Signifance of placental and birth weight ratios

Sinclair, John G.

doi:10.1002/ar.1091020209

Cited by 28 publications

(9 citation statements)

References 10 publications

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“…A declining PWR with increasing gestational age reported here is similar to that described by others [21–23]. The placenta and fetus follow different growth patterns during gestation [3].…”

Section: Discussionsupporting

confidence: 90%

“…Indeed Kingdom and Kaufmann [30] report that preplacental or uteroplacental hypoxia with adaptive placental growth is a primary cause for growth restriction at term. However, the nonplacental chorion and amnion also contribute to overall placental weight, and more so for SGA infants; [23] this may also account, at least in part, for the higher PWR of infants in the SGA group. On the other hand, low PWRs are indicative of an increased efficiency of the placentas of the smaller fetuses, whereas, high PWRs are indicative of a potential failed compensation [17, 31–36].…”

Section: Discussionmentioning

confidence: 99%

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Population-Based Placental Weight Ratio Distributions

Macdonald

Koval

Natale

et al. 2014

International Journal of Pediatrics

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The placental weight ratio (PWR) is a health indicator that reflects the balance between fetal and placental growth. The PWR is defined as the placental weight divided by the birth weight, and it changes across gestation. Its ranges are not well established. We aimed to establish PWR distributions by gestational age and to investigate whether the PWR distributions vary by fetal growth adequacy, small, average, and large for gestational age (SGA, AGA, and LGA). The data came from a hospital based retrospective cohort, using all births at two London, Ontario hospitals in the past 10 years. All women who delivered a live singleton infant between 22 and 42 weeks of gestation were included (n = 41441). Nonparametric quantile regression was used to fit the curves. The results demonstrate decreasing PWR and dispersion, with increasing gestational age. A higher proportion of SGA infants have extreme PWRs than AGA and LGA, especially at lower gestational ages. On average, SGA infants had higher PWRs than AGA and LGA infants. The overall curves offer population standards for use in research studies. The curves stratified by fetal growth adequacy are the first of their kind, and they demonstrate that PWR differs for SGA and LGA infants.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Population-Based Placental Weight Ratio Distributions

Macdonald

Koval

Natale

et al. 2014

International Journal of Pediatrics

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“…A close correlation exists between fetal and placental weights in humans [Adair and T helander, 1925;Sinclair, 1948;McK eown ■This work was supported in part by Grant HD-00126-06 from the National Institute of Child Health and Human Development.…”

mentioning

confidence: 99%

Fetal Growth Retardation Produced by Experimental Placental Insufficiency in the Rhesus Monkey. I. Body Weight, Organ Size

et al. 1971

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“…Thus this ratio follows the similar trends alike found by . 4 Sinclair JG (1948) 9 had worked on placental and birth weight ratios. He studied 1517 placentae and concluded that placental weight increases with increasing birth weight, the increase being linear for all full term births, while the placental birth weight ratio was found to be decreased linearly with birth weight.…”

Section: Discussionmentioning

confidence: 99%