Sickle-cell Trait in Southern India

Lehmann, H.; Cutbush, Marie

doi:10.1136/bmj.1.4755.404

Cited by 153 publications

(79 citation statements)

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“…6 In India, the Haemoglobin S (HbS) was first detected in the Vedeloid tribes in the Nilgiri hills of Tamil Nadu and it was later discovered in other tribes also like the Veddian tribes of south, tribes of western India, labor tribes of Orissa and Assam, certain tribes of Marathi. 7,8 Its incidence varies from 5 to 34 % and it is mainly restricted to the tribal population. 9 In spite of much improvement in treatment, life survival is still associated with high morbidity and mortality.…”

Section: Introductionmentioning

confidence: 99%

Death due to sickle cell anaemia, an autopsy diagnosis: a study at a tertiary care hospital

2015

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Section: Introductionmentioning

confidence: 99%

Death due to sickle cell anaemia, an autopsy diagnosis: a study at a tertiary care hospital

2015

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“…2 In India the Hemoglobin S (Hb S) was first detected in Veddoid tribe in Nilgiri hills of Tamilnadu and later discovered in other states. 3 The incidence varies from 5 % to 34 % and it is mainly restricted to the tribal population. 4 High prevalence of sickle gene has been demonstrated in various tribal communities of Gujarat including Bhils and Dhodias of Panchmahal, Dublas, Naikas, Koli, Dhanka, Gamit, Vasava, Bariya, Varli, Vaghari, Kukna, Halpati, & Chaudhari.…”

Section: Introductionmentioning

confidence: 99%

Sickle cell disease status among school adolescents and their tribal community in South Gujarat

Vasava¹,

Chudasama²,

Godara³

et al. 2010

IJPN

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Abstract:Objectives: to create awareness, to screen samples of school adolescents and then to reach their community through them by doing surveillance for sickle cell disease. Design: Field based cross-sectional study. Settings: St Xavier`s high school and Vanraj high school of Umarpada taluka of Surat district. Subjects: School adolescents, their parents and friends. Method: After taking permission from school authority, blood samples of 948 school adolescents were taken for DTT test and then for electrophoresis. Blood samples of motivated parents and friends of those adolescents found positive for DTT was taken in subsequent visit and results were communicated to them. Results: Blood samples of 948 school adolescents, out of 1081 were tested for DTT test. It was positive in 242 samples, giving a prevalence of 25.5% for sickle cell disease. On subjecting the positive blood samples to electrophoresis, the proportion of sickle cell trait and sickle cell disease was found to be 92% and 8% respectively. Then electrophoresis was done in 64 parents and friends, 24 (37.5%) of them were found positive of which, 14 (58%) were having sickle cell trait and 10 (42%) having sickle cell disease. Conclusion: approaching community can be possible through school adolescents for conduction of surveillance of sickle cell anemia.

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“…2 The highest prevalence of HbS is in tropical Africa and among blacks in countries that participated in the slave trade with a lower frequency in the Mediterranean basin, Saudi Arabia, and parts of India. 3 Red cells containing HbS acquire the sickle-shape deformity upon deoxygenation because of the intracellular polymerization of Haemoglobin. Both Haemoglobin polymerization and membrane injury contribute to the pathophysiology of the sickling syndromes and haemolysis.…”

Section: Introductionmentioning

confidence: 99%