Side effects of local anesthetics

Grotticelli, Janet

doi:10.1016/bs.seda.2021.08.008

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…Topical anesthetics act on the peripheral nerves and reduce the sensation of pain at the site of application. However, adverse events such as allergy and local anesthetic systemic toxicity (LAST) have been associated with their usage [3], as well as side effects through overuse or overdose [4]. Frequently, they might trigger bad taste, a feeling of numbness in the mouth that may extend to the throat, which incites subjective repulsion and dissatisfaction and can lead to trouble swallowing or even choking [5].…”

Section: Introductionmentioning

confidence: 99%

“…Traditional common topical anesthetics used in dentistry and approved by Food and Drug Administration (FDA) contain lidocaine or benzocaine as active ingredients and are used in the form of solutions, creams, gels, and sprays [1,7]. Those agents have been thoroughly investigated, but with contrasting results [3]. It is also for this reason that alternative pretreatment of the site of injection to reduce side effects or costs such as phytotherapy [8], acupuncture and acupressure [9], transcutaneous electric nerve stimulation [10], tissue vibration [11], cryoanesthesia [12], and hypnosis [13] are described despite the lack of a univocal conclusion.…”

Section: Introductionmentioning

confidence: 99%

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The 1064-nm Nd:YAG Photobiomodulation vs. 20% Benzocaine Topical Gel in Inducing Mucosal Anesthetic Effect: A Double-Blind Randomized Clinical Trial

et al. 2022

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The periapical local anesthetic injection may be associated with fear of needles and pain administration. Dental topical anesthetic agents can help to reduce pain perception; however, adverse events can occur. To investigate the efficacy of 1064-nm photobiomodualtion (PBM) in inducing mucosal anesthesia delivered with a flat-top hand-piece compared to 20% Benzocaine topical anesthetic gel, sixty healthy patients were randomly allocated (1:1) to either 20% benzocaine topical gel + placebo laser (T group) or PBM + placebo gel (L group). The 1064-nm Nd:YAG laser was employed and is associated with a novel flat-top hand piece. The applied operational parameters were 0.5 W, 10 Hz, 100 µs pulse width, and 30 J/cm2 for one-minute single application time. The enrolled subjects were asked to assess pain intensity at the time of anesthetic injection with a Visual Analog Scale. Taking into consideration taste, undesirable numbness, and overall satisfaction, the patients were asked to rate their experiences according to a verbal rating scale. Statistical analysis showed no statistically significant difference between the T and L Groups for pain ratings (p = 0.0596). The L Group displayed significantly higher ratings than T Group for taste, undesirable numbness, and overall satisfaction (p < 0.001). The 1064-nm PBM delivered by flat-top hand piece is effective in inducing mucosal anesthesia, eliminating the adverse side-effects of the conventional topical anesthetic gel.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The 1064-nm Nd:YAG Photobiomodulation vs. 20% Benzocaine Topical Gel in Inducing Mucosal Anesthetic Effect: A Double-Blind Randomized Clinical Trial

et al. 2022

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Addressing the Needs of the Rapidly Aging Society through the Development of Multifunctional Bioactive Coatings for Orthopedic Applications

Mastnak

Maver

Finšgar

2022

IJMS

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The unprecedented aging of the world’s population will boost the need for orthopedic implants and expose their current limitations to a greater extent due to the medical complexity of elderly patients and longer indwelling times of the implanted materials. Biocompatible metals with multifunctional bioactive coatings promise to provide the means for the controlled and tailorable release of different medications for patient-specific treatment while prolonging the material’s lifespan and thus improving the surgical outcome. The objective of this work is to provide a review of several groups of biocompatible materials that might be utilized as constituents for the development of multifunctional bioactive coatings on metal materials with a focus on antimicrobial, pain-relieving, and anticoagulant properties. Moreover, the review presents a summary of medications used in clinical settings, the disadvantages of the commercially available products, and insight into the latest development strategies. For a more successful translation of such research into clinical practice, extensive knowledge of the chemical interactions between the components and a detailed understanding of the properties and mechanisms of biological matter are required. Moreover, the cost-efficiency of the surface treatment should be considered in the development process.

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Side effects of local anesthetics

Cited by 2 publications

References 19 publications

The 1064-nm Nd:YAG Photobiomodulation vs. 20% Benzocaine Topical Gel in Inducing Mucosal Anesthetic Effect: A Double-Blind Randomized Clinical Trial

The 1064-nm Nd:YAG Photobiomodulation vs. 20% Benzocaine Topical Gel in Inducing Mucosal Anesthetic Effect: A Double-Blind Randomized Clinical Trial

Addressing the Needs of the Rapidly Aging Society through the Development of Multifunctional Bioactive Coatings for Orthopedic Applications

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