Significance of Infectious Agents in Colorectal Cancer Development

Abstract

Colorectal cancer (CRC) is a major burden to healthcare systems worldwide accounting for approximately one million of new cancer cases worldwide. Even though, CRC mortality has decreased over the last 20 years, it remains the third most common cause of cancer-related mortality, accounting for approximately 600,000 deaths in 2008 worldwide. A multitude of risk factors have been linked to CRC, including hereditary factors, environmental factors and inflammatory syndromes affecting the gastrointestinal tract. Recently, various pathogens were added to the growing list of risk factors for a number of common epithelial cancers, but despite the multitude of correlative studies, only suggestions remain about the possible relationship between selected viruses and bacteria of interest and the CRC risk. United States military service members are exposed to various risk factors impacting the incidence of cancer development. These exposures are often different from that of many sectors of the civilian population. Thereby, cancer risk identification, screening and early detection are imperative for both the military health care beneficiaries and the population as a whole. In this review, we will focus on several pathogens and their potential roles in development of CRC, highlighting the clinical trials evaluating this correlation and provide our personal opinion about the importance of risk reduction, health promotion and disease prevention for military health care beneficiaries.

No Detection of Streptococcus gallolyticus and Helicobacter pylori in Colorectal Cancer Tissue Samples in Shiraz, Iran

“…Colorectal cancer is one of the most common types of cancer worldwide (1). Sporadic occurrence and heterogenetic nature of colorectal cancer, including many factors, may be involved in colorectal cancer (7).…”

“…Worldwide, colorectal cancer is one of the main problems for healthcare systems, accounting for approximately one million of new cases yearly (1). Epidemiological studies have shown that colorectal cancer is the fourth most common cancer in Iran (2,3).…”

“…The development of malignancy is associated with several hereditary and environmental factors (2,5,6). Environmental factors, including infectious agents, have been estimated to be attributed for 20% of all cancers (1,6).…”

MicroRNA-185 suppresses growth and invasion of colon cancer cells through inhibition of the hypoxia-inducible factor-2α pathway in vitro and in vivo

“…Although CRC mortality has decreased over the last 20 years, it remains the third most common cause of cancer-associated mortality, accounting for ~600,000 fatalities in 2008 worldwide (1). Therefore, identification of tumor biomarkers for screening and early detection is imperative for patients with colon cancer.…”

“…Colorectal cancer (CRC) is a major burden to healthcare systems worldwide, accounting for approximately one million novel cancer cases (1). Although CRC mortality has decreased over the last 20 years, it remains the third most common cause of cancer-associated mortality, accounting for ~600,000 fatalities in 2008 worldwide (1).…”