Sicca symptoms are associated with similar fatigue, anxiety, depression, and quality-of-life impairments in patients with and without primary Sjögren's syndrome

Milin, Morgane; Cornec, Divi; Chastaing, M.; Griner, Véronique; Berrouiguet, Sofian; Nowak, Emmanuel; Marhadour, Thierry; Saraux, Alain; Devauchelle‐Pensec, Valérie

doi:10.1016/j.jbspin.2015.10.005

Cited by 65 publications

(43 citation statements)

References 32 publications

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“…Three studies12,24,26 made comparisons between the PCS in pSS patients and controls. Patients with pSS had significantly lower values (MD, −12.34; 95% CI: −18.42, −6.26; P <0.0001), with heterogeneity among studies ( P =0.0008) and I 2 =86%.…”

Section: Resultsmentioning

confidence: 99%

Sjögren’s syndrome is associated with negatively variable impacts on domains of health-related quality of life: evidence from Short Form 36 questionnaire and a meta-analysis

Zhang¹,

Wang²,

Chen³

et al. 2017

PPA

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PurposeThe purpose of this article was to systematically review the literature to identify the impact of primary Sjögren’s syndrome (pSS) on specific health-related quality of life (HRQoL) domains.MethodsA meta-analysis was performed, and the related articles were searched in Medline, Embase, Cochrane Library, China National Knowledge Infrastructure, China Biology Medicine, and Web of Science databases and in reference lists of articles and systematic reviews. Score of the Short Form 36 (SF-36) questionnaire was used as the outcome measurement, and mean differences (MD) with 95% confidence intervals (CIs) were calculated.ResultsSeven studies were included, comprising 521 patients with pSS and 9,916 healthy controls. The SF-36 questionnaire score of each domain (physical function, role physical [RP] function, emotional role function, vitality, mental health, social function, body pain, general health, physical component scale, mental component scale) was lower in patients with pSS than in healthy controls, especially the score in the dimension of RP function.ConclusionThis meta-analysis showed that patients had lower pSS score in each dimension of the SF-36, mostly in the RP function. This demonstrated that targeted interventions should be carried out to improve the HRQoL of pSS patients.

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Section: Resultsmentioning

confidence: 99%

Sjögren’s syndrome is associated with negatively variable impacts on domains of health-related quality of life: evidence from Short Form 36 questionnaire and a meta-analysis

Zhang¹,

Wang²,

Chen³

et al. 2017

PPA

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“…A study showed that 47% of the working age pSS patients received disability compensation, because they were considered to be (partially) unfit for work 47. The same study also reports that significantly more patients with the following demographic/disease characteristics receive disability compensation: male patients, patients with a high educational level, an increasing number of systemic manifestations and/or the use of artificial saliva and/or HCQ 40, 41, 47.…”

Section: Clinical Presentationmentioning

confidence: 98%

“…Additionally, sicca syndrome also includes hoarseness, non-productive cough, skin dryness and, in woman, dyspareunia 38, 39. Patients with pSS experience a significantly decreased quality of life compared to subjects with sicca syndrome without autoimmune features as measured by the SF-36 depression scale 40, 41.…”

Section: Clinical Presentationmentioning

confidence: 99%

Reviewing primary Sjögren's syndrome: beyond the dryness - From pathophysiology to diagnosis and treatment

Both¹,

Dalm²,

Hagen³

et al. 2017

Int. J. Med. Sci.

183

110

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Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease, characterized by lymphocytic infiltration of the secretory glands. This process leads to sicca syndrome, which is the combination of dryness of the eyes, oral cavity, pharynx, larynx and/or vagina. Extraglandular manifestations may also be prevalent in patients with pSS, including cutaneous, musculoskeletal, pulmonary, renal, hematological and neurological involvement. The pathogenesis of pSS is currently not well understood, but increased activation of B cells followed by immune complex formation and autoantibody production are thought to play important roles. pSS is diagnosed using the American-European consensus group (AECG) classification criteria which include subjective symptoms and objective tests such as histopathology and serology. The treatment of pSS warrants an organ based approach, for which local treatment (teardrops, moistures) and systemic therapy (including non-steroidal anti-inflammatory drugs (NSAIDs), glucocorticoids, disease-modifying antirheumatic drugs (DMARDS) and biologicals) can be considered. Biologicals used in the treatment of pSS mainly affect the total numbers of B cells (B cell depletion (Rituximab)) or target proteins required for B cell proliferation and/or activation (e.g. B cell activating factor (BAFF)) resulting in decreased B cell activity.The aim of this review is to provide physicians a general overview concerning the pathogenesis, diagnosis and management of pSS patients.

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“…The chief treatment goal in chronic and usually non‐life‐threatening conditions such as primary SS is to improve the patient's perceived health‐related quality of life (HRQOL). HRQOL is profoundly impaired in primary SS . Therefore, the principal factors governing HRQOL impairment must be identified so that they can be specifically targeted by therapeutic interventions, to improve the patient's everyday experience.…”

Section: Introductionmentioning

confidence: 99%

Severe Health‐Related Quality of Life Impairment in Active Primary Sjögren's Syndrome and Patient‐Reported Outcomes: Data From a Large Therapeutic Trial

Cornec

Devauchelle‐Pensec

Mariette

et al. 2017

Arthritis Care & Research

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Sicca symptoms are associated with similar fatigue, anxiety, depression, and quality-of-life impairments in patients with and without primary Sjögren's syndrome

Cited by 65 publications

References 32 publications

Sjögren’s syndrome is associated with negatively variable impacts on domains of health-related quality of life: evidence from Short Form 36 questionnaire and a meta-analysis

Sjögren’s syndrome is associated with negatively variable impacts on domains of health-related quality of life: evidence from Short Form 36 questionnaire and a meta-analysis

Reviewing primary Sjögren's syndrome: beyond the dryness - From pathophysiology to diagnosis and treatment

Severe Health‐Related Quality of Life Impairment in Active Primary Sjögren's Syndrome and Patient‐Reported Outcomes: Data From a Large Therapeutic Trial

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Sicca symptoms are associated with similar fatigue, anxiety, depression, and quality-of-life impairments in patients with and without primary Sjögren's syndrome

Cited by 65 publications

References 32 publications

Sj&ouml;gren&rsquo;s syndrome is associated with negatively variable impacts on domains of health-related quality of life: evidence from Short Form 36 questionnaire and a meta-analysis

Sj&ouml;gren&rsquo;s syndrome is associated with negatively variable impacts on domains of health-related quality of life: evidence from Short Form 36 questionnaire and a meta-analysis

Reviewing primary Sjögren's syndrome: beyond the dryness - From pathophysiology to diagnosis and treatment

Severe Health‐Related Quality of Life Impairment in Active Primary Sjögren's Syndrome and Patient‐Reported Outcomes: Data From a Large Therapeutic Trial

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Product

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Sjögren’s syndrome is associated with negatively variable impacts on domains of health-related quality of life: evidence from Short Form 36 questionnaire and a meta-analysis

Sjögren’s syndrome is associated with negatively variable impacts on domains of health-related quality of life: evidence from Short Form 36 questionnaire and a meta-analysis