Significance of DEPDC5 and MICA Variants in Hepatocellular Carcinoma risk related Hepatitis C Virus patients in Egypt

El-Daly, Mai M.; Ibrahim, Hany M.; Labib, Eman; Ghanem, Heba; El-Elaimy, Ibrahim A.; Abdel‐Hamid, Mohamed

doi:10.14744/ejmo.2019.90638

Cited by 2 publications

(13 citation statements)

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“…16 Finally, DEPDC5 (rs1012068) could be a valuable indicator in diagnosing the progression of liver disease to HCC risk related HCV patients. 6 In conclusion, this study suggested an association between DEPDC5 rs1012068 T/G gene polymorphism and liver fibrosis in chronic HCV Egyptian patients. G allele may be a risk factor for liver fibrosis among Egyptian patients.…”

Section: Discussionmentioning

confidence: 56%

“…4 Egypt shows the highest prevalence rates of HCV in the world with about 10% chronic HCV infection among people aged 15 to 59 years. 5,6 Dishevelled EGL-10 and Pleckstrin domaincontaining (DEPDC) proteins are globular protein domains of approximately 80 amino acids; all share a high degree of sequence and structure similarity with different combinations of domains generating seven members, (DEPDC1-DEPDC7) providing various functions where most of which are involved with signal transduction. 7 Dishevelled EGL-10 and Pleckstrin domain-containing 5 (DEPDC5) is a signaling molecule involved in the phosphoinositide-3 kinase/protein kinase-B/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway which has been demonstrated to block the effect of mammalian target of rapamycin (mTOR), a multi-functional protein involved in many cellular systems inflammation, cell growth and tumorigenesis.…”

Section: Introductionmentioning

confidence: 99%

“…10 DEPDC5 rs1012068 T/G gene polymorphism has been indicated to be associated with progression of liver disease. 6 This study aimed to assess the association between DEPDC5 rs1012068 T/G gene polymorphism with disease progression and related complications including liver fibrosis, cirrhosis, and HCC among Egyptian patients with chronic HCV infection.…”

Section: Introductionmentioning

confidence: 99%

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Disheveled EGL-10 and pleckstrin domain-containing 5 rs1012068 T/G gene polymorphism among Egyptian chronic HCV-infected patients: disease progression and related complications

Farhan

Abougabal

Gaber

et al. 2022

EJI

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Hepatitis C virus (HCV) infection related complications including fibrosis, cirrhosis and hepatocellular carcinoma (HCC) are influenced by host genetic factors. Identification of emerging host genetic variations is of promising value. Disheveled EGL-10 and pleckstrin domain-containing 5 (DEPDC5) rs1012068 T/G gene polymorphism has been implicated in liver disease. This study aimed to assess DEPDC5 rs1012068 T/G gene polymorphism with disease progression and related complications among Egyptian patients with chronic HCV infection. Sixty chronic HCV-infected patients and 60 apparently healthy controls were recruited in this study. Patients were classified into 20 with liver fibrosis, 20 with liver cirrhosis and 20 with HCC; all recruited from Outpatients Clinic and Tropical Medicine Inpatient Department, Faculty of Medicine, Beni-Suef University Hospital. DEPDC5 rs1012068 T/G gene polymorphism was assayed by real time-polymerase chain reaction (RT-PCR) TaqMan allelic discrimination. DEPDC5 rs1012068 GG genotype and G allele variants showed statistically significant higher frequency among patients with liver fibrosis when compared to controls (OR (95% CI) 10.500 (2.086 – 52.851), P= 0.004 and 0.388 (0.155 – 0.971), P= 0.011), respectively. DEPDC5 rs1012068G allele variant showed statistically significant higher frequency among patients with liver fibrosis when compared to HCC patients (OR (95% CI) 3.316 (1.286 – 8.550), P= 0.012) and to both HCC and cirrhosis patients (OR (95% CI) 2.579 (1.187-5.645), P= 0.016). In conclusion, our results suggest that DEPDC5 rs1012068 G allele could be considered genetic risk allele for liver fibrosis and disease progression among Egyptian patients with chronic HCV infection.

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Section: Discussionmentioning

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Disheveled EGL-10 and pleckstrin domain-containing 5 rs1012068 T/G gene polymorphism among Egyptian chronic HCV-infected patients: disease progression and related complications

Farhan

Abougabal

Gaber

et al. 2022

EJI

View full text Add to dashboard Cite

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“…No relevant case-control studies were identifed based on the alternative polymorphism IDs for rs1012068 (rs56511012, rs58339834, rs386510025) or for rs5998152 (rs61578881, rs8143107). A total of 11 studies [12][13][14][15][16][17][18][19][20][21][22] investigated rs1012068, and 3 studies [12,15,23] investigated rs5998152. Te distribution of genotypes in controls was consistent with Hardy-Weinberg equilibrium (HWE).…”

Section: Characteristics Of Primary Studiesmentioning

confidence: 99%

“…In addition to these associations between DEPDC5 and various diseases, polymorphisms in the DEPDC5 gene have been linked to the risk of HCC [12][13][14][15][16][17][18][19][20][21][22][23]. A genome-wide association study frst demonstrated that the DEPDC5 variant rs1012068 could increase HCC risk in individuals with chronic HCV infection [12], and this relationship was replicated in several studies [15,18,20]. On the other hand, several studies did not fnd such a relationship [9,14,18].…”

Section: Introductionmentioning

confidence: 99%

Correlation of DEPDC5 rs1012068 and rs5998152 Polymorphisms with Risk of Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis

Zhu

Zhong

Zou

et al. 2023

Journal of Oncology

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Background. Emerging evidence has shown that two common genetic polymorphisms within the pleckstrin domain-containing protein 5 (DEPDC5), rs1012068 and rs5998152, may be associated with the risk of hepatocellular carcinoma (HCC), especially in those individuals chronically infected with the hepatitis C virus (HCV) or the hepatitis B virus (HBV). However, these findings have not been consistently replicated in the literature due to limited sample sizes or different etiologies of HCC. Thus, the present systematic review and meta-analysis were performed to resolve this inconsistency. Methods. The databases PubMed, Embase, Web of Science, the China National Knowledge Infrastructure, and Scopus were searched up to December 12, 2022. Data from relevant studies were pooled, and odds ratios and 95% confidence intervals were calculated. Results. A total of 11 case-control studies encompassing 2,609 cases and 8,171 controls on rs1012068 and three encompassing 411 cases and 1,448 controls on rs5998152 were included. Results indicated that the DEPDC5 rs1012068 polymorphism did not significantly increase HCC risk in the total population (allelic model (OR = 1.32, 95% CI = 1.04–1.67, P = 0.02); the recessive model (OR = 1.42, 95% CI = 0.96–2.10, P = 0.08); the dominant model (OR = 1.43, 95% CI = 1.09–1.87, P = 0.01); the homozygous model (OR = 1.61, 95% CI = 1.01–2.57, P = 0.05); the heterozygous model (OR = 1.39, 95% CI = 1.09–1.79, P = 0.009)). Subgroup analyses based on ethnicity and etiology revealed that the rs1012068 polymorphism, under all five genetic models, was associated with increased HCC risk in Asians or in individuals with chronic HBV infection but not in individuals with chronic HCV infection. A significant association was also observed between rs5998152 and HCV-related HCC risk in Asians chronically infected with HCV under allelic, dominant, and heterozygous models. Conclusion. Our study suggests that the DEPDC5 rs1012068 polymorphism increases HCC risk, especially in Asians with chronic HBV infection, while the rs5998152 polymorphism increases HCC risk in Asians with chronic HCV infection.

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Significance of DEPDC5 and MICA Variants in Hepatocellular Carcinoma risk related Hepatitis C Virus patients in Egypt

Cited by 2 publications

References 0 publications

Disheveled EGL-10 and pleckstrin domain-containing 5 rs1012068 T/G gene polymorphism among Egyptian chronic HCV-infected patients: disease progression and related complications

Disheveled EGL-10 and pleckstrin domain-containing 5 rs1012068 T/G gene polymorphism among Egyptian chronic HCV-infected patients: disease progression and related complications

Correlation of DEPDC5 rs1012068 and rs5998152 Polymorphisms with Risk of Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis

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