Side-Effects of Acrylic Cement Implanted into Bone: A Histological, (Micro)Angiographic, Fluorescence-Microscopic and Autoradiographic Study in the Rabbit Femur

Influence of Cooling on Curing Temperature Distribution During Cementing of Modular Cobalt-Chromium and Monoblock Polyethylene Acetabular Cups

“…In this context, it has to be mentioned that beside temperature the monomer release and vascular damage during imperfect polymerization might also play an important role for postoperative bone necrosis. [24][25][26][27] These factors could not be investigated and were beyond the focus of this study.…”

Material properties and in vitro biocompatibility of a newly developed bone cement

“…Obviously during application, the cement has not yet completely hardened, which may provoke adverse biological effects associated with the reaction mechanism as found for PMMA cements 5,29 . So, for testing biocompatibility of new biomaterials to bone cells In Vitro, it is important to use a method that matches the in vivo situation as closely as possible.…”

Decreased blood perfusion in canine tibial dia-physis after filling with acrylic bone cement compared with inert bone wax

“…Consequently, we found that a model for testing the biological response to cement must include a control operation with filling of the medullary cavity. Other authors have inserted a precured bone cement rod into the medullary cavity as a control (Feith 1975, Linder 1977. Such procedures cannot effectively fill the medullary cavity, because in a pilot series of 5 animals we found that if the medullary cavity was not completely filled with bone wax, a heavy, bluestained line occurred between the wax and the bone within a few weeks, indicating that the endosteal blood circulation had been reestablished.…”

“…Former studies on the effect on bone of intramedullary application of PMMA cement have all been dealing with a control operation consisting of removal of bone marrow (Feith 1975, Rhinelander et al 1979, Sund and Rosenquist 1983 without filling of the medullary cavity with an inert material. The blood supply to cortical bone is mainly derived from the medullary cavity (Brookes 1971, Rhinelander 1972, and thus the cortex becomes avascular when the bone marrow is removed Cavadias 1955, Danckwardt-Lilliestrom 1969), apart from a narrow rim just beneath the periosteum.…”

“…Bone damage after cementation of a prosthesis into tubular bone with acrylic (PMMA) bone cement might be caused by reaming of the medullary cavity (Danckwardt-Lilliestrom 1969, Rhinelander et al 1979, filling of the canal Rosenquist 1983, 1984), heat production during polymerization (Mjoberg 1986), and toxic effect of excessive monomer leakage (Feith 1975).…”