Signet‐ring cell carcinoma of the gallbladder with skin metastases

Krunic, Aleksandar L.; Chen, Helen M.; Lopatka, Keith

doi:10.1111/j.1440-0960.2007.00379.x

Cited by 27 publications

(16 citation statements)

References 7 publications

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“…There are only rare reports of peritoneal 7 or pleural 9 mesothelioma involving the skin usually because of cutaneous extension or distant metastasis 10 with one report of pleural mesothelioma involving chest wall scars 9 . However, it is not uncommon for gastrointestinal malignancies to extend around surgical scars 20 . Cutaneous involvement by visceral cancers has been reported to occur in 0.7–9% of patients and is generally a late occurrence in the disease process.…”

Section: Resultsmentioning

confidence: 99%

Peritoneal mesothelioma presenting as a skin nodule

Abban

Viglione

2009

J Cutan Pathol

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Mesothelioma is a malignancy of the pleura, pericardium and peritoneum that is rarely seen in cutaneous biopsies. We present a case of a 75-year-old man with significant occupational exposure to asbestos who developed peritoneal mesothelioma that presented as a skin nodule in an old appendectomy scar. The patient presented with a complaint of increased hardness along his appendectomy scar. Physical examination revealed an anterior abdominal wall mass overlying the appendectomy scar, which was subsequently biopsied. Histologic examination of the abdominal wall mass revealed an infiltrating epithelioid and papillary neoplasm within the dermis and subcutaneous tissue. Immunohistochemical stains showed immunoreactivity for cytokeratin (CK) 7, CK 5/6, calretinin and vimentin. CK 20, monoclonal carcinoembryonic antigen, prostate-specific antigen and prostate-specific acid phosphatase were negative. The profile supported the diagnosis of mesothelioma. Cutaneous presentation of mesothelioma is rare but should be considered in the differential diagnosis of patients with significant asbestos exposure.

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Section: Resultsmentioning

confidence: 99%

Peritoneal mesothelioma presenting as a skin nodule

Abban

Viglione

2009

J Cutan Pathol

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“…Signet ring cell carcinoma of gallbladder with metastasis is extremely rare but this patient had metastasis in celiac lymph node. [11] Ultrastructurally, signet ring cell carcinoma of gallbladder reveals mucin vacuoles and the intracytoplasmic lumina, some of which are cystically dilated. In contrast, well-differentiated adenocarcinoma recapitulates the ultrastructure of normal surface epithelium although columnar cell predominates; the narrow and dark-staining pencil-like cells are also present.…”

Section: Discussionmentioning

confidence: 99%

Signet ring cell carcinoma of gallbladder with celiac lymph node metastasis in a young man

Mondal

2010

J Can Res Ther

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Gall bladder cancer is uncommon and histologically most of these are adenocarcinomas. Signet ring cell carcinoma is a rare malignancy of gallbladder. Only few cases of this histologic type have been published and detailed knowledge of this disease is not available. Here, signet ring cell carcinoma of the gallbladder in a 32-year-old man is being reported. The patient had metastasis in the celiac group of lymph nodes at the time of diagnosis. The patient underwent radical surgery, followed by chemotherapy but succumbed to the illness two months post-operatively. Newer treatment modalities and advanced information may improve the prognosis of the disease.

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“…This corresponds to what has been reported in the literature previously 3. Krunic et al 5 reported a case of signet ring cell adenocarcinoma of gall bladder with multiple metastases to the skin in the form of nodules on the skin, scalp and perianal area. Multiple metastases to bone were also seen.…”

Section: Discussionmentioning

confidence: 99%

Primary signet ring cell carcinoma of gall bladder: report of an extremely rare histological type of primary gall bladder carcinoma

Ahmad

Qureshi²

2010

Case Reports

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SummarySignet ring cell carcinoma is an extremely rare type of gall bladder carcinoma composed overwhelmingly (90%) of signet ring cells. It is necessary to exclude a gastric or colonic signet ring cell carcinoma secondarily involving the gall bladder. The primary aim of this case report is to describe the histopathological aspects of this tumour. Primary signet ring cell carcinoma of gall bladder shows dysplastic surface gall bladder epithelium with infiltration of gall bladder wall. It is also necessary to exclude benign signet ring change, which sometimes occurs in the gall bladder. However, it is always confined to the mucosa and does not infiltrate the wall. This case showed grossly diffuse thickening of the gall bladder wall and dysplastic surface epithelium of the gall bladder on histology, with sheets of signet ring cells infiltrating full thickness of the wall. It is also necessary to exclude benign signet ring cell change, which sometimes occurs in the gall bladder. However it is always confined to the mucosa and does not infiltrate the wall. BACKGROUND

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Signet‐ring cell carcinoma of the gallbladder with skin metastases

Cited by 27 publications

References 7 publications

Peritoneal mesothelioma presenting as a skin nodule

Peritoneal mesothelioma presenting as a skin nodule

Signet ring cell carcinoma of gallbladder with celiac lymph node metastasis in a young man

Primary signet ring cell carcinoma of gall bladder: report of an extremely rare histological type of primary gall bladder carcinoma

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