Significance of Pre‐existent Conditions in Basal Cell Carcinoma on the Lower Extremities

Abstract

Pre-existent cutaneous changes, thus, are thought to be a possible etiologic factor in the pathogenesis of BCC on the lower extremities.

Pre‐Existing Cutaneous Changes in Basal Cell Carcinomas of the Lower Extremities

“…Noodleman and Pollack (21) reported 7.3% of BeCs had a previous history of such predisposing factors; Kopf, 12.7% (9); and Yamada, 9.5% (22) over the whole body. Predisposing factors or preexisting cutaneous changes in the BCCs of the lower extremities were observed in 25% of cases by Nogita (11). We could not confirm these observations.…”

Basal cell carcinoma of the lower extremities

“…Nogita et al . 10 reported that 25% of the lower extremity BCCs in Japan arose in sites of pre‐existent cutaneous changes such as radiodermatitis and seborrheic keratoses. This was not seen in our patient population.…”

Recurrent Basal Cell Carcinoma of the Lower Limb with Tibial Invasion

“…Nogita and colleagues reported that 25% of lower limb BCCs in Japan occurred in sites with preexisting skin changes, such as radiodermatitis. 12 Our patient had no previous lesions.…”

“…Several studies have reported incidence rates ranging from 1.5 to 13.5%. 1,2,11,12 These findings suggest that BCCs commonly occur in areas exposed to sunlight as a result of ultraviolet light damage, and the legs are usually less exposed to sunlight than the head and neck. A higher incidence has been reported in women.…”

“…This variant may be more common in skin areas that are intermittently exposed to sunlight. 12 However, our patient had an infiltrative BCC. Some researchers state that cumulative exposure to ultraviolet light (as typically occurs in the head and neck) results more commonly in nodular BCCs.…”