The heat transfer coefficient (HTC) and frictional pressure drop (FPD) of R513A in flow boiling conditions experimentally investigated in the present article. The study employed micro-fin tubes (MFT1 and MFT2) and smooth tubes (ST1 and ST2) as testing tubes under various operational parameters. The test sections featured standardized tube lengths (1000 mm) and outer diameter (9.52 mm) across all tubes, with variations in mass flux (50–300 kg·m−2·s−1), vapor quality (0.02–0.96), saturation temperature (12°C, 17°C, and 22 °C) and heat flux (6, 18, and 30 kW·m−2). Research focused on evaluating influence of micro-fin enhancement on flow boiling characteristics, specifically comparing HTC and FPD between micro-fin and smooth tubes. Results indicate significant improvement on HTC within micro-fin tubes compared to smooth tubes, accompanied by reasonable increase in FPD. Additionally, the study validated experimental data against established correlations and conducted sensitivity analysis to understand influence of key parameters on HTC and FPD. Overall, findings contribute valuable insights for optimizing heat exchanger design and thermal system efficiency in flow boiling applications.