Significance of Cu/Zn-Superoxide Dismutase Levels in Hemodialysis Patients: A Mini Review

Nakamura, Yuya; Inagaki, Masumi; Kenmotsu, Sachiyo; Yamadera, Shiho; Ohsawa, Isao; Gotoh, Hiromichi; Goto, Yoshikazu; Sato, Naoki; Oguchi, Tamio; Tsuji, Mayumi; Kiuchi, Yuji

doi:10.4236/mri.2017.62002

Cited by 3 publications

(3 citation statements)

References 26 publications

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“…It should be noted that SOD-1 is primarily used as an antioxidant marker. However, the researchers found that because it is associated with many factors in HD patients, it could serve as a complex marker for atherosclerosis, vascular conditions, and inflammation [43]. It should be emphasized here that the research results regarding SOD are not conclusive.…”

Section: They Catalyze the Dismutation Of Omentioning

confidence: 86%

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Chronic Kidney Disease as Oxidative Stress- and Inflammatory-Mediated Cardiovascular Disease

Podkowińska¹,

2020

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Generating reactive oxygen species (ROS) is necessary for both physiology and pathology. An imbalance between endogenous oxidants and antioxidants causes oxidative stress, contributing to vascular dysfunction. The ROS-induced activation of transcription factors and proinflammatory genes increases inflammation. This phenomenon is of crucial importance in patients with chronic kidney disease (CKD), because atherosclerosis is one of the critical factors of their cardiovascular disease (CVD) and increased mortality. The effect of ROS disrupts the excretory function of each section of the nephron. It prevents the maintenance of intra-systemic homeostasis and leads to the accumulation of metabolic products. Renal regulatory mechanisms, such as tubular glomerular feedback, myogenic reflex in the supplying arteriole, and the renin–angiotensin–aldosterone system, are also affected. It makes it impossible for the kidney to compensate for water–electrolyte and acid–base disturbances, which progress further in the mechanism of positive feedback, leading to a further intensification of oxidative stress. As a result, the progression of CKD is observed, with a spectrum of complications such as malnutrition, calcium phosphate abnormalities, atherosclerosis, and anemia. This review aimed to show the role of oxidative stress and inflammation in renal impairment, with a particular emphasis on its influence on the most common disturbances that accompany CKD.

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Section: They Catalyze the Dismutation Of Omentioning

confidence: 86%

“…In opposition to SOD-1 (most of the results showed increased SOD-1 levels in HD), the lower SOD-2 content in mononuclear cells was associated with better survival in HD patients [43]. In uremic rats, Lim et al [45] discovered reduced SOD-2 in the liver, but Finsch et al found increased SOD-2 in the kidney [46].…”

Section: They Catalyze the Dismutation Of Omentioning

confidence: 99%

Chronic Kidney Disease as Oxidative Stress- and Inflammatory-Mediated Cardiovascular Disease

Podkowińska¹,

2020

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“…The results of the conducted study show that after a single session of the on-line hemodiafiltration with "high-flux" polysulfone membrane coated with vitamin E (Leocced 21H), the concentration of thiobarbituric acid reactive substances (TBARS) and the superoxide dismutase activity is significantly reduced. This can be explained by the effect of vitamin E, but also by the loss of microelement, the cofactor of the enzyme superoxide dismutase during the on-line hemodiafiltration session [25,26]. The results of the tests carried out so far show that a significant amount of microelements (selenium, zinc, copper) is lost during the on-line hemodiafiltration and hemodialysis with the "high-flux" polysulfone membrane, which results in a decrease in the activity of antioxidant enzymes, such as superoxide dismutase and glutathione peroxidase [27][28][29][30] while vitamin E is administered per os at a dose of 400-800 IU/day for 12-16 weeks for secondary prevention of cardiovascular events, and strong antioxidant effect is achieved at a dose of 1000 mg/day per os for 8 weeks (alpha tocopherol: 1.0 mg = 1.5 IU) [28][29][30].…”

Section: Discussionmentioning

confidence: 99%

The influence of vitamin E-coated dialysis membrane on oxidative stress during a single session of on-line hemodiafiltration

et al. 2021

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Background / Aim. Oxidative stress is an important risk factor for the development of cardiovascular atherosclerotic diseases in the population of patients treated with regular hemodialysis. Bioincompatibility of the dialysis membrane and increased concentration of endotoxin in the hemodialysis solution are two main factors that can stimulate oxidative stress. The paper was intended to examine the effect of a vitamin E-coated membrane on oxidative stress during a single session of on-line hemodiafiltration. Methods. Twenty-four patients undergoing hemodiafiltration with vitamin-E coated polysulfone dialysis membrane (Leoceed 21H) were examined, followed by a polysulfone dialysis membrane treatment without vitamin E (FX800). Following parameters of oxidative stress were measured: superoxide anion radical (O2 -), hydrogen peroxide (H2O2), thiobarbutyric acid reactive substances (TBARS), nitric oxide (NO2 -), catalase (CAT), superoxide dizmutase (SOD), and reduced glutathione activity (GSH). Statistical analysis included Kolmogorov-Smirnov test, Student-T test and Wilcoxon test. Results. On-line hemodiafiltration with

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Loading of doxorubicin and thymoquinone with F2 gel nanofibers improves the antitumor activity and ameliorates doxorubicin-associated nephrotoxicity

et al. 2018

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Significance of Cu/Zn-Superoxide Dismutase Levels in Hemodialysis Patients: A Mini Review

Cited by 3 publications

References 26 publications

Chronic Kidney Disease as Oxidative Stress- and Inflammatory-Mediated Cardiovascular Disease

Chronic Kidney Disease as Oxidative Stress- and Inflammatory-Mediated Cardiovascular Disease

The influence of vitamin E-coated dialysis membrane on oxidative stress during a single session of on-line hemodiafiltration

Loading of doxorubicin and thymoquinone with F2 gel nanofibers improves the antitumor activity and ameliorates doxorubicin-associated nephrotoxicity

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