SUMMARYTo assess safety impacts of untried traffic control strategies, an earlier study developed a vehicle dynamics model-integrated (i.e., VISSIM-CarSim-SSAM) simulation approach and evaluated its performance using surrogate safety measures. Although the study found that the integrated simulation approach was a superior alternative to existing approaches in assessing surrogate safety, the computation time required for the implementation of the integrated simulation approach prevents it from using it in practice. Thus, this study developed and evaluated two types of models that could replace the integrated simulation approach with much faster computation time, feasible for real-time implementation. The two models are as follows: (i) a statistical model (i.e., logit model) and (ii) a nonparametric approach (i.e., artificial neural network). The logit model and the neural network model were developed and trained on the basis of three simulation data sets obtained from the VISSIM-CarSim-SSAM integrated simulation approach, and their performances were compared in terms of the prediction accuracy. These two models were evaluated using six new simulation data sets. The results indicated that the neural network approach showing 97.7% prediction accuracy was superior to the logit model with 85.9% prediction accuracy. In addition, the correlation analysis results between the traffic conflicts obtained from the neural network approach and the actual traffic crash data collected in the field indicated a statistically significant relationship (i.e., 0.68 correlation coefficient) between them. This correlation strength is higher than that of the VISSIM only (i.e., the state of practice) simulation approach. The study results indicated that the neural network approach is not only a time-efficient way to implementing the VISSIM-CarSim-SSAM integrated simulation but also a superior alternative in assessing surrogate safety.