Significance of E-cadherin, β-catenin, and vimentin expression as postoperative prognosis indicators in cervical squamous cell carcinoma

Cheng, Yanan; Ying, Zhe; Jiang, Wenjing; Yang, Xia; Zhu, Jing; Feng, Dingqing; Wei, Ying; Li, Min; Fengqiu, Yao; Hu, Weiping; Xiao, Weihua; Ling, Bin

doi:10.1016/j.humpath.2011.08.025

Cited by 44 publications

(40 citation statements)

References 25 publications

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“…Our cDNA microarray data confirmed down-regulation of the CTNNB1 and TUSC2 interaction partners, which have been proposed to be tumour suppressors [28,29], and up-regulation of CUL4A and TFDP1 , which have been suggested as targets of the 13q34 amplification in breast cancer [30]. Moreover, low CTNNB1 protein level has been associated with poor outcome of cervical cancer patients [29,31], further supporting the view that an aggressive tumour phenotype was reflected in the network.…”

Section: Discussionsupporting

confidence: 78%

Identification of eight candidate target genes of the recurrent 3p12–p14 loss in cervical cancer by integrative genomic profiling

Lando

Wilting

Snipstad

et al. 2013

The Journal of Pathology

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The pathogenetic role, including its target genes, of the recurrent 3p12-p14 loss in cervical cancer has remained unclear. To determine the onset of the event during carcinogenesis, we used microarray techniques and found that the loss was the most frequent 3p event, occurring in 61% of 92 invasive carcinomas, in only 2% of 43 high-grade intraepithelial lesions (CIN2/3), and in 33% of 6 CIN3 lesions adjacent to invasive carcinomas, suggesting a role in acquisition of invasiveness or early during the invasive phase. We performed an integrative DNA copy number and expression analysis of 77 invasive carcinomas, where all genes within the recurrent region were included. We selected eight genes, THOC7, PSMD6, SLC25A26, TMF1, RYBP, SHQ1, EBLN2, and GBE1, which were highly down-regulated in cases with loss, as confirmed at the protein level for RYBP and TMF1 by immunohistochemistry. The eight genes were subjected to network analysis based on the expression profiles, revealing interaction partners of proteins encoded by the genes that were coordinately regulated in tumours with loss. Several partners were shared among the eight genes, indicating crosstalk in their signalling. Gene ontology analysis showed enrichment of biological processes such as apoptosis, proliferation, and stress response in the network and suggested a relationship between down-regulation of the eight genes and activation of tumourigenic pathways. Survival analysis showed prognostic impact of the eight-gene signature that was confirmed in a validation cohort of 74 patients and was independent of clinical parameters. These results support the role of the eight candidate genes as targets of the 3p12-p14 loss in cervical cancer and suggest that the strong selection advantage of the loss during carcinogenesis might be caused by a synergetic effect of several tumourigenic processes controlled by these targets.

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Section: Discussionsupporting

confidence: 78%

Identification of eight candidate target genes of the recurrent 3p12–p14 loss in cervical cancer by integrative genomic profiling

Lando

Wilting

Snipstad

et al. 2013

The Journal of Pathology

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“…E-cadherin and vimentin were found to be prognostic factors for both DFS and OS for lung cancer [47, 49] and oral squamous cancer [50]. E-cadherin has also been suggested as a positive indicator for OS for cervical squamous carcinoma [51] and CRC [52]. In our Kaplan-Meier survival analysis, E-cadherin and vimentin expression was demonstrated to be significant for both DFS and OS.…”

Section: Discussionmentioning

confidence: 66%

Epithelial-Mesenchymal Transition Phenotype, Metformin, and Survival for Colorectal Cancer Patients with Diabetes Mellitus II

Wang

2017

Gastroenterology Research and Practice

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Objectives We aimed to explore the association between metformin treatment and epithelial-mesenchymal transition (EMT) phenotype and further appraise the prognostic values of metformin and EMT markers E-cadherin and vimentin for colorectal cancer (CRC) in clinical practice. Methods We collected specimens and evaluated clinicopathological parameters of 102 stage I to III CRC patients with prediagnosed type 2 diabetes mellitus (DM II). Expression of E-cadherin and vimentin in tumors was detected by immunohistochemistry (IHC), and statistical analysis was performed using SPSS 19.0. Results In correlation tests, we found a lower tumor cell EMT degree (more E-cadherin (P = 0.014) and less vimentin (P = 0.011) expression in patients who used metformin, and the expression of E-cadherin and vimentin was associated with serum CA19-9 (P = 0.048, P = 0.009), tumor invasive depth (T) (P < 0.001, P = 0.045), and lymph invasion (N) (P = 0.013, P = 0.001). In Cox multivariate regression analysis, E-cadherin was identified as a prognostic factor for disease-free survival (DFS) (P = 0.038) and metformin use (P = 0.015P = 0.044) and lymph invasion (P = 0.016P = 0.023) were considered as the prognostic factors for both DFS and overall survival (OS). Conclusion Our study suggested that metformin may impede the EMT process and improve survival for stage I–III CRC patients with DM II.

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“…Cheng et al demonstrates that decreased expression of E-cadherin and β-catenin were correlated with the degree of tumor differentiation, metastasis and recurrence in patients with cervical cancer, while vimentin overexpression was inversely correlated with the above mentioned parameters. The authors concluded that the association between E-cadherin decrease and vimentin increase can be a useful indicator for evaluation of the recurrence rate and survival [15].…”

Section: Discussionmentioning

confidence: 99%

The biologic behavior of squamous cervical carcinoma after neoadjuvant therapy (NAT) according to immunohistochemical expression of E-cadherin and CD44v6

Gavrilescu¹,

Bălan²,

Scripcariu³

et al. 2016

Arch Clin Cases

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The efficiency of neoadjuvant therapy in cervical carcinoma has been well demonstrated, although the cellular mechanisms of different response to this treatment have not been thoroughly investigated. The present study consists of 24 patients with cervical cancer, including 12 patients in stages IB-IIIB with first-line surgical treatment and 12 patients in stages IIB-IIIB, with neoadjuvant therapy followed by radical hysterectomy. The aim of our study was to assess the correlations between the alterations in E-cadherin and CD44v6 immunoexpression in cervical carcinoma, as a tool of evaluation the response to neoadjuvant therapy and its prognostic significance. The intensity of CD44v6 immunoexpression was higher in more aggressive tumors and E-cadherin immunoexpression was approximately constant among the cases with neoadjuvant therapy. Our results demonstrate that the evaluation of CD44v6 immunoexpression in cervical carcinomas is useful for the assessment of tumor response to neoadjuvant therapy and of tumor aggressiveness. The high level of Ecadherin immunoexpression in tumors with neoadjuvant therapy reflects its involvement in the prevention of HPV oncoproteins action, with benefits on the outcome. A larger group of patients and a panel of antibodies, including CD4 and COX2, could provide a better characterization of the tumor response to neoadjuvant therapy, with a positive prognosis impact.

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Significance of E-cadherin, β-catenin, and vimentin expression as postoperative prognosis indicators in cervical squamous cell carcinoma

Cited by 44 publications

References 25 publications

Identification of eight candidate target genes of the recurrent 3p12–p14 loss in cervical cancer by integrative genomic profiling

Identification of eight candidate target genes of the recurrent 3p12–p14 loss in cervical cancer by integrative genomic profiling

Epithelial-Mesenchymal Transition Phenotype, Metformin, and Survival for Colorectal Cancer Patients with Diabetes Mellitus II

The biologic behavior of squamous cervical carcinoma after neoadjuvant therapy (NAT) according to immunohistochemical expression of E-cadherin and CD44v6

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