Significance of prediabetes as a nosological entity

Štěpánek, Ladislav; Horáková, D; Nakládalová, Marie; Cibičková, Ľubica; Karásek, David; Zadrazil, J

doi:10.5507/bp.2018.057

Cited by 4 publications

(4 citation statements)

References 74 publications

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“…PreDM, a prominent risk factor of T2DM, is characterized as an asymptomatic condition, as individuals rarely present with physical symptoms, such as polydipsia, polyphagia, and fatigue, as seen in T2DM [ 5 , 24 ]. However, the literature documents that there are some microvascular and macrovascular changes that begin in the prediabetic state that may contribute to the long-term complications of T2DM if prediabetes progresses to T2DM [ 9 , 24 , 25 ]. A large proportion of the global population is predisposed to prediabetes.…”

Section: Prediabetesmentioning

confidence: 99%

Prediabetes-Associated Changes in Skeletal Muscle Function and Their Possible Links with Diabetes: A Literature Review

Dlamini,

Khathi

2023

IJMS

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The skeletal muscle plays a critical role in regulating systemic blood glucose homeostasis. Impaired skeletal muscle glucose homeostasis associated with type 2 diabetes mellitus (T2DM) has been observed to significantly affect the whole-body glucose homeostasis, thereby resulting in other diabetic complications. T2DM does not only affect skeletal muscle glucose homeostasis, but it also affects skeletal muscle structure and functional capacity. Given that T2DM is a global health burden, there is an urgent need to develop therapeutic medical therapies that will aid in the management of T2DM. Prediabetes (PreDM) is a prominent risk factor of T2DM that usually goes unnoticed in many individuals as it is an asymptomatic condition. Hence, research on PreDM is essential because establishing diabetic biomarkers during the prediabetic state would aid in preventing the development of T2DM, as PreDM is a reversible condition if it is detected in the early stages. The literature predominantly documents the changes in skeletal muscle during T2DM, but the changes in skeletal muscle during prediabetes are not well elucidated. In this review, we seek to review the existing literature on PreDM- and T2DM-associated changes in skeletal muscle function.

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Section: Prediabetesmentioning

confidence: 99%

Prediabetes-Associated Changes in Skeletal Muscle Function and Their Possible Links with Diabetes: A Literature Review

Dlamini,

Khathi

2023

IJMS

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“…Complete epidemiological data concerning prediabetes are not available as there are no uniform diagnostic criteria that would be used by all scientific societies ( Table 1 ), and there are no representative data from most of the world’s countries [ 2 , 4 , 5 ].…”

Section: Definition and Prevalencementioning

confidence: 99%

Chronic Microvascular Complications in Prediabetic States—An Overview

Baranowska-Jurkun

Matuszewski

Bandurska-Stankiewicz

2020

JCM

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A prediabetic state is a major risk factor for the development of diabetes, and, because of an identical pathophysiological background of both conditions, their prevalence increases parallelly and equally fast. Long-term hyperglycemia is the main cause inducing chronic complications of diabetes, yet the range of glucose levels at which they start has not been yet unequivocally determined. The current data show that chronic microvascular complications of diabetes can be observed in patients with abnormal glucose metabolism in whom glycaemia is higher than optimal but below diagnostic criteria for diabetes. Prediabetes is a heterogenous nosological unit in which particular types are differently characterized and show different correlations with particular kinds of complications. Analysis of the latest research results shows the need to continue studies in a larger population and can imply the need to verify the currently employed criteria of diagnosing diabetes and chronic complications of diabetes in people with prediabetes.

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“…Prediabetes is an intermediate metabolic condition between normal and diabetes mellitus with blood glucose level more than the normal and lower than that of diabetes mellitus (Bansal, 2015). Most people are not aware of prediabetes, because they are asymptomatic (Stepanek, 2018). Type 2 diabetes mellitus and prediabetes are emergence risk factors for development of cardiovascular disorders, as these are associated with accelerated atherosclerosis (Arnold, 2020;Fan, 2017).…”

Section: Introductionmentioning

confidence: 99%

Lipoprotein (a) Level Among Patients with Type 2 Diabetes Mellitus and Prediabetes in Comparison with Healthy Controls

Abdullah

Salih

2023

SJUOZ

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Objective: Diabetes mellitus type 2 is a chronic endocrine condition defined as high blood glucose concentration and produced by either insulin resistance or relative lack of insulin, Prediabetes is a metabolic disorder defined by high blood glucose levels that are below the diagnostic threshold for diabetes mellitus. This study aimed to measure lipoprotein (a) levels in individuals with type 2 diabetes mellitus and prediabetic individuals. Methods: A cross-sectional research was performed at Diabetes Unit at Azadi Teaching Hospital, Kurdistan region, Iraq. The study group consist of 235 participants, 85 type 2 diabetic patients, 60 prediabetic individuals and 90 individuals as control group. Results: Mean levels of Lipoprotein (a) were higher in patients with type 2 diabetes mellitus (60.43±13.19 mg/dl) and prediabetic individuals (42.53±11.65 mg/dl) in comparison with healthy control (27.3±11.16 mg/dl). Moreover, there was higher prevalent rate of abnormal high lipoprotein (a) among type 2 diabetic patients (69 ,81.1%) and prediabetic individuals (10, 16.7%). Conclusion: High mean level of lipoprotein (a) and high prevalence rate of abnormal high lipoprotein (a) were observed in type 2 diabetic patients and prediabetic individuals.

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Significance of prediabetes as a nosological entity

Cited by 4 publications

References 74 publications

Prediabetes-Associated Changes in Skeletal Muscle Function and Their Possible Links with Diabetes: A Literature Review

Prediabetes-Associated Changes in Skeletal Muscle Function and Their Possible Links with Diabetes: A Literature Review

Chronic Microvascular Complications in Prediabetic States—An Overview

Lipoprotein (a) Level Among Patients with Type 2 Diabetes Mellitus and Prediabetes in Comparison with Healthy Controls

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