Significance of Oxidants and Inflammatory Mediators in Blood of Patients Undergoing Cardiac Surgery

Elahi, Maqsood M.; Yii, Michael; Matata, Bashir M.

doi:10.1053/j.jvca.2007.12.022

Cited by 24 publications

(20 citation statements)

References 106 publications

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“…Aortic manipulation, which used in conventional CABG, was a potential source of atheroemboli that could cause post-procedural cerebral infarction, especially for seriously aortic calcification patients. Comparing to OPCAB, ONCAB needs prolonged postoperative stay and occurred more postoperative complication such as renal impairment, coagulopathy, and even increased mortality (16)(17)(18). And this is consistent with our study.…”

Section: Discussionmentioning

confidence: 99%

Outcomes of off-pump versus on-pump coronary artery bypass graft surgery in patients with severely dilated left ventricle

Gong

et al. 2016

Ann. Transl. Med.

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Background: Currently, off-pump coronary artery bypass (OPCAB) grafting has been the standard procedure for surgical revascularization in patients with coronary artery disease (CAD). This study aimed to examine the safety and applicability of OPCAB compared with on-pump coronary artery bypass (ONCAB) in patients with severely dilated left ventricle. Results: A total of 24 patients underwent ONCAB, and 26 underwent OPCAB. Both groups had similar preoperative profiles. Two cases from each group died during in-hospital time. In comparison to OPCAB, there was longer operation and post-surgery intubation time and more renal dysfunction in ONCAB group (P<0.05). Oneyear survival between OPCAB and ONCAB were not significantly different (87.5% vs. 92.3%, P>0.05).Conclusions: OPCAB is a safe and feasible alternative for CAD patients with giant left ventricle, offering a significant advantage over ONCAB with regards to renal function, operation duration and length of ventilation.

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Section: Discussionmentioning

confidence: 99%

Outcomes of off-pump versus on-pump coronary artery bypass graft surgery in patients with severely dilated left ventricle

Gong

et al. 2016

Ann. Transl. Med.

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“…[21-22] Pro-inflammatory cytokines interleukin-2 (IL-2), Interleukin-6 (IL-6), and tumour necrosis factor-α (TNF-α) are found in higher concentrations in the circulating blood of ischaemic heart disease and CHF patients compared with normal subjects [23]. Studies have demonstrated that TNF-α can depress myocardial contractility and induce cardiomyopathy on its own [24].…”

Section: Chf and Underlying Mechanisms Of Propagationmentioning

confidence: 99%

Current Concepts Underlying Benefits of Exercise Training in Congestive Heart Failure Patients

Elahi

Mahmood²,

Ahmad³

et al. 2010

CCR

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The pathophysiology of several conditions including heart failure is partly attributable to a failure of the cell energy metabolism. Studies have shown that exercise training (ET) improves quality of life (QOL) and is beneficial in terms of reduction of symptoms, mortality and duration of hospitalization. Increasingly, ET is now achieving acceptance as complimentary therapy in addition to routine clinical practice in patients with chronic heart failure (CHF). However, the mechanisms underlying the beneficial effects of ET are far less understood and need further evaluation. Evidence suggests that while CHF induces generalized metabolic energy depletion, ET largely enhances the overall function of the heart muscle. Hence, research efforts are now aiming to uncover why ET is beneficial as a complimentary treatment of CHF in the context of improving endothelial function and coronary perfusion, decreasing peripheral resistance, induction of cardiac and skeletal muscle cells remodeling, increasing oxygen uptake, substrate oxidation, and resistance to fatigue. Here we discuss the current evidence that suggest that there are beneficial effects of ET on cardiac and skeletal muscle cells oxidative metabolism and intracellular energy transfer in patients with CHF.

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“…11,17 It has been shown that NO production from inducible nitric oxide Mesenteric endothelial dysfunction in a cardiopulmonary bypass rat model: The effect of diabetes synthase (iNOS) and superoxide anion (O 2 − ) levels are already increased in patients with diabetes under basal conditions. [19][20][21] Similarly, CPB is associated with enhanced production of oxidative stress 22 and NO 11 from iNOS and endothelium-constitutive NOS (eNOS). 1,[23][24][25] The cumulative effects of diabetes and CPB on oxidative stress and NO metabolism, as well as their impact on mesenteric endothelial function, could partially explain the morbidity and mortality associated with diabetes in cardiac surgery.…”

Section: Introductionmentioning

confidence: 99%

Mesenteric endothelial dysfunction in a cardiopulmonary bypass rat model: The effect of diabetes

Guillou

Tamion

Jouet

et al. 2012

Diabetes and Vascular Disease Research

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Background: Diabetes is a risk factor for perioperative complications after cardiac surgery. We studied its effects on mesenteric endothelial function in a cardiopulmonary bypass (CPB) model. Methods: Forty Wistar rats were divided into four groups: sham (D-CPB-), cardiopulmonary bypass (D-CPB+), diabetic (D+CPB-) and diabetic that have undergone CPB (D+CPB+). Two samples of mesenteric artery were used for nitric oxide synthase (NOS) Western blot analysis, and two others for assessing contractile response and endothelium relaxations. Nitrite products and tumour necrosis factor-alpha (TNF-α) were assessed as markers of inflammatory response. Results: We observed an enhanced contractile response to the α-adrenergic agonist associated with impairment of mesenteric vasorelaxation in D+CPB+ rats. Western immunoblot analysis of D+CPB+ highlighted an additive effect of hyper-expression of inducible NOS. A significantly increased inflammatory response was observed after CPB in diabetic animals. Conclusions: This work confirms the potential deleterious impact of diabetes on the mesenteric endothelium during CPB in cardiac surgery.

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Significance of Oxidants and Inflammatory Mediators in Blood of Patients Undergoing Cardiac Surgery

Cited by 24 publications

References 106 publications

Outcomes of off-pump versus on-pump coronary artery bypass graft surgery in patients with severely dilated left ventricle

Outcomes of off-pump versus on-pump coronary artery bypass graft surgery in patients with severely dilated left ventricle

Current Concepts Underlying Benefits of Exercise Training in Congestive Heart Failure Patients

Mesenteric endothelial dysfunction in a cardiopulmonary bypass rat model: The effect of diabetes

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