Significance of body mass index for diagnosing sarcopenia is equivalent to slow gait speed in Japanese individuals with type 2 diabetes: Cross‐sectional study using outpatient clinical data

Abstract

Aims/Introduction This study examined the association between body mass index (BMI) and the risk of sarcopenia in Japanese type 2 diabetes patients. Materials and Methods Patients with type 2 diabetes who visited an outpatient clinic comprised the study’s participants. Sarcopenia was defined using the definition of the Asian Working Group for Sarcopenia 2014. The area under the curve was examined for the presence of sarcopenia based on the receiver operating characteristic curve of BMI. Results Among 1,137 patients, 210 were diagnosed with low grip strength, 78 with slow gait speed, 444 with low muscle mass and 142 with sarcopenia. The optimal cut‐off point of BMI level for risk of sarcopenia was 24.4 kg/m2 (area under the curve 0.729, 95% confidence interval 0.688–0.770, sensitivity 0.587, specificity 0.789). Furthermore, the receiver operating characteristic curve of BMI for sarcopenia did not significantly differ (P = 0.09) from that of gait speed, an established marker of sarcopenia. In both the male and female groups, there was no difference between the receiver operating characteristic curves of BMI and gait speed for sarcopenia. (P = 0.23 and P = 0.40, respectively). Conclusions These results suggest that a BMI <24 kg/m2 among Japanese patients with type 2 diabetes could increase their risk of sarcopenia, the extent of which is equivalent to the risk for sarcopenia from slow gait speed in this study. Further prospective investigation, however, is required.

Geriatri polikliniğine başvuran tip 2 diabetes mellituslu hastalarda kas gücü ve kas kütlesinin vücut kitle indeksi ve insülin tedavisiyle ilişkisi

“…However, since sarcopenia was defined according to The Asian Working Group for Sarcopenia (AWGS) in this study, relationship between BMI and hand grip strength was not investigated, and the number of patients with only low hand grip strength was not determined. In a study conducted with type 2 DM patients in the outpatient setting, BMI with a cut-off point of 24.4 kg / m 2 predicted sarcopenia as much as walking speed (24).…”

“…Probable sarcopenia was found in 69.1% of patients with DM, while sarcopenia was found in only 1.6% of patients with DM. In the literature, the prevalence of sarcopenia varies between 12% and 18% in older patients with type 2 DM according to the AWGS and increases to 40% in DM patients aged older than 80 years (23,24,26). The prevalence of sarcopenia varies between 2% and 4% according to EWGSOP2.…”

A review on associated factors and management measures for sarcopenia in type 2 diabetes mellitus

“…BMI <24 kg/m 2 will increase the risk of sarcopenia. And the research [39] also showed that BMI may be a practical index for screening sarcopenia, and can be used as a substitute index of gait speed in the diagnosis of sarcopenia to a certain extent.…”

Association of subtle alterations in thyroid function with presarcopenia in patients with type 2 diabetes mellitus

“…Type 2 diabetes mellitus is a common cause of sarcopenia, with the risk of sarcopenia being threefold higher compared with individuals without diabetes 8 . Certain features, including age, sex, body mass index (BMI), glycemic control and a high body fat percentage are risk factors for sarcopenia in diabetes patients 9 , 10 , 11 , 12 . Nevertheless, other causes of sarcopenia in patients with type 2 diabetes mellitus are not well established.…”