Signal transduction pathways involved in low intensity He–Ne laser‐induced respiratory burst in bovine neutrophils: A potential mechanism of low intensity laser biostimulation

Duan, Rui; Liu, Timon Cheng Yi; Li, Yan; Guo, Hong; Yao, Li

doi:10.1002/lsm.1106

Cited by 54 publications

(33 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For example, LEVL increases the rate of wound healing (3), enhances the fertilizing capability of sperm cells (4), and increases the rate of healing bone defects (5). In vitro studies have found that LEVL increases proliferation of cells as fibroblasts (6), keratinocytes (7), and lymphocytes (8) and induces the respiratory burst in neutrophils (9). The mechanism of photobiostimulation by LEVL is still unclear.…”

mentioning

confidence: 99%

Low Energy Visible Light Induces Reactive Oxygen Species Generation and Stimulates an Increase of Intracellular Calcium Concentration in Cardiac Cells

Lavi

Shainberg

Friedmann

et al. 2003

Journal of Biological Chemistry

168

View full text Add to dashboard Cite

Low energy visible light (LEVL) irradiation has beenshown to exert some beneficial effects on various cell cultures. For example, it increases the fertilizing capability of sperm cells, promotes cell proliferation, induces sprouting of neurons, and more. To learn about the mechanism of photobiostimulation, we studied the relationship between increased intracellular calcium ( Life on earth is entirely dependent upon the interaction of sunlight with cells especially in plant photosynthesis (1). Sunlight also has medical benefits, which have been exploited for over thousands of years in ancient Egypt, India, and China in treating skin diseases, psoriasis, vitiligo, and even cancer (2). Recent observations show that even low energy visible light (LEVL) 1 can serve as a medical tool. For example, LEVL increases the rate of wound healing (3), enhances the fertilizing capability of sperm cells (4), and increases the rate of healing bone defects (5). In vitro studies have found that LEVL increases proliferation of cells as fibroblasts (6), keratinocytes (7), and lymphocytes (8) and induces the respiratory burst in neutrophils (9). The mechanism of photobiostimulation by LEVL is still unclear. It has been suggested that reactive oxygen species (ROS), which can be produced by photosensitization of endogenous cell chromophores such as cytochromes (10) [Ca 2ϩ ] i followed by myosin phosphorylation and cell contractions (26). Growth factors and hormones were shown to stimulate ROS production, which were dependent on [Ca 2ϩ ] i rise (27). The relationship between ROS and [Ca 2ϩ ] i has been suggested to involve the redox-sensitive transcription factor N␤, which was found to change [Ca 2ϩ ] i homeostasis in response to changes in the redox state of thiol groups (28). The kinetics that characterize the [Ca 2ϩ ] i elevation have been shown to be an important parameter determining the kind of signal that will be evoked. Livingston et al. (29) showed that high concentrations of oxidants (Ͼ50 M) caused a sustained increase in [Ca 2ϩ ] i , whereas a transient increase in [Ca 2ϩ ] i was observed following administration of a low concentration of oxidants. More than a 4-fold increase in the [Ca 2ϩ ] i level was obtained in photodynamic treatment of mouse myeloma cells that had been enriched with exogenous photosensitizers before illumination, whereas only a slight increase in [Ca 2ϩ ] i was observed in irradiated cells without exogenous photosensitizers (30).Only a few works have dealt with calcium/ROS changes following LEVL irradiation. In this study, we have investigated * The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.§ The article describes research performed by Ronit Lavi as partial fulfillment of the requirements for her Ph.D. degree at Bar-Ilan University. To whom correspondence should be addressed. Tel.: 972-3-5317797; Fax: 972-3-...

show abstract

mentioning

confidence: 99%

Low Energy Visible Light Induces Reactive Oxygen Species Generation and Stimulates an Increase of Intracellular Calcium Concentration in Cardiac Cells

Lavi

Shainberg

Friedmann

et al. 2003

Journal of Biological Chemistry

168

View full text Add to dashboard Cite

show abstract

“…Thus, CINN did not directly attenuate the MPO pathway. In previous studies, calphostin C, an inhibitor of protein kinase C (PKC) can obviously reduce the He-Ne laser-induced respiratory burst of neutrophils [32], and the PMA is a stimulator for PKC-mediated NADPH oxidase and nitric oxide (NO) synthase during respiratory burst of neutrophils [33]. Therefore, it was very possible that CINN could also be a PKC inhibitor, It should be emphasized that fluorescent dyes such as DHR (for H 2 O 2 ) and DHE (for superoxide radical) is not the best method of choice for radical detection, although it is more preferable in the cellular-based studies.…”

Section: Discussionmentioning

confidence: 99%

Cinnamophilin Inhibits Neutrophilic Respiratory Burst and Protects Against Ischemia-Reperfusion Brain Damage

Tien¹

2013

Pharm Anal Acta

View full text Add to dashboard Cite

“…TPKR affect also cell proliferation by the Phosphatidylinositide 3-kinases (PI3K)/Protein kinases B (Akt) pathway and Phospolipase C gamma (PLC-gamma)/Protein kinases C (PKC) pathway [7]. ROS produced as a cellular response to irradiation of LLLT, activates Src tyrosine kinase [8], which is responsible for increased proliferation of many kinds of cell cultures.…”

Section: Modification Of Kinases Activitymentioning

confidence: 99%

The Use of Low-Level Energy Laser Radiation in Basic and Clinical Research

Rola¹,

Doroszko²,

Derkacz³

2014

Adv Clin Exp Med

View full text Add to dashboard Cite

Laser radiation has specific attributes: monochromaticity, high coherence and polarization. These properties result in the extensive use of lasers in medicine. Laser devices can be assigned into three basic groups by means of their level of energy: high, medium and low energy. All of these types of radiation are used in medicine. However, the most commonly used, in basic science and clinical studies, is low-energy radiation. Molecular effects of low energy laser irradiation on cells are generally described as "fotobiostimulation" and "fotobiomodulation". These phenomena consequently lead to attempts to exploit this kind of radiation as a treatment method (low-level laser therapy-LLLT). Areas in which LLLT is used are: regenerative medicine (for healing wounds and ulcers); aesthetic medicine (to improve appearance of scars); dentistry (to accelerate healing of implants); physiotherapy (to reduce chronic pain syndromes), orthopedics (in bone healing) and cardiology (as a prevention of restenosis after percutaneous coronary intervention). This paper discusses the medical applications of LLLT which are used in daily clinical practice as well as those The laser was invented by Theodor Maiman in 1960 and since that time it is used in many different aspects of human life, including medicine. Lasers are distinguished from other light sources by their coherence, polarization and monochromaticity; therefore, they can transmit a wide range of energy.The physical process enabling the laser to function is called stimulated emission (laser is an acronym of light amplification by stimulated emission of radiation). There are many ways to classify laser devices. Lasers can be grouped by gain medium, wavelengths, modes of operation but the most useful way, from a medical point of view, is the division by energy level. And so by the amount of energy transmitted, the sources of laser radiation are divided into 3 basic groups: low, medium and high energy.There are many reports regarding the usefulness of full laser energy spectrum in clinical practice. High-energy radiation causes tissue destruction and therefore it is mainly applied in surgery. It is used for coagulation, cutting tissue, control of bleeding, destruction of tumors etc. Medium energy lasers are mainly used in oncology, especially as a part of photodynamic therapy. The low energy laser, among the all energy radiation groups, seems to have the widest range of applications in medicine. Despite much research, the exact mechanism action of low energy laser radiation on the human body is still unknown. Due to numerous studies on low-energy radiation, new therapeutic applications are being discovered and enrolled to clinical practice. The aim of this paper is to review the most common clinical applications of low-energy lasers.

show abstract

Signal transduction pathways involved in low intensity He–Ne laser‐induced respiratory burst in bovine neutrophils: A potential mechanism of low intensity laser biostimulation

Abstract: These results suggest that PTKs play a key role in the He-Ne laser-induced respiratory burst of neutrophils and [PTK-PLC-PKC-NADPH oxidase] signal transduction pathways may be involved in this process.

Cited by 54 publications

References 23 publications

Low Energy Visible Light Induces Reactive Oxygen Species Generation and Stimulates an Increase of Intracellular Calcium Concentration in Cardiac Cells

Low Energy Visible Light Induces Reactive Oxygen Species Generation and Stimulates an Increase of Intracellular Calcium Concentration in Cardiac Cells

Cinnamophilin Inhibits Neutrophilic Respiratory Burst and Protects Against Ischemia-Reperfusion Brain Damage

The Use of Low-Level Energy Laser Radiation in Basic and Clinical Research

Contact Info

Product

Resources

About