Signals Between Cells and Matrix Mediate Bone Regeneration

Zohar, Ron

doi:10.5772/38292

Cited by 7 publications

(7 citation statements)

References 142 publications

(157 reference statements)

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“…As previously discussed, bone matrix does not only provides support for bone cells, but also has a key role in regulating the activity of bone cells through several adhesion molecules [ 117 , 128 ]. Integrins are the most common adhesion molecules involved in the interaction between bone cells and bone matrix [ 129 ].…”

Section: Bone Cellsmentioning

confidence: 99%

Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells

Florencio‐Silva

Sasso

Sasso-Cerri

et al. 2015

BioMed Research International

1,419

970

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Bone tissue is continuously remodeled through the concerted actions of bone cells, which include bone resorption by osteoclasts and bone formation by osteoblasts, whereas osteocytes act as mechanosensors and orchestrators of the bone remodeling process. This process is under the control of local (e.g., growth factors and cytokines) and systemic (e.g., calcitonin and estrogens) factors that all together contribute for bone homeostasis. An imbalance between bone resorption and formation can result in bone diseases including osteoporosis. Recently, it has been recognized that, during bone remodeling, there are an intricate communication among bone cells. For instance, the coupling from bone resorption to bone formation is achieved by interaction between osteoclasts and osteoblasts. Moreover, osteocytes produce factors that influence osteoblast and osteoclast activities, whereas osteocyte apoptosis is followed by osteoclastic bone resorption. The increasing knowledge about the structure and functions of bone cells contributed to a better understanding of bone biology. It has been suggested that there is a complex communication between bone cells and other organs, indicating the dynamic nature of bone tissue. In this review, we discuss the current data about the structure and functions of bone cells and the factors that influence bone remodeling.

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Section: Bone Cellsmentioning

confidence: 99%

Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells

Florencio‐Silva

Sasso

Sasso-Cerri

et al. 2015

BioMed Research International

1,419

970

View full text Add to dashboard Cite

show abstract

“…Approximately 90% of the entire bone tissue consists of bone matrix which is chiefly composed of type I collagen fibers and noncollagenous proteins (Hadjidakis and Androulakis 2006). Bone matrix acts as a supporter and regulator for the activity of different bone cells; osteoblasts, osteocytes, osteoclasts and bone lining cells (Green, Schotland et al 1995;Zohar 2012).…”

Section: Introductionmentioning

confidence: 99%

Wnt signaling pathway as a regulator of bone formation and healing.

Elseweidy

Elswefy

Baraka

et al. 2021

Zagazig Journal of Pharmaceutical Sciences

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Bone is a mineralized structure that is mainly made of a matrix that supports the various types of bone cells; osteoblasts, osteoclasts, osteocytes and bone lining cells. Bone mass is preserved as a result of the balance between bone forming osteoblasts and bone resorbing osteoclasts, in a process known as bone remodeling. Bone remodeling process occurs mainly in three steps: resorption, reversal and formation. These steps are controlled locally and systemically by numerous regulatory factors. Among these regulatory factors, wingless-related MMTV integration site (Wnt) signaling pathway plays a significant role in maintainig bone mass as well as regulating many cellular processes. Based on whether β-catenin is involved or not, Wnt signaling is categorized into two main pathways; the canonical and the non-canonical pathways. The actions exerted by the Wnt signaling pathway are achieved when Wnt ligands bind to specific transmembrane receptors such as the Frizzled family (Frz) members and low density lipoprotein receptor-related proteins (LRPs) and are inhibited when these ligands or receptors bind to Wnt signaling inhibitors such as Wnt inhibitory factor 1 (WIF1), secreted Frizzledrelated proteins (sFRPs), Dickkopf 1 (DKK1) and sclerostin. Improper synthesis of any of these ligands, receptors or inhibitors leads to disruption of different body functions and progression of various diseases including skeletal diseases. Therefore, the components of the Wnt signaling pathway can be targeted for developing novel therapeutic agents to manage different diseases.

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“…Thus, optimal bone regenerative therapy should enhance mineralized tissue healing through enrichment of the bone defect with a micro/nanostructured matrix scaffold to support the wound, with cells that will give raise to osteoprogenitors and proper biochemical stimuli. Recently, a factor controlling the fate of many osteocompentent cells has been introduced, taking in consideration that micro- e nano-topography of the bone architectures could have a role in the regulation of the activity of the bone cells trough the activation of cellular mechanotransduction mechanisms mediated by adhesion molecules (Green et al, 1995; Zohar, 2012). In particular, this complex bone architecture resulted mainly sustained by collagen and hydroxyapatite (HA), which together form a highly aligned composite matrix that contribute to the toughness and strength of bone itself (Weiner et al, 1999; Kerschnitzki et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Nanotopography Induced Human Bone Marrow Mesangiogenic Progenitor Cells (MPCs) to Mesenchymal Stromal Cells (MSCs) Transition

Abednatanzi

Montali

Jacchetti

et al. 2016

Front. Cell Dev. Biol.

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Mesangiogenic progenitor cells (MPCs) are a very peculiar population of cells present in the human adult bone marrow, only recently discovered and characterized. Owing to their differentiation potential, MPCs can be considered progenitors for mesenchymal stromal cells (MSCs), and for this reason they potentially represent a promising cell population to apply for skeletal tissue regeneration applications. Here, we evaluate the effects of surface nanotopography on MPCs, considering the possibility that this specific physical stimulus alone can trigger MPC differentiation toward the mesenchymal lineage. In particular, we exploit nanogratings to deliver a mechanical, directional stimulus by contact interaction to promote cell morphological polarization and stretching. Following this interaction, we study the MPC-MSC transition by i. analyzing the change in cell morphotype by immunostaining of the key cell-adhesion structures and confocal fluorescence microscopy, and ii. quantifying the expression of cell-phenotype characterizing markers by flow cytometry. We demonstrate that the MPC mesengenic differentiation can be induced by the solely interaction with the NGs, in absence of any other external, chemical stimulus. This aspect is of particular interest in the case of multipotent progenitors as MPCs that, retaining both mesengenic and angiogenic potential, possess a high clinical appeal.

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Signals Between Cells and Matrix Mediate Bone Regeneration

Cited by 7 publications

References 142 publications

Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells

Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells

Wnt signaling pathway as a regulator of bone formation and healing.

Nanotopography Induced Human Bone Marrow Mesangiogenic Progenitor Cells (MPCs) to Mesenchymal Stromal Cells (MSCs) Transition

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