Significance of Earlier Carotid Atherosclerosis for Stroke Subtypes

Nagai, Yoji; Kitagawa, Kazuo; Sakaguchi, Manabu; Shimizu, Yoshiomi; Hashimoto, Hiroyuki; Yamagami, Hiroshi; Narita, Masako; Ohtsuki, Toshiho; Hori, Masatsugu; Matsumoto, Masayasu

doi:10.1161/01.str.32.8.1780

Cited by 86 publications

(52 citation statements)

References 37 publications

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“…Carotid atherosclerosis is considered to be representative for systemic atherosclerosis [1,2]. Due to the carotid accessibility, ultrasonography (US) examination is a safe technique, being recommended by the American Society of Echocardiography (ASE) to determine the vascular age and the risk for cardiovascular events [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Carotid intima-media thickness and hemodynamic parameters: reproducibility of manual measurements with Doppler ultrasound

et al. 2015

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Aims: To evaluate the carotid ultrasound intra-and interobserver agreements in a common clinical scenario when making manual measurements of the intima-media thickness (IMT) and peak systolic (PSV) and end diastolic (EDV) velocities in the common (CCA) and the internal carotid (ICA) arteries. Material and methods: Three different experienced operators performed two time-point carotid ultrasounds in 21 patients with cardiovascular risk factors. Each operator measured freehand the CCA IMT three consecutive times in each examination. The CCA and ICA hemodynamic parameters were acquired just once. . Intraobserver agreements were fair-moderate for PSVs and good-excellent for EDVs. Interobserver agreements were good-excellent for both PSVs and EDVs. Overall, 95% confidence intervals were narrower for the left IMTmean and CCA velocities. Conclusions: Intra and interobserver agreements in carotid ultrasound are variable. In order to improve carotid IMT agreements, IMTmean is preferable over IMTmax.

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Section: Introductionmentioning

confidence: 99%

Carotid intima-media thickness and hemodynamic parameters: reproducibility of manual measurements with Doppler ultrasound

et al. 2015

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“…Nevertheless, associations between carotid atherosclerosis and the specific stroke subtypes have not been established. [9] Stroke and computer tomography exam:…”

Section: General Viewmentioning

confidence: 99%

“…The linkage is supported by an association between carotid and systemic atherosclerosis. [9] Carotid ultrasound can provide the following information:…”

Section: Agementioning

confidence: 99%

Correlations Between Atherosclerosis and Stroke –Can We Predict It?

Ionescu¹,

Muflic²,

Carciumaru³

et al. 2016

Eur. j. soc. sci. educ. res.

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Although, atherosclerosis is a risk factor for stroke, there are many questions about this relationship. Stroke remains the major cause of disability and death, and atherosclerosis is responsible for 15-20 % of strokes. Moreover, atherosclerosis is not likely to play a direct role in cardioembolic infarction, intracerebral and subarachnoid hemorrhage. This study aimed to elucidate how the presence of carotid atherosclerosis influenced the occurance of stroke and also how it interacted with other risk factors for stroke. Is it possible to make predicttions about it?

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“…It is related to atheromatous plaque on stability in narrow places (Jander et al, 2001). CAAD is believed to be the primary cause of ischemic stroke (Nagai et al, 2001). Therefore, the basic study of CAAD is especially important for people's health.…”

Section: Introductionmentioning

confidence: 99%

Association of paraoxonase polymorphisms with carotid artery atherosclerosis in essential hypertension patients

Han¹,

Xu²,

Xue³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. We investigated the relationships between paraoxonase genetic polymorphisms and essential hypertension in carotid artery atherosclerotic patients. The study included 353 Han participants and 240 Uighur participants from Xinjiang; they were further divided into two groups: essential hypertension with carotid artery atherosclerosis (CAAD group) and essential hypertension without carotid artery atherosclerosis (control group). Genotypes were detected by PCR, followed by restriction analyses with specific endonucleases. In Han people, the M allele frequency was significantly higher in the CAAD group than in the control group. The CC/CS genotype and C allele frequencies were significantly higher in the CAAD group than in the control group. Logistic regression analysis demonstrated that PON1 55M allele [odds ratio (OR) = 1.889] and PON2 311C allele (OR = 1.692) are independent risk factors for CAAD. Combined genotype analysis showed that PON1 55M and PON2 311C alleles are independent risk 5175 ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 12 (4): 5174-5185 (2013) Atherosclerosis in essential hypertension patients factors for CAAD (OR = 1.428). In the Uighur population, the CC/ CS genotype and C allele frequencies were significantly higher in the CAAD group than in the control group. Logistic regression analysis demonstrated that the PON2 311C allele is an independent risk factor for CAAD. We conclude that the PON1 55M and PON2 311C alleles are independent risk factors for CAAD in essential hypertension patients from the Xinjiang Han population. We also conclude that the PON2 311C allele is a risk factor for CAAD in essential hypertension patients from the Xinjiang Uighur population.

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Significance of Earlier Carotid Atherosclerosis for Stroke Subtypes

Cited by 86 publications

References 37 publications

Carotid intima-media thickness and hemodynamic parameters: reproducibility of manual measurements with Doppler ultrasound

Carotid intima-media thickness and hemodynamic parameters: reproducibility of manual measurements with Doppler ultrasound

Correlations Between Atherosclerosis and Stroke –Can We Predict It?

Association of paraoxonase polymorphisms with carotid artery atherosclerosis in essential hypertension patients

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