Signal transducer and activator of transcription (STAT)-5: an opportunity for drug development in oncohematology

Recio, Carlota; Guerra, Borja; Guerra-Rodríguez, Miguel; Aranda-Tavío, Haidée; Martín-Rodríguez, Patricia; Mirecki-Garrido, Mercedes de; Brito‐Casillas, Yeray; García-Castellano, José Manuel; Estévez‐Braun, Ana; Fernández-Pérez, Leandro

doi:10.1038/s41388-019-0752-3

Cited by 31 publications

(18 citation statements)

References 83 publications

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“…The deregulation of the JAK-STAT pathway was noted to be involved in cancer development. STAT proteins are phosphorylated and consequently move into the nucleus to transcriptionally upregulate target genes [21][22][23]. SOCS (suppressor of cytokine signaling) and PIAS (protein inhibitors of activated STATs) are negative regulators of STAT-driven signaling [24].…”

Section: Regulation Of Jak-stat Signalingmentioning

confidence: 99%

The Prowess of Andrographolide as a Natural Weapon in the War against Cancer

Farooqı

Attar

Sabitaliyevich

et al. 2020

Cancers

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There has been a paradigm shift in our understanding about the multifaceted nature of cancer and a wealth of information has revealed that single-target drugs are not good enough to provide satisfactory clinical outcomes and therapeutic effects for complex diseases which involve multiple factors. Therefore, there has been a reignition to search for natural products having premium pharmacological activities aim to efficiently target multiple deregulated cellular signaling pathways. Andrographolide, a diterpene lactone from Andrographis paniculata was brought into to the limelight because of its ability to inhibit cancer cell proliferation and induce apoptosis. Here we review andrographolide on cellular pathways regulation including Wnt/β-catenin, mTOR, VEGF-mediated intracellular signaling, as well as TRAIL-mediated apoptosis to inhibit cancer development.

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Section: Regulation Of Jak-stat Signalingmentioning

confidence: 99%

The Prowess of Andrographolide as a Natural Weapon in the War against Cancer

Farooqı

Attar

Sabitaliyevich

et al. 2020

Cancers

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“…For an optimal cell cycle progression and cell proliferation, TRIM proteins act on crucial factors like p53 and/or on important pathways, including JAK/STAT signaling. The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is a highly conserved cellular cascade which connects the extracellular signaling from growth factors and cytokines with the nuclear transcriptional machinery [36]. Cytokine-induced activation of the JAK/STAT3 pathway leads to JAK2 recruitment and STAT3 phosphorylation and dimerization.…”

Section: Trims and Cell Cycle Progressionmentioning

confidence: 99%

E3 Ubiquitin Ligase TRIM Proteins, Cell Cycle and Mitosis

Venuto

Merla

2019

Cells

116

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The cell cycle is a series of events by which cellular components are accurately segregated into daughter cells, principally controlled by the oscillating activities of cyclin-dependent kinases (CDKs) and their co-activators. In eukaryotes, DNA replication is confined to a discrete synthesis phase while chromosome segregation occurs during mitosis. During mitosis, the chromosomes are pulled into each of the two daughter cells by the coordination of spindle microtubules, kinetochores, centromeres, and chromatin. These four functional units tie chromosomes to the microtubules, send signals to the cells when the attachment is completed and the division can proceed, and withstand the force generated by pulling the chromosomes to either daughter cell. Protein ubiquitination is a post-translational modification that plays a central role in cellular homeostasis. E3 ubiquitin ligases mediate the transfer of ubiquitin to substrate proteins determining their fate. One of the largest subfamilies of E3 ubiquitin ligases is the family of the tripartite motif (TRIM) proteins, whose dysregulation is associated with a variety of cellular processes and directly involved in human diseases and cancer. In this review we summarize the current knowledge and emerging concepts about TRIMs and their contribution to the correct regulation of cell cycle, describing how TRIMs control the cell cycle transition phases and their involvement in the different functional units of the mitotic process, along with implications in cancer progression.

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“…The JAK/STAT pathway is a crucial signaling pathway that is abnormally activated in OC, and its constitutive activation is strongly related to tumor progression and poor prognosis for the disease [ 34 ]. Hyperstimulation of this pathway has also been found in other cancers, including breast, gastric, lung, prostate, and hematopoietic malignancies [ 35 , 36 , 37 ]. JAK/STAT pathway-mediated tumor progression is mainly due to the expression of a variety of proteins and cytokines involved in cellular proliferation, stemness and self-renewal, survival, and evasion of antitumor immunity [ 37 , 38 ].…”

Section: Targeting Numerous Signaling Pathways Of Ovarian Cancermentioning

confidence: 99%

Recent Advances in Ovarian Cancer: Therapeutic Strategies, Potential Biomarkers, and Technological Improvements

Akter

Rahman

Hasan³

et al. 2022

Cells

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Aggressive and recurrent gynecological cancers are associated with worse prognosis and a lack of effective therapeutic response. Ovarian cancer (OC) patients are often diagnosed in advanced stages, when drug resistance, angiogenesis, relapse, and metastasis impact survival outcomes. Currently, surgical debulking, radiotherapy, and/or chemotherapy remain the mainstream treatment modalities; however, patients suffer unwanted side effects and drug resistance in the absence of targeted therapies. Hence, it is urgent to decipher the complex disease biology and identify potential biomarkers, which could greatly contribute to making an early diagnosis or predicting the response to specific therapies. This review aims to critically discuss the current therapeutic strategies for OC, novel drug-delivery systems, and potential biomarkers in the context of genetics and molecular research. It emphasizes how the understanding of disease biology is related to the advancement of technology, enabling the exploration of novel biomarkers that may be able to provide more accurate diagnosis and prognosis, which would effectively translate into targeted therapies, ultimately improving patients’ overall survival and quality of life.

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Signal transducer and activator of transcription (STAT)-5: an opportunity for drug development in oncohematology

Cited by 31 publications

References 83 publications

The Prowess of Andrographolide as a Natural Weapon in the War against Cancer

The Prowess of Andrographolide as a Natural Weapon in the War against Cancer

E3 Ubiquitin Ligase TRIM Proteins, Cell Cycle and Mitosis

Recent Advances in Ovarian Cancer: Therapeutic Strategies, Potential Biomarkers, and Technological Improvements

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