Siegfried Edlbacher 1886–1946

Dihydrogenated Alkaloids of Ergot in the Investigation and Treatment of Diastolic Hypertension

“…Nasal congestion, as mentioned, was considered to be a sign of stellate ganglion block, and was the commonest side-effect, occurring in 12 out of 17 subjects; it was noted by Bluntschli and Goetz (1947) and repeatedly since then by other authors. The slowing of heart rate as noted by Rothlin (1944) was shown to be partly inhibited by atropine by Wilkins et al (1949). This slowing may be due to the property possessed by ergot alkaloids of inactivating cholinesterase; it is possible that it is due to central nervous depression.…”

La thérapeutique de I'accès migraineux

“…Ce corps, obtenu en 1943 par Stoll et Hoffman (32), a été soumis a une étude pharmacologique approfondie par Rothlin et ses collaborateurs (33). Il a une action sympathoadrénolytique nettement plus puissante que celle de l'ergotamine.…”

IN VITRO STUDIES OF THE MOTILITY OF THE HUMAN UTERUS

“…These findings are in conformity with the results of Garrett (1955). On the other hand Rothlin and Berde (1954), in a study of the in vitro effects of ergot alkaloids o n the lower segment of the human pregnant uterus at term, claim that there is no qualitative difference between methylergometrine and dihydroergotamine, although the oxytocic effect of dihydroergotamine is much less pronounced than that of methylergometrine. Their results are definitely opposed to those of the present investigation.…”