Paediatrica

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Aim The aim of this systematic review was to examine the frequency and risk factors of pain among long‐term childhood cancer survivors based on self‐reported questionnaire studies. Participants aged 21 years or younger at the time of their cancer diagnosis were included. Methods The Medline (OVID), PubMed and PsycINFO databases were searched for manuscripts published between January 1, 1990, and August 31, 2018, following the PRISMA statement for reporting systematic reviews. Results In total, 25 studies, including five prospective cohort studies measuring pain up to 32 years post‐diagnosis, were identified. Female sex, young age at diagnosis, older age at assessment, greater time since diagnosis, specific diagnoses (such as central nervous system [CNS] tumours, bone tumours and sarcoma), fatigue and persistent emotional distress were associated with cancer‐related pain. The most common pain types were migraines, headaches and back pain. Conclusion A subset of childhood cancer survivors reported clinically significant self‐reported pain. Identifying survivor subgroups at risk for pain could be essential for developing tailored intervention and prevention strategies. Prospective studies that use standardised and psychometrically sound tools to evaluate pain are needed.

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“…Research with siblings of children on active therapy for cancer demonstrates impaired psychosocial health [5][6][7][8][9][10][11][12][13]. Unfortunately, little is known about these siblings when they reach adulthood and the child with cancer is a long-term survivor [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Psychological outcomes of siblings of cancer survivors: a report from the Childhood Cancer Survivor Study

et al. 2010

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Objective To identify risk factors for adverse psychological outcomes among adult siblings of long-term survivors of childhood cancer. Methods Cross-sectional, self-report data from 3,083 adult siblings (mean age 29 years, range 18-56 years) of 5+ year survivors of childhood cancer were analyzed to assess psychological outcomes as measured by the Brief Symptom Inventory-18 (BSI-18). Sociodemographic and health data, reported by both the siblings and their matched cancer survivors were explored as risk factors for adverse sibling psychological outcomes through multivariable logistic regression. Results Self-reported symptoms of psychological distress, as measured by the global severity index of the BSI-18, were reported by 3.8% of the sibling sample. Less than 1.5% of siblings reported elevated scores on two or more of the subscales of the BSI-18. Risk factors for sibling depression included having a survivor brother (OR 2.22, 95% CI 1.42-3.55), and having a survivor with impaired general health (OR 2.15, 95% CI 1.18-3.78). Siblings who were younger than the survivor reported increased global psychological distress (OR 1.81, 95% CI 1.05-3.12), as did siblings of survivors reporting global psychological distress (OR 2.32, 95% CI 1.08-4.59). Siblings of sarcoma survivors reported more somatization than did siblings of leukemia survivors (OR 2.07, 95% CI 1.05-3.98). Conclusions These findings suggest that siblings of long-term childhood cancer survivors are psychologically healthy in general. There are, however, small subgroups of siblings at risk for long-term psychological impairment who may benefit from preventive risk-reduction strategies during childhood while their sibling with cancer is undergoing treatment.

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Sibling adaptation to childhood cancer collaborative study: Health outcomes of siblings of children with cancer

Cited by 74 publications

References 15 publications

One month after diagnosis: quality of life, coping and previous functioning in siblings of children with cancer¹

One month after diagnosis: quality of life, coping and previous functioning in siblings of children with cancer¹

A systematic review of self‐reported pain in childhood cancer survivors

Psychological outcomes of siblings of cancer survivors: a report from the Childhood Cancer Survivor Study

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Sibling adaptation to childhood cancer collaborative study: Health outcomes of siblings of children with cancer

Cited by 74 publications

References 15 publications

One month after diagnosis: quality of life, coping and previous functioning in siblings of children with cancer1

One month after diagnosis: quality of life, coping and previous functioning in siblings of children with cancer1

A systematic review of self‐reported pain in childhood cancer survivors

Psychological outcomes of siblings of cancer survivors: a report from the Childhood Cancer Survivor Study

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Product

Resources

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One month after diagnosis: quality of life, coping and previous functioning in siblings of children with cancer¹

One month after diagnosis: quality of life, coping and previous functioning in siblings of children with cancer¹