Signet-ring cell lymphoma of T-cell origin

Grogan, Thomas M.; Richter, Lynne; Payne, Claire M.; Rangel, Catherine S.

doi:10.1097/00000478-198509000-00008

Cited by 51 publications

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“…The first examples of SRL were found to be of B-cell lineage [6][7][8][9][10]; however, six cases of SRL of T-cell type have since been reported [7][8][9][10][11][12]. Recently, Falini et al [ 13] described a case of anaplastic large-cell lymphoma, Kii-I (CD-30+), null type, with signet ring appearance.…”

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Lymphomatoid Papulosis Associated with Cutaneous T-Cell Signet Ring Lymphoma

et al. 1998

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The authors describe a new case of cutaneous T-cell lymphoma of signet ring cell type with CD-30 (Ki-t) expression. The patient was a 52-year-old woman with a 20-year history of recurrent papulonodular lesions characteristic of lymphomatoid papulosis (LP). Subsequent to developing the signet ring cell lymphoma (SRL) the patient's cutaneous lesions did not resolve as previously, and a skin biopsy showed a diffuse proliferation of atypical lymphoid cells with cytoplasmic vacuoles. SRL was first reported in 1985 by Weiss, and a literature search found only six further reports since then. Vaillant suggests that the peculiar morphology is retated to the special indolent course of this condition and that the cutaneous form should be considered a distinct entity. This is the first report of a patient with LP who subsequently developed a cutaneouis T-cell signet ring lymphoma with CD-30 antigen expression. The case could be an example of a so-called borderline lymphoma.

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Lymphomatoid Papulosis Associated with Cutaneous T-Cell Signet Ring Lymphoma

et al. 1998

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“…Aberrant membrane recycling and fusion of microvesicular bodies may account for the formation of these large vacuoles. 5 In summary, signet-ring cell lymphoma is an unusual morphologic variant of non-Hodgkin's lymphoma. Cytomorphologic features on fine needle aspiration, in addition to classic signet-ring cells, include multivacuolated cells and a background of vacuolated structures.…”

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“…4 Signet-ring cell lymphoma has been described most often as a variant of follicular lymphoma, 6 although T-cell lymphomas may also contain signetring cells. 5 Although there have been many reports of this entity in the surgical pathology literature, only two case reports describing the cytomorphology of signet-ring cell lymphoma on fine needle aspiration have appeared in the cytology literature. 10,20 We report a case of signet-ring cell lymphoma involving a submandibular lymph node initially evaluated by fine needle aspiration.…”

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“…5 It is now clear that signet-ring cell lymphoma can occur as a variant of both T-and B-cell lymphomas, the latter constituting most of the cases. Signet-ring cell lymphoma usually presents with nodal disease, 6,8,13 and there does not seem to be a predilection for any particular lymph node region.…”

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confidence: 99%

“…Signet-ring cell lymphoma usually presents with nodal disease, 6,8,13 and there does not seem to be a predilection for any particular lymph node region. Less commonly, signet-ring cell lymphoma may involve extranodal sites, such as skin, 5 thyroid gland, 1 salivary gland, 14 stomach, 16 orbit, 3 central nervous system, 11 and bone marrow. 15 The available data suggest that signet-ring cell lymphoma is not a unique clinical entity.…”

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