Sigmoidoscopy and cytology in the detection of microscopic disease of the rectal mucosa in ulcerative colitis

Magnifying colonoscopy used to predict disease relapse in patients with quiescent ulcerative colitis

“…Even if clinical symptoms such as abdominal pain, diarrhea, and bloody stool disappear, endoscopic findings that represent the active phase of UC, such as redness, erosion, easy contact bleeding, and disappearance of vascularity may still remain. 20,21 Some studies have reported that microscopic evidence of inflammation is common even in patients with clinically and endoscopically quiescent UC, 22,23 and that the clinical and laboratory indices are relatively inaccurate means of assessing disease severity at the tissue level. 24 Another study reported that microscopic findings can be used as prognostic indicators without recourse to detailed morphometric analysis.…”

Phospholipase A₂ Activity of Colonic Mucosa in Patients with Ulcerative Colitis

“…Grade 2 was not interpreted as a sign of active colitis, since it has been found in about one third of patients with a normal macroscopic mucosa and no history of colitis [27], Phospholipase A? Analysis.…”

“…Histology sections stained with hematoxylin and cosin were blindly assessed for degree of inflammation by the pathologist (LF). We used a four-grade scale originally described by Watts et al [27] and slightly modified by us. Grade I: nor mal appearance with intact epithelium, small num bers of lymphocytes, plasma cells and macrophages in the lamina propria: grade 2: intact epithelium but increased numbers of chronic inflammatory cells in the lamina propria, occasional foci of polymorphonu clear leucocytes; grade 3: mild epithelial changes, leu kocytes within the epithelium or the crypts and ducts, pronounced inflammatory cellular infiltration in the lamina propria, and grade 4: severe inflammatory changes with evidence of crypt abscesses with de struction, inflammatory erosions or frank ulcer ation.…”

Magnifying chromoscopy, a novel and useful technique for colonoscopy in ulcerative colitis

“…Histopathologic assessment of UC Severity in ulcerative colitis is generally assessed using symptoms, laboratory data [17] , colonoscopic findings [2,[18][19][20][21][22][23][24][25] and the histologic degree of inflammation in the biopsy specimens [3,[26][27][28][29] . Of these, histopathologic assessment www.wjgnet.com is considered the standard for evaluation of disease activity [30] .…”

“…Observation under conventional colonoscopy is regarded as useful for the evaluation of disease activity, since it offers direct observation of mucosal changes, but it remains controversial whether colonoscopic grade correlates with histopathlogic findings. Notably, the degree of histologic inflammation within biopsy specimens does not necessarily correlate with endoscopic abnormalities [1,2,18,25,31] .…”