Signal Transduction Mediated through Adhesion-GPCRs

Mizuno, Norikazu; Itoh, Hiroshi

doi:10.1007/978-1-4419-7913-1_14

Cited by 9 publications

(12 citation statements)

References 52 publications

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“…In addition, the complicated structure of Adhesion GPCRs, comprising both largely ECD and 7TM domains, make it possible for Adhesion GPCRs to go through the signaling pathway in a G-protein-independent manner [83] . For example, Gpr124 regulates angiogenic sprouting into neural tissues through TGF-beta pathway in mouse [76] .…”

Section: Signal Transduction Mediated By Adhesion Gpcrsmentioning

confidence: 99%

Orphan G protein-coupled receptors (GPCRs): biological functions and potential drug targets

et al. 2012

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The superfamily of G protein-coupled receptors (GPCRs) includes at least 800 seven-transmembrane receptors that participate in diverse physiological and pathological functions. GPCRs are the most successful targets of modern medicine, and approximately 36% of marketed pharmaceuticals target human GPCRs. However, the endogenous ligands of more than 140 GPCRs remain unidentified, leaving the natural functions of those GPCRs in doubt. These are the so-called orphan GPCRs, a great source of drug targets. This review focuses on the signaling transduction pathways of the Adhesion GPCR family, the LGR subfamily, and the PSGR subfamily, and their potential functions in immunology, development, and cancers. In this review, we present the current approaches and difficulties of orphan GPCR deorphanization and characterization.

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Section: Signal Transduction Mediated By Adhesion Gpcrsmentioning

confidence: 99%

Orphan G protein-coupled receptors (GPCRs): biological functions and potential drug targets

et al. 2012

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“…A major issue hindering functional research is the lack of knowledge concerning their receptor signalling, mainly because of the complicated receptor structure and the lack of optimal assay systems. To date, it is still not known whether F4/80 is coupled to G proteins; although other adhesion-GPCRs, such as GPR56 and latrophilin, have been shown to associate with G a12/13 and G aq proteins, respectively [32].…”

Section: Functionmentioning

confidence: 99%

F4/80 and the related adhesion‐GPCRs

et al. 2011

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The F4/80 monoclonal antibody was first reported in this journal 30 years ago (Eur. J. Immunol. 1981. 11: 805–815). F4/80 has become a widely used marker for monocytes and many, but not all, tissue macrophages in the mouse. F4/80 is a member of the EGF‐TM7 family of leukocyte plasma membrane heptahelical molecules, which includes CD97 and EMR2. This Viewpoint summarises current knowledge of the expression, structure and functions of the EGF‐TM7 family, as part of a larger family of tissue adhesion‐GPCRs.

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“…This otherwise highly heterogenic GPCR subfamily shares an extended N-terminal domain, often comprising domains characteristic for adhesion molecules linked to the 7TM stretches by a GPCR proteolytic site (16,17). The vast majority of adhesion GPCRs are still orphan receptors, and evidence that they exhibit classical signaling has only recently been provided (18,19). In contrast to fairly well characterized adhesion GPCRs such as the EGF-7TM receptors (20), the only hint for the function of others is their tissue distribution reflected by microarray and expressed sequence tag data.…”

mentioning

confidence: 99%

The Orphan Adhesion G Protein-coupled Receptor GPR97 Regulates Migration of Lymphatic Endothelial Cells via the Small GTPases RhoA and Cdc42

Valtcheva

Primorac

Jurisic³

et al. 2013

Journal of Biological Chemistry

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Background:The identification of G protein-coupled receptors (GPCRs) specific for the lymphatic endothelial cells (LECs) is essential for establishing drugs targeting the lymphatic system. Results: GPR97 is an orphan adhesion GPCR that regulates LEC migration. Conclusion: GPR97 is the first known adhesion GPCR involved in lymphatic remodeling. Significance: This first evidence that adhesion GPCRs govern LEC motility opens new possibilities for modulating lymphangiogenesis.

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Signal Transduction Mediated through Adhesion-GPCRs

Cited by 9 publications

References 52 publications

Orphan G protein-coupled receptors (GPCRs): biological functions and potential drug targets

Orphan G protein-coupled receptors (GPCRs): biological functions and potential drug targets

F4/80 and the related adhesion‐GPCRs

The Orphan Adhesion G Protein-coupled Receptor GPR97 Regulates Migration of Lymphatic Endothelial Cells via the Small GTPases RhoA and Cdc42

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