Signal transduction in multifactorial neuroendocrine control of gonadotropin secretion and synthesis in teleosts—studies on the goldfish model

Chang, John P.; Johnson, James D.; Sawisky, Grant R.; Grey, Caleb L.; Mitchell, Gabriel; Booth, Morgan; Volk, Mark M.; Parks, Scott K.; Thompson, Erin; Goss, Greg G.; Klausen, Christian; Habibi, Hamid R.

doi:10.1016/j.ygcen.2008.09.005

Cited by 84 publications

(52 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In goldfish, mRNA for both sGnRH and cGnRH-II are present in the pituitary and both GnRHs are released from nerve terminals invading the pars distalis [47,48] and GnRH is a major neuroendocrine factor of LH release, as well as an effective stimulator of GH secretion [7][8][9]. In addition, goldfish pituitary glands express Kiss1 mRNA [46].…”

Section: Discussionmentioning

confidence: 99%

“…Likewise, the presence of Kiss immunoreactivity and/or mRNA in the pituitary has also been reported for other teleosts, including zebrafish and grass puffer [37,38], suggesting direct pituitary actions of Kiss may be present in other teleosts. Incubation of dispersed goldfish pituitary cells with synthetic goldfish Kiss1 (1)(2)(3)(4)(5)(6)(7)(8)(9)(10) (gKiss1 10 ) increased LH and GH released into culture medium by 30 min, as well as elevated LH and GH mRNA levels by 24 h [46]. In contrast, another study indicates that while injection of gKiss1 10 , but not gKiss2 10 , increased serum LH in sexually mature female goldfish, both peptides were ineffective in in vitro 0.5 and 3 h static incubation experiments with goldfish pituitary cells suggesting that gKiss1 did not directly affect pituitary LH secretion [19].…”

Section: Introductionmentioning

confidence: 99%

“…We also examined the interactions of gKiss1 10 with the two native goldfish GnRHs, salmon (s)GnRH (goldfish GnRH-3) and chicken (c)GnRH-II (goldfish GnRH-2) [48,49], on LH and GH release; these two GnRHs have been shown to be physiological neuroendocrine stimulators of both LH and GH secretion in this system [4,8,9]. Since Ca 2+ signalling and Ca 2+ entry through voltage-sensitive Ca 2+ channels (VSCCs) are important intracellular events in the neuroendocrine regulation of LH and GH release in goldfish [4,[7][8][9], and Ca 2+ mediates the actions of Kiss1 in many mammalian target tissues [23,28], we also tested the hypothesis that the hormone-releasing effects of gKiss1 10 are dependent on Ca 2+ entry via VSCCs.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Kisspeptin-1 directly stimulates LH and GH secretion from goldfish pituitary cells in a Ca2+-dependent manner

Chang¹,

Már²,

Wlasichuk³

et al. 2012

General and Comparative Endocrinology

Self Cite

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Kisspeptin-1 directly stimulates LH and GH secretion from goldfish pituitary cells in a Ca2+-dependent manner

Chang¹,

Már²,

Wlasichuk³

et al. 2012

General and Comparative Endocrinology

Self Cite

View full text Add to dashboard Cite

“…As MAPKs são rapidamente ativadas nos gonadotrofos de gold fish, quando existe o estímulo do GnRH (Yu et al, 2007). Quando inibidas ocorre à diminuição da expressão do LH, sugerindo um papel importante na sinalização destas enzimas no controle neuroendócrino e síntese de gonadotrofinas (Chang et al, 2009). Porém o papel destas na transcrição basal e estimulação da subunidade β inespecífica é controverso.…”

Section: Hormômio Liberador De Gonadotrofinas (Gnrh)unclassified

Visão geral sobre reprodução de peixes teleósteos: da anatomia à sinalização molecular

Souto

Faria

Oliveira

et al. 2017

Pubvet

View full text Add to dashboard Cite

RESUMO.Um dos principais objetivos da na reprodução e peixes é a produção de um grande número de gametas viáveis e alta sobrevivência da prole. Nos últimos anos, foram realizados importantes progressos na melhoria da eficiência na produção de gametas e viabilidade da prole. No entanto, existem lacunas importantes no que diz respeito à compreensão dos processos dinâmicos fisiológicos associados à gametogênese. O conhecimento das estruturas que compõe as gônadas, bem como o todos os mecanismos neuroendócrinos e de sinalização molecular é de extrema importância na elaboração de protocolos reprodutivos de peixes. Entre os desafios encontrados, destaca-se a ampla gama de espécies de peixes de diferentes famílias, os quais, na maioria das vezes, possuem mecanismos fisiológicos espécie-específico. No mecanismo neuroendócrino da reprodução de peixes é dado ênfase ao Hormônio liberador de gonadotrofinas (GnRH), neurotransmissor produzido e secretado pelo hipotálamo, que atua como fator estimulador na liberação de LH e, em menor grau, do FSH. Os hormônios gonadotróficos folículo estimulante e luteinizante (FSH e LH) atuam como os principais reguladores durante a vitelogênese e maturação dos gametas. Acreditava-se que a melatonina estaria envolvida no mecanismo neuroendócrino como resposta ao foto-período, inibindo a liberação de GnRH. Recentemente, estudos evidenciaram que a melatonina atua também acelerando a ação do hormônio indutor da maturação (MIH) e, consequentemente, a retomada do ciclo celular meiótico. Desta forma, o objetivo desta revisão é esclarecer os mecanismos fisiológicos da reprodução de peixes teleósteos, partindo da descrição da morfologia das gônadas, compreensão dos mecanismos neuroendócrinos e da sinalização molecular.Palavras chave: Gametogênese, hormônio indutor de maturação, melatonina, sinalização molecular Overview on reproduction of teleosteal fish: from anatomy to molecular signaling ABSTRACT. One of the main goals of reproduction and fish is the production of a large number of viable gametes and high survival of offspring. In recent years, significant progress has been made in improving the efficiency of gametes production and progeny viability. However, there are still important gaps in the understanding of the physiological dynamic processes associated with gametogenesis. The knowledge of the structures that make up the gonads, as well as the all the neuroendocrine and molecular signaling

show abstract

“…See Table 2 for gene abbreviation key. [73]. Tenascin-R is involved in regenerating optic axons in zebrafish [74], and its expression has been shown to increase with testosterone in zebra finches [75].…”

Section: Mapping the Transcriptional Response To Flutamide Exposurementioning

confidence: 99%

Reverse engineering adverse outcome pathways

Perkins

Chipman

Edwards

et al. 2011

Environmental Toxicology and Chemistry

View full text Add to dashboard Cite

The toxicological effects of many stressors are mediated through unknown, or incompletely characterized, mechanisms of action. The application of reverse engineering complex interaction networks from high dimensional omics data (gene, protein, metabolic, signaling) can be used to overcome these limitations. This approach was used to characterize adverse outcome pathways (AOPs) for chemicals that disrupt the hypothalamus-pituitary-gonadal endocrine axis in fathead minnows (FHM, Pimephales promelas). Gene expression changes in FHM ovaries in response to seven different chemicals, over different times, doses, and in vivo versus in vitro conditions, were captured in a large data set of 868 arrays. Potential AOPs of the antiandrogen flutamide were examined using two mutual information-based methods to infer gene regulatory networks and potential AOPs. Representative networks from these studies were used to predict network paths from stressor to adverse outcome as candidate AOPs. The relationship of individual chemicals to an adverse outcome can be determined by following perturbations through the network in response to chemical treatment, thus leading to the nodes associated with the adverse outcome. Identification of candidate pathways allows for formation of testable hypotheses about key biological processes, biomarkers, or alternative endpoints that can be used to monitor an AOP. Finally, the unique challenges facing the application of this approach in ecotoxicology were identified and a road map for the utilization of these tools presented.

show abstract

Signal transduction in multifactorial neuroendocrine control of gonadotropin secretion and synthesis in teleosts—studies on the goldfish model

Cited by 84 publications

References 73 publications

Kisspeptin-1 directly stimulates LH and GH secretion from goldfish pituitary cells in a Ca2+-dependent manner

Kisspeptin-1 directly stimulates LH and GH secretion from goldfish pituitary cells in a Ca2+-dependent manner

Visão geral sobre reprodução de peixes teleósteos: da anatomia à sinalização molecular

Reverse engineering adverse outcome pathways

Contact Info

Product

Resources

About