Sickle cell disease, update on management

Cope, Amanda; Darbyshire, P J

doi:10.1016/j.paed.2013.04.014

Cited by 5 publications

(2 citation statements)

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“…Sickle cell anemia is now the world's most common genetic defects. About 5% of the population carry a haemoglobinopathy trait worldwide, there are about 300,000 born annually worldwide with hemoglobin disorder [18]. Despite the significant increase in research and number of published articles on SCA and its complications remain elusive [19].…”

Section: Discussionmentioning

confidence: 99%

Immunology and Systemic Inflammation Biomarkers Among Saudi Patients with Sickle Cell Anemia in Asymptomatic Steady State Condition

Al-Sharif¹

2017

CRDOJ

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Background & Objective: Sickle cell anemia (SCA) comprises an inherited blood disorder that is lifelong and affects many people globally. Despite progress in therapy, SCA is a considerable cause of mortality and morbidity. This study was designed to measure the immunological parameters and inflammatory cytokines of Saudi patients with sickle cell anemia (SCA) in asymptomatic steady state.Material and Methods: Fifty asymptomatic sickle cell anemia patients and fifty age-and sex-matched healthy non-sickle cell disease subjects were involved in this study. Results:The number of white blood cells, neutrophil, lymphocytes, eosinophils, basophils, CD3, CD4 and CD8 count were significantly elevated in stable-state SCA patients when compared with healthy controls. In addition, the mean value of CRP, TNF-α, IL-2, IL-4, IL-6 and IL-8 were significantly elevated in stable-state SCApatients when compared with healthy controls. Conclusion:High levels of serum cytokines and immune system activation are evident in Saudi SCA patients in asymptomatic steady state.

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Section: Discussionmentioning

confidence: 99%

Immunology and Systemic Inflammation Biomarkers Among Saudi Patients with Sickle Cell Anemia in Asymptomatic Steady State Condition

Al-Sharif¹

2017

CRDOJ

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“…Sickle cell anemia (SCA) is now the world's most common genetic defect. It is estimated that 5% of the population carries a haemoglobinopathy trait worldwide, there are an estimated 300,000 babies born annually worldwide with a severe hemoglobin disorder 1 . Despite the significant increase in research and number of published articles, many aspects of the pathophysiology of the disease and its complications remain elusive 2 .…”

Section: Introductionmentioning

confidence: 99%

Impact of aerobic exercises on selected inflammatory markers and immune system response among patients with sickle cell anemia in asymptomatic steady state

El-Kader¹,

Al-Shreef²

2018

Afr H. Sci.

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Background & objectiveSickle cell anemia (SCA) is well recognized as a chronic inflammatory disease. Despite progress in therapy, SCA remains a cause of significant morbidity and mortality. The relationship between exercise and immune function has been of great interest to the scientific community and the lay public. The aim of this study was to measure the impact of aerobic exercise training on the immunologic parameters and inflammatory cytokines of patients with sickle cell anemia (SCA) in asymptomatic steady state.Material and methodsSixty asymptomatic sickle cell anemia patients were involved in this study, their age ranged from 25– 40 years and were assigned to two sub-groups; group (A) received aerobic exercise training for 12 weeks, however group (B) received no training intervention for 12 weeks. Parameters of CD3, CD4 and CD8 were quantified, Leukocyte, differential counts, IL-6 and TNF-α were measured before and after 12 weeks, at the end of the study.ResultsThe mean values of CD3, CD4 and CD8, leukocyte, monocytes counts, IL-6 and TNF-α were significantly decreased in group (A), while group (B) showed non-significant changes in these parameters. Also; there were significant differences between mean levels of the investigated parameters in group (A) and group (B) after treatment.ConclusionThe current study provides evidence that aerobic exercise training improves inflammatory markers and immune system in patients with sickle cell anemia (SCA) in asymptomatic steady state.

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Considérations périopératoires pour les patients atteints d’anémie falciforme : un compte rendu narratif

Khurmi

Gorlin

Misra

2017

Can J Anesth/J Can Anesth

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Sickle cell disease, update on management

Cited by 5 publications

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Immunology and Systemic Inflammation Biomarkers Among Saudi Patients with Sickle Cell Anemia in Asymptomatic Steady State Condition

Immunology and Systemic Inflammation Biomarkers Among Saudi Patients with Sickle Cell Anemia in Asymptomatic Steady State Condition

Impact of aerobic exercises on selected inflammatory markers and immune system response among patients with sickle cell anemia in asymptomatic steady state

Considérations périopératoires pour les patients atteints d’anémie falciforme : un compte rendu narratif

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