Significance of catalase-peroxidase (KatG) mutations in mediating isoniazid resistance in clinical strains of Mycobacterium tuberculosis

Pharmacoinformatics-based identification of anti-bacterial catalase-peroxidase enzyme inhibitors

“…and MT-S315N [28]. In addition to the above mentioned findings, Strivastava et al, were also reported similar kind of docking interaction profiles when INH docked with MT-katG S315T protein [45].…”

“…However, mutations in katG led inability to activate INH. Mutation of katG at Ser315 is most prevalent and virulent among other several mutations have been identified so far [5,[9][10][11][12]. In our previous studies, we have designed and identified some potential anti-bacterial and anti-tubercular chemical entities as DNA gyrase B (Gyr B) inhibitors using de novo design technique, pharmacophore-based virtual screening, molecular docking and dynamics simulations studies [4,13].…”

“…Earlier, numbers of studies have adopted computational molecular modeling techniques for accelerating the anti-tubercular drug developmental process applied to various multifunctional biological target receptors or proteins of Mtb [15][16][17][18][19][20][21][22][23][24][25]. However, very few studies were employed earlier targeting specifically selected five mutation types (at codon S315 of katG) for enhancing anti-tubercular drug design and development [26][27][28]. A number of studies were performed in the detection and exploration of S315 mutation, and, their implication only [1,29,30].…”

Talaromyces marneffei Infection: Virulence, Intracellular Lifestyle and Host Defense Mechanisms

“…For example, catalase-peroxidase is a powerful reducing agent that metabolizes H 2 O 2 to water and oxygen. This enzyme is an established virulence factor in Mycobacterium tuberculosis and Aspergillus fumigatus [71,72]. The catalase-peroxidase encoding gene (CpeA) in T. marneffei is associated with the upregulated expression of CpeA transcript both in yeast phase and during macrophage infection [73].…”

Melhoramento da estabilidade física do pró-fármaco 5-Fluorocitosina >i<via>/i< cocristalização

“…[113][114][115][116] Este tipo de coinfecção tem emergido devido ao elevado uso de esteroides e antibióticos de amplo espectro. [117][118][119] O câncer de pulmão (CP) é uma das neoplasias mais letais e tornou-se um grande problema de saúde pública na população mundial. Alguns pesquisadores têm sugerido que a inflamação e a fibrose pulmonar causada pela TB podem ser responsáveis por induzir danos genéticos e, consequentemente, causar uma propensão maior para o desencadeamento de um CP (Figura 13).…”