Sickness behaviors (reduced social interaction and pain behaviors) are linked to inflammatory mechanisms in a rat model of work-related musculoskeletal disorders

Barbe, MF; Xin, Derr; Hadrévi, Jenny; Elliott, ME; Barr-Gillespie, Ann E.

doi:10.1177/1541931213601225

Cited by 2 publications

(2 citation statements)

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“…As predicted, we found that MH calves exhibited some changes in social behavior and were less likely to initiate social grooming. Barbe et al (2016) also described reduced active social interactions, including sniffing and grooming, in a rat model of voluntary overwork leading to increased inflammatory cytokines. Reductions in social interactions may be indicative of either general lethargy or a motivation for social isolation during disease.…”

Section: Discussionmentioning

confidence: 92%

Behavioral changes in group-housed dairy calves infected with Mannheimia haemolytica

Hixson

Krawczel

Caldwell

et al. 2018

Journal of Dairy Science

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Monitoring sickness behavior may improve identification, management, and welfare of sick animals. The objective of this study was to characterize components of sickness behavior in group-housed dairy calves, using an experimental disease challenge model with Mannheimia haemolytica (MH). Holstein bull calves (aged 3-7 weeks; 58.0 ± 12.0 kg of body weight) were group-housed based on age and body weight in sand-bedded pens (6 calves/pen, 6.6 m 2 /calf) and provided pasteurized waste milk (8 L/d) 2× /d and grain concentrate ad libitum. Within group, calves were randomly assigned to 1 of 2 treatments: (1) inoculation at the tracheal bifurcation with 3 × 10 9 cfu of MH suspended in 5 mL of sterile phosphate buffered saline (PBS) followed by a 120 mL wash PBS (MH; n = 12, 3/pen), or (2) inoculation with 5 mL + 120 mL of sterile PBS only (control; n = 12, 3/pen). Rectal temperature and health scores were collected from d 0 to +6 of the challenge. A range of behaviors, including feeding patterns and social interactions, were recorded from video from d 0 to +2. The challenge model resulted in calves experiencing a mild disease state: rectal temperatures of MH calves were elevated throughout the challenge compared with control calves, peaking at 12 h postinoculation (39.2 vs. 38.9°C; standard error = 0.14). Many behavioral responses were subject to treatment by day effects, with calves generally becoming less active following inoculation with MH and then returning to baseline. Affected behaviors surrounding feeding included milk feeding time, frequency of competitive displacements, and concentrate feeding time. Lying time was similarly subject to treatment by day effects, and MH calves also spent more time lying on their left side compared with their right (604 vs. 471 min/h; standard error = 32), whereas control calves expressed no laterality.Duration of social lying did not differ, but frequency of social lying bouts decreased in MH calves following inoculation (0.44 vs. 0.75 bouts/h; standard error = 0.04). Social grooming was initiated less by MH calves (0.78 vs. 1.96 min/h; standard error = 0.38), but they tended to receive more social grooming for a greater duration of time (1.59 vs. 1.25 min/h; standard error = 0.13). Overall, we found that infected calves exhibited reduced grooming, feeding, and social interactions, suggesting that these behavioral changes may be useful indicators of early stages of respiratory disease.

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Section: Discussionmentioning

confidence: 92%

Behavioral changes in group-housed dairy calves infected with Mannheimia haemolytica

Hixson

Krawczel

Caldwell

et al. 2018

Journal of Dairy Science

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“…However, results from animal experiments suggest that inflammatory mechanisms may be the underlying cause or at least contribute to symptoms such as depression, anxiety, hyperalgesia, a decline in confidence and problem solving ability, reduced social interaction and pain behaviours [72,76]. What has become evident is the fact that psychological factors may worsen the symptoms of work-related musculoskeletal disorders, and indications are that it may sometimes be the primary cause of the symptoms [72,77].…”

Section: Work-related Musculoskeletal Disordersmentioning

confidence: 99%

Low-grade systemic inflammation and the workplace

Viljoen

Negrao

2021

WOR

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BACKGROUND: Psychosocial and physical stressors can elicit the stress response, co-ordinated by interactions between neuroendocrine and inflammatory processes. The central role of the immune system, specifically low-grade systemic inflammation, is sometimes overlooked in work-related stress research. OBJECTIVE: To review evidence that work-related psychosocial and physical stressors can stimulate a low-grade systemic inflammation which, through interactions with the neurohormonal systems, may impact on the well-being and productivity of workers. METHODS: Literature searches were performed by databases and by hand. Databases used included Interface - EBSCOhost Research Databases; PsycINFO; Academic Search Complete; Africa-Wide Information; CINAHL; E-Journals; MEDLINE and PsycARTICLES. RESULTS: Psychosocial stressors, infections, poor indoor air quality, musculoskeletal injuries and chemicals can stimulate a low-grade systemic inflammation that may adversely affect workers’ mental and physical health, as well as productivity. The psychological and physical effects caused by infection-induced inflammation are generally referred to as sickness behaviour and those caused by poor indoor air quality as sick building syndrome. CONCLUSIONS: Stressor-induced low-grade systemic inflammation can be a causal factor in the physical and behavioural symptoms of work-related stress. It is therefore important that those involved with the health of workers be cognisant of inappropriate or chronic low-grade inflammation as a potential health hazard.

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Sickness behaviors (reduced social interaction and pain behaviors) are linked to inflammatory mechanisms in a rat model of work-related musculoskeletal disorders

Cited by 2 publications

References 27 publications

Behavioral changes in group-housed dairy calves infected with Mannheimia haemolytica

Behavioral changes in group-housed dairy calves infected with Mannheimia haemolytica

Low-grade systemic inflammation and the workplace

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