Signal Mechanism of the Protective Effect of Combined Preconditioning by Amtizole and Moderate Hypoxia

Левченкова, О. С.; Новиков, В. Е.; Abramova, E. S.; Feoktistova, Zh. A.

doi:10.1007/s10517-018-3981-5

Cited by 3 publications

(3 citation statements)

References 7 publications

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“…Currently, some of the NO donors (S-nitroso-Nacetyl-D, L-penicillamine; S-nitrosoglutathione) have been demonstrated to induce an increase in the HIF-1 activity [103]. This process is independent of cGMP, however, associated with activation of the redox-sensitive PI3K/AKT/ mTOR signaling pathway that controls the key cell functions [19].…”

Section: The Role Of Nitric Oxide and Mitochondrial Nitric Oxide Synthase In Cardioprotection During Hypoxia And Ischemia/reperfusionmentioning

confidence: 99%

Mitochondrial mechanisms by which gasotransmitters (H2S, NO and CO) protect cardiovascular system against hypoxia

Шемарова

Нестеров

Emelyanova

et al. 2021

Front. Biosci. (Schol Ed)

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Section: The Role Of Nitric Oxide and Mitochondrial Nitric Oxide Synthase In Cardioprotection During Hypoxia And Ischemia/reperfusionmentioning

confidence: 99%

Mitochondrial mechanisms by which gasotransmitters (H2S, NO and CO) protect cardiovascular system against hypoxia

Шемарова

Нестеров

Emelyanova

et al. 2021

Front. Biosci. (Schol Ed)

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“…Янтарная кислота, обеспечивая активность FАD-зависимого звена ДЦ и экспрессию HIF-1α, поддерживает метаболический и энергетический гомеостаз. Зависимые HIF-1 гены-мишени способствуют доставке кислорода через механизмы усиления транспорта глюкозы, продукции АТФ, ионного транспорта, клеточной пролиферации, активизации эритропоэза и ангиогенеза [20][21][22]26].…”

Section: таблица 2 / Table 2 изменение коэффициентов асимметрии попул...unclassified

Analyzing sensitivity of the energy metabolism in the tissues of the heart, liver, kidney, and blood lymphocytes in rats to the effect of local vibration and pharmacological protection by a succinate-containing antihypoxanth

Vorobyova¹,

Левченкова

Shabanov³

2021

Med. tr. prom. èkol.

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Introduction. Modern technological processes that generate ultra- and infrasound, electromagnetic, vibration-noise radiation significantly exceed the background effects and inevitably create an unfavorable technogenic load on the human body. A special place is occupied by vibration, primarily associated with such professional groups as mining enterprises, gold and diamond processing plants, aircraft plants, thermal power plants and hydroelectric power plants, and aluminum industry enterprises. Vibration exposure leads to a number of biochemical disorders in the homeostasis system. Mitochondrial dysfunctions are among the leading elements in the hierarchy of pathogenesis of many pathological syndromes and diseases. The aim of the study was an experimental analysis of tissue-specific features of the myocardium, kidneys, liver energy production system activity as well as the enzyme status of rat lymphocytes in relation to the activity of succinate dehydrogenase (SDH) on the background of 7 episodes of local vibration with a frequency of 27-30 Hz for 90 minutes daily before and after protection with succinate-containing antihypoxant "Yantar-cardio" at a dose of 100 mg/kg/day. Materials and methods. The study of the energy-dependent reactions of the native mitochondria of the organs was carried out by the polarographic method using a closed Clark-type membrane electrode. The activity of SDH of rat blood lymphocytes was studied by a modified method of quantitative cytochemical analysis. Results. Functional rearrangement in the respiratory chain (RC) of the mitochondria confirmed the NAD-dependent site's inhibition and activation of the oxidation system of endogenous succinic acid, most pronounced in the myocardial tissue. On the vibration background, the specific SDH activity of lymphocytes (Q) significantly increased by 52%, and the variability (V) - by three times. The use of "Yantar-cardio" limited the growth rate of endogenous respiration of the most significant in the heart (70%, p<0.05), restored oxidative and conjugating activity NAD-dependent link of RC, improve the structure and condition of the cell population of lymphocytes based on their energy status and warned the mismatch of the leading parameters of the population variability of the cellular pool of blood lymphocytes in experimental animals. Conclusions. The intensity of vibration-mediated bioenergetic hypoxia in the form of inhibition of the NAD-dependent link of the respiratory chain and activation of the endogenous succinic acid oxidation system is tissue-specific and is most pronounced in the myocardial tissue. The succinic acid oxidation system is highly sensitive to vibration effects and a pharmacological drug that supports the function of RC under conditions of the stress of the homeostatic functions of tissues involved in the pathological process.

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“…ст. ), что соответствовало высоте 5000 м (ГБГ-5000), экспозиция после достижения «высоты 5000 метров» составляла 60 мин [23].…”

Section: методы исследованияunclassified

Potentiation of the hypoxic preconditioning effect by antihypoxants

Новиков

Егорович²,

Левченкова

et al. 2019

Rev Clin Pharm Drug Ther

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The development of effective methods to increase the organism resistance to hypoxia is an important task of current medicine. One of such methods is preconditioning, as a result of which, a potent mobilization of the adaptive organism abilities occurs under a preconditioning factor action. Aim. To study the possibility of potentiating of the hypoxic preconditioning effect with help of antihypoxants. Methods. Evaluation of the effectiveness of combined preconditioning (antihypoxants + moderate hypobaric hypoxia) was performed on experimental models of acute hypoxia with hypercapnia, acute hypobaric hypoxia in mice, and bilateral occlusion of the common carotid arteries in rats. Investigated antihypoxants are amtizol, hypoxen, cobazole, metaprot, mexidol, mildronate, substances under the codes VM-606, pQ-4 and pQ-1104. Results. PreC with use of amtizol at dose 25 mg/kg, cobazole at dose 30 mg/kg, VM-606, pQ-4 and pQ-1104 at doses 50 mg/kg in combination with moderate hypoxia increased the lifespan of mice in acute hypoxia with hypercapniamodel and acute hypobaric hypoxia from 57 to 170%. Combined preconditioning with amtizol, cobazole and pQ-4 significantly increased the survival rate of rats in cerebral ischemia, amtizol and pQ-4 reduced neurological deficiency in the post ischemic period as well. Conclusion. Antitipoxants as amtizol, cobazole, VM-606, pQ-4, pQ-1104 potentiate the hypoxic preconditioning effect on acute hypoxia with hypercapnia, acute hypobaric hypoxia and occlusion of the common carotid arteries models, the most significant effect was noted for amtizol and pQ-4. Signal role in the adaptation induction to hypoxia and ischemia by combined preconditioning with use of antihypoxants hypoxia-inducible factor HIF-1α can play.

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Signal Mechanism of the Protective Effect of Combined Preconditioning by Amtizole and Moderate Hypoxia

Cited by 3 publications

References 7 publications

Mitochondrial mechanisms by which gasotransmitters (H2S, NO and CO) protect cardiovascular system against hypoxia

Mitochondrial mechanisms by which gasotransmitters (H2S, NO and CO) protect cardiovascular system against hypoxia

Analyzing sensitivity of the energy metabolism in the tissues of the heart, liver, kidney, and blood lymphocytes in rats to the effect of local vibration and pharmacological protection by a succinate-containing antihypoxanth

Potentiation of the hypoxic preconditioning effect by antihypoxants

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