Significance of Adenomyosis on Tumor Progression and Survival Outcome of Endometrial Cancer

Abstract

Adenomyosis appears to be associated with less aggressive tumor behavior of endometrial cancer, suggesting that it may have inhibitory effects on the progression of this disease.

Adenomyosis and Endometrial Cancer: Literature Review

“…Uterine adenomyosis was associated with deep myometrial invasion in stage I endometrioid adenocarcinoma; but this did not affect the recurrence or mortality rates. Similar finding was reported in a cohort of Stage I–IV endometrial cancer and endometrial hyperplasia patients [103]. They reported that the presence of adenomyosis was significantly associated with grade 1–2 tumours, earlier stage disease and lower likelihood of deep myometrial or cervical invasion.…”

“…It is also not clear whether cancer within adenomyosis alters the risk of deep myometrial infiltration. Some studies have suggested an increased risk [115], while others suggested a lower risk [93, 103]. Ismiil et al [100] found that patients who had cancer involvement within adenomyosis were more likely to have myometrial involvement.…”

The Effect of Adenomyosis in Myometrial Invasion and Overall Survival in Endometrial Cancer

“…One of the largest studies in the literature has been reported by Matsuo et al 23 investigating the effect of adenomyosis both in endometrioidand nonYendometrioid-type cancers. However, researchers did not include patients with nonendometrioid type of endometrial cancer in their control group.…”

Prediction of concurrent endometrial carcinoma in women with endometrial hyperplasia

“…The STROBE guidelines were consulted for reporting in a case-control study [6]. Some cases of the study population were within the context of our previous studies [7][8][9][10][11].…”