Side-gated ultrathin-channel nanopore FET sensors

Yanagi, Itaru; Oura, Takeshi; Haga, T.; Ando, Masahiko; Yamamoto, Jiro; Mine, T.; Ishida, Tadao; Hatano, Toshiyuki; Akahori, Rena; Yokoi, Takeshi; Anazawa, Takashi

doi:10.1088/0957-4484/27/11/115501

Cited by 7 publications

(6 citation statements)

References 54 publications

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“…The nanopore FET has been introduced and experimentally demonstrated in 2012 (21) and since then different implementations have been investigated (22)(23)(24)(25)(26)(27). The nanopore FET's primary device-level advantage is its potential high > 100 MHz bandwidth with sufficient signal-to-noise ratio (SNR).…”

Section: Ecs Transactions 111 (1) 235-247 (2023)mentioning

confidence: 99%

(Invited) BioFETs and Nanopore FETs: Nanoscale Silicon Field-Effect Transistors for Single-Molecule Sensing

Martens¹,

Barge²,

Liu³

et al. 2023

ECS Trans.

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High read throughput single-molecule sensing is a cornerstone of established third generation long-read DNA sequencing technologies and is crucial for emerging protein sequencing technologies. These omics technologies are of great interest for essential understanding and applications in the life sciences. Field Effect Transistor (FET)-based single-molecule sensors promise advances in omics, by further enhancing read throughput with massive parallelization. Here an overview is given of our recent progress on nanoscale bioFETs and nanopore FETs (NPFETs).

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Section: Ecs Transactions 111 (1) 235-247 (2023)mentioning

confidence: 99%

(Invited) BioFETs and Nanopore FETs: Nanoscale Silicon Field-Effect Transistors for Single-Molecule Sensing

Martens¹,

Barge²,

Liu³

et al. 2023

ECS Trans.

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“…Yanagi et al fabricated a side-gated nanopore FET to detect the four types of nucleotides by detecting the changes in the channel current when the DNA translocates through the nanopore [ 67 ]. They were also able to see that the current changes in the FET’s channel and the ionic current through the nanopore were in a synchronized pattern when the DNA translocated through the nanopore.…”

Section: Vlsi Architectures In Dna Detectionmentioning

confidence: 99%

VLSI Structures for DNA Sequencing—A Survey

2020

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DNA sequencing is a critical functionality in biomedical research, and technical advances that improve it have important implications for human health. Novel methods by which sequencing can be accomplished in more accurate, high-throughput, and faster ways are in development. Here, we review VLSI biosensors for nucleotide detection and DNA sequencing. Implementation strategies are discussed and split into function-specific architectures that are presented for reported design examples from the literature. Lastly, we briefly introduce a new approach to sequencing using Gate All-Around (GAA) nanowire Metal Oxide Semiconductor Field Effect Transistors (MOSFETs) that has significant implications for the field.

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“…This work will focus on sensing through this resistance-based mechanism. Iterations on the NP-FET concept, that were accomplished experimentally, tend to focus on very thin membranes in silicon, graphene, , or molybdenum disulfide (MoS 2 ) . The thinness of the membranes and channels involved allows for sequencing applications that require subnanometer-length resolution.…”

Section: Introductionmentioning

confidence: 99%

Design Principles of DNA-Barcodes for Nanopore-FET Readout, Based on Molecular Dynamics and TCAD Simulations

Voorspoels,

Gevers,

Santermans

et al. 2024

J. Phys. Chem. A

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Nanopore field-effect transistor (NP-FET) devices hold great promise as sensitive single-molecule sensors, which provide CMOS-based on-chip readout and are also highly amenable to parallelization. A plethora of applications will therefore benefit from NP-FET technology, such as large-scale molecular analysis (e.g., proteomics). Due to its potential for parallelization, the NP-FET looks particularly well-suited for the high-throughput readout of DNA-based barcodes. However, to date, no study exists that unravels the bit-rate capabilities of NP-FET devices. In this paper, we design DNA-based barcodes by labeling a piece of double-stranded DNA with dumbbell-like DNA structures. We explore the impact of both the size of the dumbbells and their spacing on achievable bit-rates. The conformational fluctuations of this DNA-origami, as observed by molecular dynamics (MD) simulation, are accounted for when selecting label sizes. An experimentally informed 3D continuum nanofluidic−nanoelectronic device model subsequently predicts both the ionic current and FET signals. We present a barcode design for a conceptually generic NP-FET, with a 14 nm diameter pore, operating in conditions corresponding to experiments. By adjusting the spacing between the labels to half the length of the pore, we show that a bit-rate of 78 kbit•s −1 is achievable. This lies well beyond the state-of-the-art of ≈40 kbit•s −1 , with significant headroom for further optimizations. We also highlight the advantages of NP-FET readout based on the larger signal size and sinusoidal signal shape.

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Side-gated ultrathin-channel nanopore FET sensors

Cited by 7 publications

References 54 publications

(Invited) BioFETs and Nanopore FETs: Nanoscale Silicon Field-Effect Transistors for Single-Molecule Sensing

(Invited) BioFETs and Nanopore FETs: Nanoscale Silicon Field-Effect Transistors for Single-Molecule Sensing

VLSI Structures for DNA Sequencing—A Survey

Design Principles of DNA-Barcodes for Nanopore-FET Readout, Based on Molecular Dynamics and TCAD Simulations

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