Significance of Circulating Galectin-3 in Patients with Hepato-biliary and Pancreatic Cancer

Shimura, Tatsuo; Shibata, Masahiko; Kofunato, Yasuhide; Ishigame, Teruhide; Okada, Ryo; Kimura, Takashi; Kenjo, Akira; Marubashi, Shigeru; Ohki, Shinji; Kono, Koji; Takenoshita, Seiichi

doi:10.3919/jjsa.78.633

Cited by 1 publication

(2 citation statements)

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“…Our results showed that the plasma galectin-3 level significantly increased in hemodialysis patients at risk of PEW, although it was not an independent predictor for PEW. This finding contradicts the results of studies conducted in patients with gastrointestinal malignancy [ 25 , 26 ], and the reason for this discrepancy remains unclear. Inadequate energy and protein intake is the most important determinant of PEW in patients with ESRD [ 37 ].…”

Section: Discussioncontrasting

confidence: 87%

“…The role of galectin-3 in nutritional status assessment has not been explored until recently. For patients with biliary tract cancer, an increased plasma concentration of galectin-3 is associated with the risk of malnutrition [ 25 ]. In addition, the serum galectin-3 levels in patients newly diagnosed with colorectal carcinoma showed a significant inverse correlation with some nutritional parameters, including prealbumin, retinol-binding protein, and transferrin [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

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Relationship between Circulating Galectin-3, Systemic Inflammation, and Protein-Energy Wasting in Chronic Hemodialysis Patients

Tsai

Chen

et al. 2021

Nutrients

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Galectin-3 reportedly participates in the inflammatory process that causes insulin resistance in the target tissues. However, the role of high plasma galectin-3 levels as an indicator of protein-energy wasting (PEW) in patients undergoing maintenance hemodialysis remains unclear. This study included 240 hemodialysis patients (64.5 [55.3−74.0] years, 35.8% women) from a tertiary medical center. A baseline assessment of demographic and clinical data, biochemical parameters, and body composition was conducted. Plasma galectin-3 and other biomarkers were measured using a multiplex bead-based immunoassay. Participants were then divided into two subgroups depending on the median value of plasma galectin-3. Malnutrition was identified using the geriatric nutritional risk index (GNRI) and the criteria of the International Society of Renal Nutrition and Metabolism. Independent risk factors for elevated plasma galectin-3 and malnutrition were identified by multivariate logistic regression. The high galectin-3 group was more likely to be older, have lower lean tissue mass and GNRI scores, be diagnosed with PEW, dialyze through a tunneled catheter, and have higher circulating IL-6, TNF-α, and MCP-1 concentrations than the low galectin-3 group. After multivariate adjustment, only low mean arterial pressure, dialyzing with tunneled cuffed catheters, and elevated systemic inflammatory markers correlated with high galectin-3 levels. Plasma galectin-3 concentrations also increased significantly in hemodialysis patients with PEW. However, compared with other commonly used nutritional indicators, galectin-3 did not show superiority in predicting PEW. Although the plasma galectin-3 levels correlated with PEW severity, this correlation disappeared after adjustment for potential confounding variables (OR, 1.000; 95% CI, 0.999–1.001). In conclusion, plasma galectin-3 is a valuable biomarker for systemic inflammation but is less prominent for PEW in patients with maintenance hemodialysis. Further identification of novel biomarkers is required to detect patients at risk for malnutrition and implement appropriate interventions.

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Section: Discussioncontrasting

confidence: 87%

Section: Introductionmentioning

confidence: 99%