Side of Dental Anomalies and Taurodontism as Potential Clinical Markers for Cleft Subphenotypes

Küchler, Érika Calvano; Motta, Luise Gomes da; Vieira, Alexandre R.; Granjeiro, José Mauro

doi:10.1597/09-159

Cited by 73 publications

(82 citation statements)

References 34 publications

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“…We can perhaps even consider the isolated presence of dental agenesis or of supplemental/supernumerary teeth to be a rudimentary form of cleft, and consequently consider these dental anomalies to be destabilizing factors putting these patients at risk 8 . In this context, it might be important to study panoramic views of the ascendants and descendants of patients with a cleft in order to confirm the role of heredity, of genetic versus environmental factors in the appearance of these malformations.…”

Section: -Conclusionmentioning

confidence: 99%

Congenitally missing teeth and labio-palatal clefts: keep to the left

Matern¹,

Sauleau²,

Tschill³

et al. 2012

J Dentofacial Anom Orthod

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Section: -Conclusionmentioning

confidence: 99%

Congenitally missing teeth and labio-palatal clefts: keep to the left

Matern¹,

Sauleau²,

Tschill³

et al. 2012

J Dentofacial Anom Orthod

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“…The sexual dimorphism is explained by different effects of the human X and Y chromosome genes on various somatic features, such as the frequency of some dental anomalies and the tooth crown size [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

Sexual dimorphism involved in the mesiodistal and buccolingual dimensions of permanent teeth

Sabóia¹,

Tannure

Luiz

et al. 2013

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Studies indicate that tooth crown diameters are clinical markers for sex differentiation. Therefore, the aim of this study was to assess the degree of sexual dimorphism in different teeth. Maximum mesiodistal (MD) and buccolingual (BL) dimensions of 2400 permanent teeth from 100 pretreatment orthodontic dental study casts and clinical records (50 males and 50 females) from the Department of Pediatric Dentistry and Orthodontics, Federal University of Rio de Janeiro, Brazil, were examined. Comparison of the MD and BL dimensions between males and females was performed using the Student's t test with alpha 0.05, effect size, and discriminant function analysis. Comparisons in MD and BL widths between sexes demonstrated that the combined mean in the female group presented reduction when compared with the male group, except for the BL dimension of tooth 26. In regard to the MD dimensions, statistically significant differences were observed in various dental groups. The greatest sexual dimorphism was observed in the left mandibular canine (p<0.001) with effect size over 0.8 (0.94), which characterizes large effect. In BL dimension, numerous teeth demonstrated statistical differences between the sexes. Our findings reinforced the magnitude of sexual dimorphism in tooth size, and, in addition, highlighted the differences in specific dental groups.

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“…Some studies found no significant differences (Woolf et al 1965;Mills et al 1968;Anderson and Moss 1996;Haria et al 2000), concluding that unaffected relatives have no elevated risk of dental anomalies, which are also common in the general population (28%−40%) (Haugland et al 2013). Others instead have reported significant increases in agenesis, asymmetric dental development, microdontia, and supernumerary teeth (Schroeder and Green 1975;Eerens et al 2001;Kuchler et al 2011;Aspinall et al 2014).…”

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confidence: 99%

Spectrum of Dental Phenotypes in Nonsyndromic Orofacial Clefting

et al. 2015

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Children with oral clefts show a wide range of dental anomalies, adding complexity to understanding the phenotypic spectrum of orofacial clefting. The evidence is mixed, however, on whether the prevalence of dental anomalies is elevated in unaffected relatives and is mostly based on small samples. In the largest international cohort to date of children with nonsyndromic clefts, their relatives, and controls, this study characterizes the spectrum of cleft-related dental anomalies and evaluates whether families with clefting have a significantly higher risk for such anomalies compared with the general population. A total of 3,811 individuals were included: 660 cases with clefts, 1,922 unaffected relatives, and 1,229 controls. Dental anomalies were identified from in-person dental exams or intraoral photographs, and case-control differences were tested using χ2 statistics. Cases had higher rates of dental anomalies in the maxillary arch than did controls for primary (21% vs. 4%, P = 3 × 10−8) and permanent dentitions (51% vs. 8%, P = 4 × 10−62) but not in the mandible. Dental anomalies were more prevalent in cleft lip with cleft palate than other cleft types. More anomalies were seen in the ipsilateral side of the cleft. Agenesis and tooth displacements were the most common dental anomalies found in case probands for primary and permanent dentitions. Compared with controls, unaffected siblings (10% vs. 2%, P = 0.003) and parents (13% vs. 7%, P = 0.001) showed a trend for increased anomalies of the maxillary permanent dentition. Yet, these differences were nonsignificant after multiple-testing correction, suggesting genetic heterogeneity in some families carrying susceptibility to both overt clefts and dental anomalies. Collectively, the findings suggest that most affected families do not have higher genetic risk for dental anomalies than the general population and that the higher prevalence of anomalies in cases is primarily a physical consequence of the cleft and surgical interventions.

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Side of Dental Anomalies and Taurodontism as Potential Clinical Markers for Cleft Subphenotypes

Abstract: The preferential associations between specific cleft types with dental phenotypes suggest dental anomalies can be used as clinical markers to define the subphenotype isolated cleft lip and palate.

Cited by 73 publications

References 34 publications

Congenitally missing teeth and labio-palatal clefts: keep to the left

Congenitally missing teeth and labio-palatal clefts: keep to the left

Sexual dimorphism involved in the mesiodistal and buccolingual dimensions of permanent teeth

Spectrum of Dental Phenotypes in Nonsyndromic Orofacial Clefting

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