Signet-ring cell carcinoma of the gallbladder: a case report

Abstract

Gallbladder cancers are recognised common tumours of the gastrointestinal system. Histologically, almost all of them are adenocarcinomas. Previously, only two cases of signet-ring cell carcinoma of the gallbladder have been published, and little is known about the disease. Here, we present the case of a 76-year-old man with signet cell carcinoma of the gallbladder. Despite radical surgery, followed by 5-fluorouracil infusion chemotherapy, our patient died within 3 months. Advanced information may help to improve the prognosis of this tumour.

A Case of Signet Ring Cell Carcinoma of the Gallbladder Which Was Treated by Aggressive Surgery and Intensive Adjuvant Chemotherapy

“…At present, no standard adjuvant chemotherapy regimen for gallbladder carcinoma has been established. Only a small number of reports describe adjuvant chemotherapy for SRCC of the gallbladder; however, 5-fluorouracil is associated with miserable results [5,6]. The present patient underwent sequential treatment with gemcitabine and S-1 after the operation.…”

“…Regarding the biological features, SRCC of the gallbladder has not been well characterized because of the small number of previous reports [5,6]. Gallbladder cancer is recognized to be a malignant tumor with a poor prognosis [1].…”

Extreme Rare Case of Primary Signet Ring Cell Carcinoma of Gall Bladder-Case Report

“…Signet ring cell carcinoma (SRCC) can arise from virtually any organ but most are from the stomach, breast, and colon (Bazan et al, 2011;Van Breda Vriesman et al, 2007). Regardless of the tissue origin, SRCCs frequently metastasize to peritoneal surfaces, regional lymphnodes, ovaries and lungs (Chu & Weiss, 2004;Karabulut, Yildirim, Abaci, Ilgici, & Ozyilkan, 2008;Panić, Marusić, & Mijić, 2010). Less commonly metastasis can be seen in small and large bowel, heart, kidney, ureters, diaphragm and omentum.…”

Primary signet ring cell carcinoma of gall bladder: report of an extremely rare histological type of primary gall bladder carcinoma

“…Little is known about this histological subtype of gall bladder carcinoma 1. However, some authorities believe that this variant accounts for 3% of all malignant gall bladders tumours 2.…”