Significance of Her-2/neu protein over expression in Indian breast cancer patients

Kumar, Vineet; Tewari, Mallika; Singh, Usha; Shukla, H. S.

doi:10.1007/s12262-007-0002-8

Cited by 22 publications

(32 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Further, Saleh and Abdeen [23] reported increased positivity of ER with age while PR positivity did not have any significant variation. A previous Western study also showed similar results, though other studies showed no correlation between age and Her2/neu expression [14,24]. Tumor size in our study was 2 cm and 54.9 % of cases have T2 tumors.…”

Section: Discussionsupporting

confidence: 85%

“…This ER and PR expression is lower and Her2/neu expression is higher when compared with the Western studies which have shown 73 % ER positivity and 58 % PR positivity and 17-30 % Her2/neu positivity [12]. The frequency of Her2/ neu positivity varies among Indian studies such as 43.2 % in Vaidyanathan et al [13] study, 40.2 % in Munjal et al [11] study and 46.3 % in Kumar et al [14] study. This variation in Her2/neu positivity may be due to method of detection of Her2/neu in those studies.…”

Section: Discussionmentioning

confidence: 95%

See 1 more Smart Citation

Study of Hormone Receptors and Epidermal Growth Factor Expression in Invasive Breast Cancers in a Cohort of Western India

Dodiya¹,

Patel²,

Patel³

et al. 2013

Ind J Clin Biochem

View full text Add to dashboard Cite

The objective of study was to evaluate and correlate the pathological characteristics of breast cancer patients with estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (Her2/neu) detected by immunohistochemistry and/or fluorescent in situ hybridization method. We have conducted 2 year study of 204 cases of breast cancer at HCG-Medisurge Hospitals, Ahmedabad from 2009 to 2011. Significant correlation was found in ER and PR expression whereas no correlation was found in hormonal receptors and Her2/neu expression. ER and PR positivity increased with advancing age in breast carcinoma patients while not affecting Her2/neu expression. The expression of hormone receptors were higher in infiltrating lobular carcinoma and infiltrating duct carcinoma subtypes of breast carcinoma as compared to other subtypes such medullary and in situ carcinoma. High-grade carcinoma patients were predominantly ER/PR negative and Her2/neu positive as compared to lower grade breast carcinoma whereas high-stage carcinoma patients were ER/PR positive and Her2/neu positive as compared to lower stage breast carcinoma.

show abstract

Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 95%

Study of Hormone Receptors and Epidermal Growth Factor Expression in Invasive Breast Cancers in a Cohort of Western India

Dodiya¹,

Patel²,

Patel³

et al. 2013

Ind J Clin Biochem

View full text Add to dashboard Cite

show abstract

“…Kumar et al from India also found similar results 13 . They reported mean tumor size 3.4 cm and 85.8% of their cases were having tumor size more than 2 cm.…”

Section: Molecular Subtypes Immunohistochemical Characterizationsupporting

confidence: 56%

Profile of Molecular Subtypes of Breast Cancer Among Bangladeshi Women : Audit of Initial Experience

Rahman

Karim

2018

Chatt Maa Shi Hosp Med Coll J

View full text Add to dashboard Cite

Background : Receptor status and molecular subtyping of breast cancers are crucial for patient management.We present here our initial experience on the status of different molecular subtypes and clinicopathological characteristics of invasive breast carcinomas in Bangladeshi population especially in Chittagong zone. Methods : A total of 59 histopathologically confirmed cases of invasive ductal carcinoma were selected for this study. Fifteen out of 59 cases were reported as HER2 equivalent and could not be categorized into any subtype because of the lack of availability of fluorescence in situ hybridization. The remaining 44 cases were distributed into different molecular subtypes and then the clinicopathological characteristics were compared for each molecular subtype. Results : Age ranges from 24-70 years with a mean age of 43.95 years. Most of the patients were in 41-50 years age group. Among the 44 cases, most common subtype was HER2/neu amplification 13 cases (29.55%). Luminal A, luminal B and basal like subtypes were 11 (25%) 10 (22.73%) and 10 (22.73%) respectively. The mean tumor size was 3.46 cm and the highest mean tumor size was in basal like subtype (4.01cm). Twenty five out of 59 cases (42.37%) showed axillary lymph node metastasis. Lowest axillary lymph node metastasis was found in luminal A subtype (3/11=27.27%). Conclusion : HER2/neu amplification subtype was found to be more common in this region. Luminal A subtype was found to be more favorable in comparison to the other subtypes in terms of axillary lymph node metastasis.

show abstract

“…Vaidyanathan et al from the same region reported it to be 43.2% positivity in BC cases (Vaidyanathan et al, 2010). This finding was further supported by a group from Indore city Central India which showed 40.2% positivity and Varanasi city from Northern India exhibited 46.3% positivity (Kumar et al, 2007;Munjal et al, 2009). Reports from Asian , 2006;Naeem et al, 2008;Kamil et al, 2010).…”

Section: Discussionmentioning

confidence: 64%

HER-2/neu Status: A Neglected Marker of Prognostication and Management of Breast Cancer Patients in India

Zubeda¹,

Kaipa²,

Shaik³

et al. 2013

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Background: Categorizing breast tumors based on the ER, PR and HER/Neu 2 receptor status is necessary in order to predict outcome and assist in management of breast cancer. Herfe we assessed this question in South Indian patients. Materials and Methods: A total of 619 formalin fixed paraffin embedded breast tumor tissues were collected from pathology archives after receipt of ethical clearance. With the help of primary and secondary conjugated antibodies, expression status of ER, PR and HER2/neu was determined. All the experimental data were assessed for correlations with histopathological features of tumors and clinical presentation of the subjects. Results: In the present study, the ages ranged from 20-87 years with a mean of 50.0±12.q years, and majority of the tumors (84%) were of infiltrating duct cell carcinoma type. Assessment of ER, PR and Her-2/neu expression showed that 46% were triple negative. Interestingly, an inverse relation between ER, PR and HER-2/neu was apparent in 41.2% (p<0.0001) of the tumors, of which 24.5% (p<0.0001) were ER and PR co-negative but HER-2 positive. Conclusions: ER and PR positive tumors are less common (i.e<30%) compared to HER-2/neu positive tumors (i.e>50%) in Indian breast cancer patients, underlining the need for effective diagnostic screening and specific therapeutic managements in order to improve the survival rate of patients in low resource countries such as India.

show abstract

Significance of Her-2/neu protein over expression in Indian breast cancer patients

Cited by 22 publications

References 21 publications

Study of Hormone Receptors and Epidermal Growth Factor Expression in Invasive Breast Cancers in a Cohort of Western India

Study of Hormone Receptors and Epidermal Growth Factor Expression in Invasive Breast Cancers in a Cohort of Western India

Profile of Molecular Subtypes of Breast Cancer Among Bangladeshi Women : Audit of Initial Experience

HER-2/neu Status: A Neglected Marker of Prognostication and Management of Breast Cancer Patients in India

Contact Info

Product

Resources

About