SiC Nanowire-Based Transistors for Electrical DNA Detection

Bano, Edwige; Fradetal, Louis; Ollivier, M.; Choi, Jihoon; Stambouli, Valérie

doi:10.1016/b978-0-12-802993-0.00009-5

Cited by 4 publications

(11 citation statements)

References 80 publications

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“…In parallel, SiC nanostructures have shown potential towards chemical sensors 14,15 , transistors for deoxyribonucleic acid (DNA)/ribonucleic acid (RNA) detection 16,17 , photodynamic therapy 18 and implantable scaffolds for tissue regeneration. 19 The coupling of favourable electrical and optical/plasmonic properties of graphene with exceptional mechanical properties of SiC nanowires (NWs) could result in a hybrid biocompatible nanomaterial for next generation biosensors.…”

Section: Introductionmentioning

confidence: 99%

Growth of graphitic carbon layers around silicon carbide nanowires

Mishra

Bosi

Rossi

et al. 2019

Journal of Applied Physics

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We demonstrate the ability to synthesize graphitic carbon sheets around cubic silicon carbide nanowires via an alloy-mediated catalytic process. The transmission electron microscopy analysis shows multilayer graphitic carbon sheets with a large interatomic layer distance of ~0.45nm, suggesting the presence of oxygen in the graphitic system. Oxygenrelated peaks observed by energy-dispersive X-ray spectroscopy, Raman spectroscopy and Fourier-transform infrared spectroscopy further confirm the oxidation of the graphitic carbon layers. A detailed investigation of the Raman spectra reveals a turbostratic stacking of the graphitic carbon layers. The turbostratic nature and the presence of oxidation in the graphitic carbon surrounding the silicon carbide nanowires makes them a suitable platform for further functionalisation, of particular interest for bio-sensing, as both graphitic carbon and silicon carbide are bio-compatible.

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Section: Introductionmentioning

confidence: 99%

Growth of graphitic carbon layers around silicon carbide nanowires

Mishra

Bosi

Rossi

et al. 2019

Journal of Applied Physics

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“…Nanowire field effect transistors (nanowire-FETs) are one of the promising bio-sensing techniques and have rigorously been investigated [ 2 , 20 , 21 , 23 , 24 , 46 , 47 ]. These devices offer unique advantages, such as real-time and label-free detection [ 63 ] and high sensitivities for biomolecules such as DNA, RNA, proteins, and ions at femtomolar levels [ 5 , 64 , 65 ].…”

Section: Sic Dna-sensing Technologiesmentioning

confidence: 99%

“…However, Si can undergo chemical reactions in the body’s environment and is therefore not biocompatible [ 6 , 7 , 8 , 9 ] and suffers from instability in long-term uses in biological media and aqueous solutions, resulting in low signal-to-noise ratio and sensor performance issues [ 2 , 10 , 11 , 12 ]. Researchers have been exploring other materials for DNA sensing which are biocompatible, chemically inert and robust, and nontoxic to biomedical environments, such as gallium nitride (GaN) [ 5 ], carbon nanotubes (CNTs) [ 13 , 14 , 15 ], graphene [ 16 , 17 ], silicon carbide (SiC) [ 1 , 2 , 10 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ], etc. Among them, SiC is one of the most promising materials for DNA sensing.…”

Section: Introductionmentioning

confidence: 99%

“…Recently SiC-based biosensors have been studied to explore their potential for DNA sensing, with six main technologies reported in the literature. These technologies include: (1) aptamer-modified SiC nanoparticles and quantum dots as fluorescent aptasensor [ 18 , 25 , 45 ], (2) silicon carbide nanoparticle-modified glassy carbon electrode [ 1 ], (3) bio-functionalized SiC nanopillar arrays [ 10 , 23 ], (4) bio-functionalized nanowires [ 19 ], (5) nanowire-based field effect transistor [ 2 , 20 , 21 , 23 , 24 , 46 , 47 ], and (6) nanocrystalline 3C-SiC electrodes [ 22 , 41 , 48 , 49 , 50 ]. This paper presents a concise review of these six SiC-based DNA sensing technologies.…”

Section: Introductionmentioning

confidence: 99%

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Silicon Carbide-Based DNA Sensing Technologies

et al. 2023

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DNA sensing is critical in various applications such as the early diagnosis of diseases and the investigation of forensic evidence, food processing, agriculture, environmental protection, etc. As a wide-bandgap semiconductor with excellent chemical, physical, electrical, and biocompatible properties, silicon carbide (SiC) is a promising material for DNA sensors. In recent years, a variety of SiC-based DNA-sensing technologies have been reported, such as nanoparticles and quantum dots, nanowires, nanopillars, and nanowire-based field-effect-transistors, etc. This article aims to provide a review of SiC-based DNA sensing technologies, their functions, and testing results.

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“…[1, 2] SiC is a wide bandgap semiconductor with high breakdown electric field strength, high saturated electrons’ drift velocity and a high thermal conductivity. [3] Due to these unique electrical properties, SiC has become a promising bio-sensor for a variety of medical applications[4–6] including glucose sensing,[7] DNA detection,[8] and neural probing. [9] SiC is also used to coat medical devices and implants due to its excellent strength, low density (in comparison with metals), stability, and chemical inertness.…”

Section: Introductionmentioning

confidence: 99%

Cellular toxicity of silicon carbide nanomaterials as a function of morphology

Chen

Zhao

et al. 2018

Biomaterials

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Silicon carbide has been shown to be biocompatible and is used as a coating material for implanted medical devices to prevent biofilms. Silicon carbide nanomaterials are also promising in cell tracking due to their stable and strong luminescence, but more comprehensive studies of this material on the nanoscale are needed. Here, we studied the toxicity of silicon carbide nanomaterials on human mesenchymal stem cells in terms of metabolism, viability, adhesion, proliferation, migration, oxidative stress, and differentiation ability. We compared two different shapes and found that silicon carbide nanowires are toxic to human mesenchymal stem cells but not to cancer cell lines at the concentration of 0.1 mg/mL. Control silicon carbide nanoparticles were biocompatible to human mesenchymal stem cells at 0.1 mg/mL. We studied the potential mechanistic effect of silicon carbide nanowires on human mesenchymal stem cells' phenotype, cytokine secretion, and gene expression. These findings suggest that the toxic effect of silicon carbide nanomaterials to human mesenchymal stem cells are dependent on morphology.

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SiC Nanowire-Based Transistors for Electrical DNA Detection

Cited by 4 publications

References 80 publications

Growth of graphitic carbon layers around silicon carbide nanowires

Growth of graphitic carbon layers around silicon carbide nanowires

Silicon Carbide-Based DNA Sensing Technologies

Cellular toxicity of silicon carbide nanomaterials as a function of morphology

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