1992
DOI: 10.1097/01241398-199205000-00043
|View full text |Cite
|
Sign up to set email alerts
|

Sickle Cell Disease and Silent Avascular Necrosis of the Hip

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

0
30
0
2

Year Published

1996
1996
2020
2020

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 28 publications
(32 citation statements)
references
References 0 publications
0
30
0
2
Order By: Relevance
“…7 The only available prospective MRI study in adult SCD patients was that of Ware et al, who studied 27 patients aged 18 to 68 years and found evidence of AVNFH in 41%. 8 The factors predisposing SCD patients to AVNFH have not been fully elucidated, but coexistent ␣-thal trait, high hematocrit, and frequent vaso-occlusive crises may be important.…”
Section: Discussionmentioning
confidence: 99%
“…7 The only available prospective MRI study in adult SCD patients was that of Ware et al, who studied 27 patients aged 18 to 68 years and found evidence of AVNFH in 41%. 8 The factors predisposing SCD patients to AVNFH have not been fully elucidated, but coexistent ␣-thal trait, high hematocrit, and frequent vaso-occlusive crises may be important.…”
Section: Discussionmentioning
confidence: 99%
“…Thus, when retrospectively analyzed, few children without symptoms suspicious of hip ON received an MRI, although the majority had received hip XRs, and the remainder had no imaging and were considered controls based on the absence of symptoms suspicious for ON. While MRI is the gold-standard for detecting ON from all causes [33, 34], in asymptomatic SCD others have found MRI had no advantage over XR as a screening tool for ON of the hip [35]. Our study, with 15% of cases found to have stage I disease, similarly defined by Steinberg [24] and Ficat [21] as an abnormal MRI and normal XR (Table 2), supports MRI as the best tool for diagnosis of ON of the hip among children with SCD.…”
Section: Discussionmentioning
confidence: 99%
“…Infarcts within bone are considered clinically silent and tend to be discovered incidentally by conventional radiological scans, such as monochromatic x-rays [Ware et al, 1991]. The hypoxic nature of the bone marrow microenvironment promotes erythrocyte sickling and necrosis [Smith, 1996].…”
Section: Introductionmentioning
confidence: 99%