In the field of rehabilitation, nuanced interventions are imperative due to the intricate anatomical complexity and versatile functionality of the human hand. From fractures and tendon injuries to neurological disorders and congenital anomalies, hand orthoses, both static and active, serve as crucial adjuncts to conventional therapeutic approaches. Active hand orthoses play a pivotal role in coordinating rehabilitation efforts, offering tailored support, dynamic control, and therapeutic facilitation. This review paper explored the scientific landscape surrounding active hand orthoses, consolidating evidence-based insights into their design, functionality, and clinical applications. The paper offered an in-depth examination of various studies, showcasing pioneering designs like hinged gloves, electro-hydraulic orthoses, and those integrating virtual reality exercises. The biomechanical principles underlying the effectiveness of active hand orthoses were emphasized, highlighting their role in optimizing outcomes across different rehabilitation scenarios. The review also covered advancements in electroencephalography (EEG)-controlled orthoses and myoelectric technology, illustrating the diverse applications for hand rehabilitation. By synthesizing current knowledge, this review established a foundation for further research and advancements in the ever-evolving field of active hand orthoses.