Signet Ring Cell Carcinoma of the Stomach: A Clinicopathological Comparison with the Other Histological Types.

Yokota, Takashi; Kunii, Yasuo; Teshima, Shin‐ichi; Yamaguchi, Yasuo; Saito, Toshihiro; Kikuchi, Shu; Yamauchi, Hidemi

doi:10.1620/tjem.186.121

Cited by 87 publications

(80 citation statements)

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“…2 Stage-stratified survival curves for the non-SRC and SRC groups was found more frequently during surgery in patients with SRC-type gastric carcinoma [7,33,35]. Accordingly, Asian studies reported that the SRC histological type exhibited a lower curative resection rate and was associated with poorer overall survival [7,10,11,22].…”

Section: Discussionmentioning

confidence: 99%

“…Although the global incidence of gastric adenocarcinoma has declined in the last few years, the incidence of the signet-ring cell (SRC) type increased in the USA between 1973 and 2000 from 0.1 to 1.4 cases per 100,000 persons [2], and represents 3.5 % to 45.4 % of gastric carcinoma in recent publications [3][4][5][6][7][8][9][10][11][12]. According to the World Health Organization (WHO) classification, SRC carcinoma is an adenocarcinoma in which more than 50 % of the tumor consists of isolated or small groups of malignant cells containing intracytoplasmic mucins [13].…”

Section: Introductionmentioning

confidence: 99%

“…For advanced gastric cancer, the clinicopathological characteristics and prognosis are again controversial. While some studies have shown a better prognosis for the SRC type [12,21], other studies have reported either a poorer prognosis of this histological type [3,5,10,22] or no statistically significant difference in overall survival between patients with SRC and non-SRC tumors [4,7,8,11] throughout the whole population studied or when adjustments were made to account for tumor stage [23].…”

Section: Introductionmentioning

confidence: 99%

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Is signet-ring cell carcinoma a specific entity among gastric cancers?

et al. 2015

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Background The prognosis and chemoresistance of signet-ring cell (SRC) gastric adenocarcinoma have been reported and debated, and the utility of perioperative chemotherapy for such a tumor has been questioned. This study was performed to assess the impact of the SRC type on survival following resection of gastric adenocarcinoma, and to assess whether the prognostic factors (including perioperative chemotherapy) for non-SRC adenocarcinoma differed from those for SRC adenocarcinoma. Methods 1799 cases of adenocarcinoma that were consecutively treated from 1997 to 2010 in 19 French centers by subtotal or total gastrectomy were included in a retrospective study. A D2 lymphadenectomy was performed for antropyloric tumors, and a modified D2 for upper tumors. SRC adenocarcinoma was diagnosed based on the presence of isolated carcinoma cells containing mucin. Results A total gastrectomy was performed in 979 (54.4 %) patients. SRC adenocarcinoma was diagnosed in 899 (50 %) patients. Patients with an SRC tumor were more frequently female, younger, and malnourished, had lower ASA scores, and had larger tumors than non-SRC patients. Median survival in patients with non-SRC carcinoma was 51 months, as compared to 26 months in patients with SRC carcinoma (p \ 0.001). At multivariate analysis, SRC type remained an independent adverse prognostic factor (HR = 1.182). Factors that were prognostic in the SRC subgroup but not in the non-SRC subgroup were age [60 years, linitis, and involvement of adjacent organs. In contrast to non-SRC tumors, pre-and postoperative chemotherapy did not significantly impact on survival following resection of SRC adenocarcinoma. On behalf of the FREGAT (French Eso-GAstric Tumours) working group-FRENCH (Fédération de Recherche en Chirurgie).Electronic supplementary material The online version of this article (doi:10.1007/s10120-015-0564-2) contains supplementary material, which is available to authorized users. Conclusion In comparison to non-SRC adenocarcinoma, the SRC type has a worse prognosis, different prognostic factors, and is only poorly sensitive to perioperative chemotherapy. Non-SRC and SRC adenocarcinomas should be considered different entities in future therapeutic trials.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Is signet-ring cell carcinoma a specific entity among gastric cancers?

et al. 2015

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“…The pathological data showed that GS003 sample collected from the surrounding tissue of a signet-ring carcinoma was high grade atrophy with high grade intestinal metaplasia. Signet ring cell gastric carcinoma was characterized by poor differentiation, strong invasive tendency, and poor prognosis with invading surrounding tissue in a diffuse manner (Yokota et al, 1998;Kim et al, 2004). In many patients with signet ring cell gastric carcinoma, infiltration and metastasis happens earlier before the lesions could be seen by naked eyes through gastroscopy.…”

Section: Potential Role Of Collagens In Gastric Cancermentioning

confidence: 99%

A Potential Role of Collagens Expression in Distinguishing Between Premalignant and Malignant Lesions in Stomach

Zhao

Zhou

et al. 2009

The Anatomical Record

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Lack of clinical biomarkers for early gastric cancer without specific early symptoms leads to delayed diagnosis, which contributes to high mortality of gastric cancer. Here, we used oligonucleotide microarray to systematically examine differential gene expression among 33 samples from normal, premalignant, and malignant lesions in stomach. A focal adhesion pathway mainly composed of collagen genes was found to have a significantly different expression profile in gastric cancers compared to premalignant lesions. A subset of collagen genes efficiently separated malignant from premalignant tissues, and two representative genes COL11A1 and COL1A1 were validated in 42 tissue samples with quantitative reverse transcription-PCR and in situ hybridization. The data above suggest that focal adhesion pathway may have a role in the pathogenesis of gastric cancer, and the expression profile of collagen genes may be a potential biomarker to distinguish malignant from premalignant lesions in stomach. Anat Rec, 292:692-700, 2009. V V C 2009 Wiley-Liss, Inc.

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“…Ninety-nine percent of signet ring cell carcinomas originate in the stomach. 5 Because gastric cancer is the most likely diagnosis, EGD would be helpful to definitively locate the primary cancer. However, our patient has distant metastasis, and thus further invasive diagnostic testing is not absolutely necessary.…”

Section: Which One Of the Following Laboratory Tests Ismentioning

confidence: 99%

84-Year-Old Man With Respiratory Distress and Abdominal Distention

Pachman

Morrison

Szostek

2011

Mayo Clinic Proceedings

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A n 84-year-old man presented to his local hospital after falling from his wheelchair. He had tachypnea and abdominal distention. Chest radiography revealed a rightsided pleural effusion, and abdominal radiography showed dilated loops of bowel, suggestive of bowel obstruction. The patient was then transferred to our hospital for further work-up.The patient reported worsening of shortness of breath and abdominal distention for the past few weeks. He had a 1-year history of early satiety, nausea, and dyspepsia but had noted no weight loss. The patient was taking omeprazole for peptic ulcer disease. Recently, after positive findings on a urea breath test, metronidazole and clarithromycin were initiated for treatment of Helicobacter pylori. The patient's medical history also included type 2 diabetes, benign prostatic hyperplasia, and hypertension for which he was taking aspirin, glipizide, lisinopril, and finasteride. He was a former smoker who had quit 50 years ago.Physical examination revealed the following: temperature, 36.4° C; blood pressure, 108/58 mm Hg; regular pulse rate, 103 beats/min; respiratory rate, 26 breaths/min; and oxygen saturation of 93% while breathing 3 L of oxygen. The patient was visibly tachypneic, with diffuse expiratory wheezing and decreased breath sounds in the right base. His abdomen was distended with bulging flanks and a positive fluid wave.Important laboratory values on admission included the following (reference ranges provided parenthetically): hemoglobin, 10.4 g/dL (13.5-17.5 g/dL); white blood cells, 12.2 x 10 9 /L (3.5-10.5 x 10 9 /L); platelets, 348 x 10 9 /L (150-450 x 10 9 /L); sodium, 134 mEq/L (135-145 mEq/L); bicarbonate, 21 mEq/L (22-29 mEq/L); blood urea nitrogen, 35 mg/dL (8-24 mg/dL); creatinine, 1.5 mg/dL (0.8-1.3 mg/ dL); chloride, 103 mmol/L (100-108 mmol/L); glucose, 160 mg/dL (70-100 mg/dL); aspartate aminotransferase, 15 U/L (17-59 U/L); total bilirubin, 0.3 mg/dL (0.1-1.0 mg/dL); albumin, 2.9 g/dL (3.5-5.0 g/dL); and lactate, 0.78 mmol/L (0.6-2.3 mmol/L).Abdominal computed tomography without contrast medium showed a moderate amount of ascites, moderate right-sided pleural effusion, and a mildly nodular configuration of the liver. Thoracentesis resulted in removal of 1 L of serosanguineous fluid. Pleural fluid lactate dehydrogenase (LDH) was 724 U/L, total protein was 4.1 g/dL, glucose was 121 mg/dL, and pH was 7.7. The total nucleated cell count was 1196 U/L, with differential of neutrophils at 46%, lymphocytes at 5%, monocytes at 2%, and eosinophils at 2%. The serum LDH level was 200 U/L, and the serum protein level, 5.7 g/dL. The first step in the evaluation of the pleural fluid is to determine whether it is a transudate or exudate. On the basis of criteria from Lights et al, 1 an exudate has a pleural fluid protein to serum protein ratio greater than 0.5, pleural fluid LDH to serum LDH greater than 0.6, or pleural fluid LDH greater than two-thirds the upper limit of the laboratory's normal serum LDH level. Fulfilling any of these 3 criteria indicates an exuda...

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Signet Ring Cell Carcinoma of the Stomach: A Clinicopathological Comparison with the Other Histological Types.

Cited by 87 publications

References 13 publications

Is signet-ring cell carcinoma a specific entity among gastric cancers?

Is signet-ring cell carcinoma a specific entity among gastric cancers?

A Potential Role of Collagens Expression in Distinguishing Between Premalignant and Malignant Lesions in Stomach

84-Year-Old Man With Respiratory Distress and Abdominal Distention

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