Sibutramine Associated Cardiac Arrest in a Chinese Healthy Young Lady

Lam, SK; Wong, OF; Fung, HT; Yam, PW

doi:10.1177/102490791302000107

Cited by 3 publications

(1 citation statement)

References 10 publications

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“…Since sibutramine is still commonly found as additive in slimming medications available on the internet or over-the-counter [24] despite the retraction of FDA approval, this study was aimed at determining the effects of sibutramine on blood coagulation and consequently the role in cardiovascular complications often observed in prolonged sibutramine use. In particular, the effects of sibutramine on platelets and fibrin networks were evaluated.…”

Section: Resultsmentioning

confidence: 99%

The Effect of Sibutramine, a Serotonin-Norepinephrine Reuptake Inhibitor, on Platelets and Fibrin Networks of Male Sprague-Dawley Rats: A Descriptive Study

Schoor¹,

Oberholzer²,

Bester³

et al. 2014

Ultrastructural Pathology

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Sibutramine is used in the treatment of obesity due to its ability to influence feelings of hunger and satiety by inhibiting the re-uptake of serotonin and noradrenalin in the central nervous system (CNS). Sibutramine use has been associated with numerous adverse events in particular cardiovascular complications possibly due to the formation of thrombi. This ultrastructural descriptive study investigated the effect of sibutramine on blood coagulation, specifically the effect on morphology of platelets and fibrin networks using scanning electron microscopy. Male Sprague-Dawley rats treated with either a recommended therapeutic dose [low dosage 1.32 mg/kg] or a toxicological higher dose [high dosage 13.2 mg/kg] of sibutramine for 28 days were used and compared to control animals. Blood samples were collected and plasma smears were prepared for platelet evaluation. Following the addition of thrombin to the plasma samples, the morphology of the fibrin clots was evaluated. Platelet evaluation by scanning electron microscopy revealed morphology typical of a prothrombotic state with a characteristic excessive platelet activation in both low-dose (LD) and high-dose (HD) rats. The fibrin clots of sibutramine-treated rats, LD and HD revealed fused thick fibers with thin fibers forming a netlike structure over the thick fibers which differ considerably from the organized structure of the control animals. It can be concluded that sibutramine alters the ultrastructure of platelets and fibrin networks creating a prothrombotic state.

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Section: Resultsmentioning

confidence: 99%