Significance and Location of Atrophic Gastritis and of Glandular Dysplasia in Benign and Malignant Gastric Disease

Meister, H; Holubarsch, C; Haferkamp, O; Schlag, Peter M.; Herfarth, Ch.

doi:10.1007/978-3-642-67368-9_14

Cited by 6 publications

(2 citation statements)

References 4 publications

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“…All the original biopsy specimens and any subsequent pathological material were reviewed and reclassified as (1) no dysplasia, (2) low grade dysplasia, (3) high grade dysplasia, and (4) carcinoma. Gastric cancer was classified Little is known about the natural history of epithelial dysplasia in the stomach.…”

Section: Methodsmentioning

confidence: 99%

High grade dysplasia of the gastric mucosa: a marker for gastric carcinoma.

Lansdown

Quirke

Dixon

et al. 1990

Gut

151

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The natural history of gastric epithelial dysplasia and its relation to gastric cancer are ill defined. A consecutive series of 40 patients with an initial diagnosis of gastric epithelial dysplasia based on examination of endoscopic biopsies has been reviewed to determine the clinical outcome and to evaluate a two tier histological grading system as a predictor of the risk of cancer. On review, only 20 of the 40 patients were considered to have true dysplasia: seven patients had low grade dysplasia and 13 had high grade dysplasia. Of the 13 patients with high grade dysplasia, 11 (85%) were found to have gastric cancer within 15 months. Of the 10 patients with high grade dysplasia who underwent gastrectomy, six were found to have early gastric cancer, three had cancer invading into the muscularis propria, and none had lymph node metastases.

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Section: Methodsmentioning

confidence: 99%

High grade dysplasia of the gastric mucosa: a marker for gastric carcinoma.

Lansdown

Quirke

Dixon

et al. 1990

Gut

151

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show abstract

“…1993 which is smallest in patients with duodenal ulcers [16][17][18][19][20], In order to evaluate the prevalence oflM in underlyingHP gastritis, a total of 2,692 patients were investigated. To obtain more detailed information about the relative preva lence of IM, five different groups of patients with HP gas tritis were studied: with no lesions; with duodenal, pyloric or other gastric ulcers; or with chronic erosions.…”

Section: Introductionmentioning

confidence: 99%

Antral Intestinal Metaplasia in <i>Helicobacter pylor</i><i>i</i> Gastritis

Eidt

Stolte²

1994

Digestion

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The prevalence of antral intestinal metaplasia (IM) in underlying Helicobacter pylori (HP) gastritis was studied in biopsy specimens of the antral mucosa obtained from 2,692 patients with histologically proven HP gastritis. The prevalence of IM varied in the groups investigated: 47.4% in gastric ulcers, 30.5% in pyloric ulcers, 16.8% in duodenal ulcers, 21.8% in gastritis with no lesions and 9.8% in chronic antral erosions (p < 0.001). A hypothetical model for the role of HP in the development of IM is presented: HP probably promotes mucosal regeneration. The prolonged stimulatory effect on regeneration could then, in the course of time, lead to an increasing likelihood of IM developing.

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Precursors of Early Gastric Cancer

Nagayo

1986

Histogenesis and Precursors of Human Gastric Cancer

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Significance and Location of Atrophic Gastritis and of Glandular Dysplasia in Benign and Malignant Gastric Disease

Cited by 6 publications

References 4 publications

High grade dysplasia of the gastric mucosa: a marker for gastric carcinoma.

High grade dysplasia of the gastric mucosa: a marker for gastric carcinoma.

Antral Intestinal Metaplasia in <i>Helicobacter pylor</i><i>i</i> Gastritis

Precursors of Early Gastric Cancer

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