Side-effects of quinolones: Comparisons between quinolones and other antibiotics

Norrby, S. Ragnar

doi:10.1007/bf01967014

Cited by 95 publications

(43 citation statements)

References 10 publications

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“…Toxicity of the fluoroquinolones is mild at therapeutic doses, and generally consists of gastrointestinal disturbances such as nausea, vomiting and diarrhea (Norrby, 1991). At slightly higher doses, CNS signs of dizziness, restlessness, headache, depression, somnolence or insomnia may be seen (Neu, 1988).…”

Section: Adverse Effectsmentioning

confidence: 99%

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Quinolones: a class of antimicrobial agents

Sárközy¹

2001

Vet. Med. - Czech

120

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ABSTRACT:The fluoroquinolones are a series of synthetic antibacterial agents that are used in the treatment of a variety of bacterial infections. These agents inhibit the DNA gyrase, abolishing its activity by interfering with the DNA-rejoining reaction. The inhibition of the resealing leads to the liberation of fragments that are subsequently destroyed by the bacterial exonucleases. All fluoroquinolones accumulate within bacteria very rapidly, so that a steady-state intrabacterial concentration is obtained within a few minutes. Resistance develops slowly and is usually chromosomal and not plasmid mediated. However, development of resistance and transfer between animal and human pathogens has become a fervently argued issue among the microbiologists. Another concern regarding the use of new quinolones in the veterinary field is a possible detrimental effect on the environment. It still seems unlikely that the controlled use of veterinary quinolones will give rise to unfavorable effects on the environment.

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Section: Adverse Effectsmentioning

confidence: 99%

“…Photosensitization occurs with all marketed fluoroquinolones, especially pefloxacin, although it is rare for norfloxacin and ciprofloxacin (Neu, 1988;Norrby, 1991). Topical administration to the eye shows less toxicity to the corneal epithelium than aminoglycosides (Cutarelli et al, 1991).…”

Section: Adverse Effectsmentioning

confidence: 99%

Quinolones: a class of antimicrobial agents

Sárközy¹

2001

Vet. Med. - Czech

120

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“…7 Another study involving ADRs to all classes of antibiotics reported to a peripheral pharmacovigilance center in India, over a 3-year period, showed that dermatological (47.4%) and gastrointestinal(39.3%) ADRs were the most prevalent. In few earlier studies insomnia has been reported in about 4.7% of patients treated with ofloxacin, while psychosis occurs in <1% of patients.…”

Section: Discussionmentioning

confidence: 99%

Monitoring, evaluation and comparison of adverse effect profile of ciprofloxacin and ofloxacin in acute bacterial exacerbation of chronic bronchitis patients attending pulmonology department of tertiary care teaching hospital: a prospective observational study

Kurli

2018

Int J Basic Clin Pharmacol

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Background: In 2016, FDA recommended that "serious side effects associated with flouroquinolones generally outweigh the benefits for the patients with acute sinusitis, acute bronchitis and uncomplicated UTI". Throughout India the most commonly used flouroquinolones for above conditions are Ciprofloxacin, Ofloxacin, and Levofloxacin. In this scenario, the present study was undertaken to monitor, evaluate and compare the adverse effect profile of Ciprofloxacin and Ofloxacin in acute exacerbation of chronic bronchitis patients. Methods: Prospective, observational study done in 200 patients of tertiary care teaching hospital. The patients diagnosed with, acute bronchitis treated with Ciprofloxacin 500mg BD or Ofloxacin 400mg BD for 7 days were included in the study. The study duration was 6 months. ADR causality assessment was done with Naranjo algorithm. Statistical test applied was chi-square test. Results: 63 ADR were reported in Ofloxacin group and 19 ADR in Ciprofloxacin group. Insomnia was most frequent ADR (40%) in patients treated with Ofloxacin. There is high incidence of ADRs in ofloxacin group. chi square test showed this difference is statistically significant (p<0.05). Insomnia was significantly higher in ofloxacin group (p<0.05). Conclusions: In India frequently used and misused antimicrobials are fluoroquinolones. The present study concluded that no serious ADRs but ofloxacin group of patients have shown increased incidence of ADRs associated with CNS especially Insomnia. However, further large scale, multi-centric studies are needed to confirm these results.

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“…Several reports described that the neurotoxic effect of FQAs treatment increased the frequency of epileptic seizures, hallucinations, and other severe CNS reactions (Segev et al, 1988;Christ et al, 1988;Carbon, 2001). The potential risk of PEF treatment increased when it was simultaneously administered with aminophyllins or nonsteroidal antiinflammatory drugs (Christ et al, 1988;Segev et al, 1988;Norrby, 1991). These clinical findings are in accordance with the results of animal experiments, when the proconvulsant activity of the FQAs was demonstrated in an epileptic model and the intraperitoneal administration of PEF-induced seizures in mice (De Sarro et al, 1994;De Sarro et al, 1997).…”

Section: Modification Of Innervation In Salivary Glandmentioning

confidence: 99%

Modification of Innervation Pattern by Fluoroquinolone Treatment in the Rat Salivary Glands

Kelentey

Deák

Zelles

et al. 2010

The Anatomical Record

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Fluoroquinolone antibiotics (FQAs) are widely used in dental and medical therapy. Despite their known severe adverse actions on the central and peripheral nervous system, little attention has been directed toward the potential toxic side effects of these compounds on the oral tissues. As the saliva secretion is controlled by the nervous system and neuropeptides, the neurotoxic effect of pefloxacin (PEF), a representative member of FQAs, was studied in rats in the present work. Previously, we demonstrated a significant weight loss of parotid gland tissue, a marked decrease in 3H-thymidine incorporation, a decreased volume of saliva and amylase activity of the glandular tissue in response to PEF. Animals received intraperitoneal injection of PEF (20 mg/100 g body weight daily) for 3 and 7 days. Normal histology, and neurofilament 200, substance P (SP) and calcitonin gene-related polypeptide (CGRP) containing nerve fibers were detected with immunohistochemical methods. A marked decrease of the weights in salivary glands and the acinar diameters were measured. Similarly, a strong and significant decrease of the number of SP and CGRP containing nerve fibers were detected. These findings suggest that the impaired morphology and innervation pattern of salivary glands is related to the neurotoxic adverse effect of FQA treatment. Anat Rec,

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Side-effects of quinolones: Comparisons between quinolones and other antibiotics

Cited by 95 publications

References 10 publications

Quinolones: a class of antimicrobial agents

Quinolones: a class of antimicrobial agents

Monitoring, evaluation and comparison of adverse effect profile of ciprofloxacin and ofloxacin in acute bacterial exacerbation of chronic bronchitis patients attending pulmonology department of tertiary care teaching hospital: a prospective observational study

Modification of Innervation Pattern by Fluoroquinolone Treatment in the Rat Salivary Glands

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