Significance of measurement of high-sensitivity C-reactive protein in acute pancreatitis

Abstract

Measurement of hs-CRP levels is a simple and inexpensive method. The hs-CRP levels were found to significantly increase in the early phase of severe acute pancreatitis, suggesting that hs-CRP could possibly serve as an early indicator of the progression of acute pancreatitis into a serious state.

Correlation between ranson score and red cell distribution width (RDW) in acute pancreatitis

“…[16] C-reactive protein (CRP) is broadly recognized as indicator of severity 48 hours after disease onset with value greater than 150 mg/dL and other causes of inflammation, such as cholangitis and pneumonia, ruled out. [17][18][19][20] Sensitivity and positive predictive value of serum CRP level in patients with severe AP have been reported to be 83% to 90% and 75% to 86%, respectively, with remarkable increase from onset of AP through first 72 hours. [19] However, CRP level on admission is poor predictor of severity of the disease as result of increased hepatic synthesis due to inflammation-induced cytokine release, and has initial accuracy similar to that of APACHE II score.…”

“…[17][18][19][20] Sensitivity and positive predictive value of serum CRP level in patients with severe AP have been reported to be 83% to 90% and 75% to 86%, respectively, with remarkable increase from onset of AP through first 72 hours. [19] However, CRP level on admission is poor predictor of severity of the disease as result of increased hepatic synthesis due to inflammation-induced cytokine release, and has initial accuracy similar to that of APACHE II score. [7] Interleukin 6 (IL-6) is major mediator of CRP and is released primarily by macrophages.…”

“…Though 1 study reported sensitivity of 67% and specificity of 100% with IL-10 for prediction of severity on first day of AP, [24] other studies have stated less reliable results compared with IL-6 and IL-8. [19] Tumor necrosis factor alpha (TNF-α), which is produced primarily by macrophages, is a cytokine that stimulates acute phase reaction. Many clinicians have investigated its role in predicting severity of AP.…”

Targeted inhibition of gene expression of pancreatitis‐associated proteins exacerbates the severity of acute pancreatitis in rats

“…23 The extent of pancreas edema was quantitated by the ratio of pancreas wet weight over subjects' total body weights.13 For morphologic analysis, 5-µm-thick paraffin sections of pancreas samples were stained with H&E. Ten randomly chosen microscopic fields were examined for each tissue sample, and inflammation as well as necrosis were scored as follows: none = 0; mild = 1; moderate = 2; and severe = 3.24…”

Is Prior Aspirin Use Associated with Reduced Severity in Patients with Acute Pancreatitis?

“…CRP is an inflammatory marker that has been described as a marker of AP severity [25][26][27]. Various studies have used different cut-off points to differentiate mild and severe AP [26,28].…”