1989
DOI: 10.1093/ajcp/91.4.488
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Signet-Ring Squamous Cell Carcinoma

Abstract: Among carcinomas, signet-ring morphologic characteristics have been regarded as pathognomonic of adenocarcinoma. This report presents the case of a poorly differentiated cutaneous squamous cell carcinoma with a monodispersed, invasive signet-ring component. Kreyberg stains had negative results for mucin. Immunohistochemical analysis demonstrated that concentric rings in the signet-ring cells were composed of keratin. To the best of the authors' knowledge, this is the first report of signet-ring squamous cell c… Show more

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Cited by 61 publications
(49 citation statements)
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“…Breast [3] Large bowel [4] Appendix [5] Bladder, ureter, and pelvis [6] Ampulla of Vater [7] Esophagus [8] Prostate [9] Lung [10] Salivary glands [11] Sinonasal tract [12] Uterine cervix [13] Uterine corpus [14] Ovary (questionable) [15] Other neoplastic conditions Malignant lymphoma [16] Malignant melanoma [17] Basal cell carcinoma of skin [18] Squamous cell carcinoma of skin [19] Stromal tumor of ovary [20] Chondrosarcoma [21] Ependymoma [22] Malignant mesothelioma [23] Meningioma [24] Collecting duct carcinoma of kidney [25] Urothelial carcinoma of renal pelvis with collagenous spherulosis [26] Follicular adenoma and carcinoma of thyroid [27] Salivary gland adenoma [28] Pituitary adenoma [29] Carcinoid tumor of gallbladder [30] Pancreatic endocrine neoplasm [31] GIST [32] Peutz-Jeghers polyps [33] Epithelioid leiomyoma [34] Gastric schwannoma [35] Testicular seminoma [36] Nonneoplastic conditions Inflammatory/necrotizing conditions of gastrointestinal tract and gallbladder [33,[37][38][39][40][41][42][43]…”
Section: Casementioning
confidence: 99%
“…Breast [3] Large bowel [4] Appendix [5] Bladder, ureter, and pelvis [6] Ampulla of Vater [7] Esophagus [8] Prostate [9] Lung [10] Salivary glands [11] Sinonasal tract [12] Uterine cervix [13] Uterine corpus [14] Ovary (questionable) [15] Other neoplastic conditions Malignant lymphoma [16] Malignant melanoma [17] Basal cell carcinoma of skin [18] Squamous cell carcinoma of skin [19] Stromal tumor of ovary [20] Chondrosarcoma [21] Ependymoma [22] Malignant mesothelioma [23] Meningioma [24] Collecting duct carcinoma of kidney [25] Urothelial carcinoma of renal pelvis with collagenous spherulosis [26] Follicular adenoma and carcinoma of thyroid [27] Salivary gland adenoma [28] Pituitary adenoma [29] Carcinoid tumor of gallbladder [30] Pancreatic endocrine neoplasm [31] GIST [32] Peutz-Jeghers polyps [33] Epithelioid leiomyoma [34] Gastric schwannoma [35] Testicular seminoma [36] Nonneoplastic conditions Inflammatory/necrotizing conditions of gastrointestinal tract and gallbladder [33,[37][38][39][40][41][42][43]…”
Section: Casementioning
confidence: 99%
“…The signet-ring variant of cutaneous SCC is extremely uncommon. The first case was reported by Carmer and Heggeness [1], but very few cases have been reported to date [2, 3, 4, 5]. Here, we report a case of signet-cell cutaneous SCC arising on the back of a finger of an elderly male patient.…”
Section: Introductionmentioning
confidence: 83%
“…Signet-ring cutaneous SCC is thus a very rare lesion and, as far as we know, only 4 cases have been described in detail [1, 2, 3, 4] (table 1). In addition, one dermatopathologic report focused on the presence of signet-ring cells briefly described in clinical data of 6 cases [5].…”
Section: Discussionmentioning
confidence: 99%
“…Signet-ring cells or a vacuolated appearance of tumour cells have been reported in lymphoma, melanoma (Sheibani and Battifora 1988), squamous cell carcinoma (Cramer and Heggeness 1989), thyroid neoplasms (Schroeder and Boecker 1985) and meningioma (Lattes and Bigotti 1991). Regardless of the type of tumours, the signet-ring cell or vacuolated appearance is attributed to excess accumulation of some substances within the cytoplasm, produced by the tumour cells under usual conditions.…”
Section: Discussionmentioning
confidence: 99%